A population model evaluating the consequences of the evolution of double-resistance and tradeoffs on the benefits of two-drug antibiotic treatments

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Campbell, Ellsworth M ^a,b   Chao, Lin ^a  

^a University of California San Diego   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT;

ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DOSE CONCURRENCY; DRUG CYCLING; DRUG MIXTURE; DRUG USE; DRUG UTILIZATION; HUMAN; NONHUMAN; PHARMACOLOGICAL PARAMETERS; POPULATION MODEL; TRADEOFF;

ALGORITHMS; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; BIOLOGICAL EVOLUTION; COMPUTER SIMULATION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, BIOLOGICAL; MUTATION;

EID: 84900309851     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086971     Document Type: Article

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