Antibiotic cycling or rotation: A systematic review of the evidence of efficacy

Journal of Antimicrobial Chemotherapy

Volumn 55, Issue 1, 2005, Pages 6-9

  Brown, Erwin M ^a   Nathwani, Dilip ^b  

^a FRENCHAY HOSPITAL   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Antibiotic resistance; Intensive care units; Interventions to optimize antibiotic prescribing

Indexed keywords

AMIKACIN; CEFTAZIDIME; GENTAMICIN; PIPERACILLIN PLUS TAZOBACTAM;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ANTIMICROBIAL ACTIVITY; BACTERIAL COLONIZATION; COMPARATIVE STUDY; DRUG EFFICACY; DRUG MIXTURE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ENTEROCOCCUS; EVIDENCE BASED MEDICINE; INFECTION CONTROL; INFORMATION RETRIEVAL; INTENSIVE CARE UNIT; INTERMETHOD COMPARISON; MATHEMATICAL MODEL; MEDLINE; MICROBIAL COLONIZATION; MULTIDRUG RESISTANCE; NONHUMAN; PRESCRIPTION; PUBLICATION; REDUCTION; REVIEW; SYSTEMATIC REVIEW;

ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; CLINICAL TRIALS; DRUG ADMINISTRATION SCHEDULE; DRUG RESISTANCE, BACTERIAL; HUMANS; INTENSIVE CARE UNITS; RANDOMIZED CONTROLLED TRIALS; TREATMENT OUTCOME;

EID: 13244249601     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkh482     Document Type: Review

References (16)

1. Bergstrom, C. T., Lipsitch, M. & McGowan, J. E., Jr (2004). Nomenclature and methods for studies of antimicrobial switching (cycling). [Online.] http://Octavia.zoology.washington.edu/disease/AAC.pdf (1 July 2004, date last accessed).
2. Dominguez, E. A., Smith, T. L., Reed, E. et al. (2000). A pilot study of antibiotic cycling in a hematology-oncology unit. Infection Control and Hospital Epidemiology 21, Suppl., S4-S8.
3. Puzniak, L. A., Mayfield, J., Leet, T. et al. (2001). Acquisition of vancomycin-resistant enterococci during scheduled antimicrobial rotation in an intensive care unit. Clinical Infectious Diseases 33, 151-7.
4. Raymond, D. P., Pelletier, S. J., Crabtree, T. D. et al. (2001). Impact of a rotating empiric antibiotic schedule on infectious mortality in an intensive care unit. Critical Care Medicine 29 1101-8.
5. Saravolatz, L. D., Arking, L., Pohlod, D. et al. (1984). An outbreak of gentamicin-resistant Klebsiella pneumoniae: analysis of control measures. Infection Control 5, 79-84.
6. Gruson, D., Hilbert, G., Vargas, F. et al. (2000). Rotation and restricted use of antibiotics in a medical intensive care unit. American Journal of Respiratory and Critical Care Medicine 162, 837-43.
7. Moss, W. J., Beers, M. C., Johnson, E. et al. (2002). Pilot study of antibiotic cycling in a pediatric intensive care unit. Critical Care Medicine 30, 1877-82.
8. Gruson, D., Hilbert, G., Vargas, F. et al. (2003). Strategy of antibiotic rotation: long-term effect on incidence and susceptibilities of Gram-negative bacilli responsible for ventilator-associated pneumonia. Critical Care Medicine 31, 1908-14.
9. Gerding, D. N. & Larson, T. A. (1985). Aminoglycoside resistance in gram-negative bacilli during increased amikacin use: comparison of experience in fourteen United States hospitals with experience in the Minneapolis Veterans Administration Medical Center. American Journal of Medicine 79, Suppl. 1A, 1 -7.
10. Young, E. J., Sewell, C. M., Koza, M. A. et al. (1985). Antibiotic resistance patterns during aminoglycoside restriction. American Journal of Medical Sciences 290, 223-7.
11. Bradley, S. J., Wilson, A. L., Allen, M. C. et al. (1999). The control of hyperendemic glycopeptide-resistant Enterococcus spp. on a haematology unit by changing antibiotic usage. Journal of Antimicrobial Chemotherapy 43, 261-6.
12. Toltzis, P., Dul, M., Hoyen, C. et al. (2002). The effect of antibiotic rotation on colonization with antibiotic-resistant bacilli in a neonatal intensive care unit. Pediatrics 110, 707-11.
13. Fridkin, S. K. (2003). Routine cycling of antimicrobial agents as an infection-control measure. Clinical Infectious Diseases 36, 1438-44.
14. John, J. F., Jr & Rice, L. B. (2000). The microbial genetics of antibiotic cycling. Infection Control and Hospital Epidemiology 21, Suppl., S22-S31.
15. Bonhoeffer, S., Lipsitch, M. & Levin, B. R. (1997). Evaluating treatment protocols to prevent antibiotic resistance. Proceedings of the National Academy of Sciences USA 94, 12106-11.
16. Lo, M., Bergstrom, C. T. & Lipsitch, M. (2002). Comparison of antimicrobial cycling and mixing using stochastic mathematical models. In Abstracts of the Forty-second Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, 2002. Abstract 1345, p. 326. American Society for Microbiology, Washington, DC, USA.