Interleukin 28B rs12979860 single-nucleotide polymorphism predicts spontaneous clearance of hepatitis C virus in children

Journal of Pediatric Gastroenterology and Nutrition

Volumn 58, Issue 5, 2014, Pages 666-668

  Indolfi, Giuseppe ^a   Mangone, Giusi ^a   Calvo, Pier Luigi ^b   Bartolini, Elisa ^a   Regoli, Marta ^c   Serranti, Daniele ^c   Calitri, Carmelina ^b   Tovo, Pier Angelo ^b   De Martino, Maurizio ^c   Azzari, Chiara ^c   Resti, Massimo ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

chromosome 19; chronic hepatitis C; interferon l; natural history; treatment

Indexed keywords

INTERLEUKIN 28B; IL28B PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE;

ADOLESCENT; ARTICLE; COHORT ANALYSIS; FEMALE; GENE; GENETIC ASSOCIATION; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; VIRAL CLEARANCE; CHILD; GENETICS; HEPACIVIRUS; IMMUNOLOGY; INFANT; ITALY; PRESCHOOL CHILD; REMISSION; VIREMIA; VIROLOGY; YOUNG ADULT;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; GENOTYPE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INFANT; INTERLEUKINS; ITALY; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; REMISSION, SPONTANEOUS; VIREMIA; YOUNG ADULT;

EID: 84900307043     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0000000000000275     Document Type: Article

References (23)

1. Immunization, vaccines and biologicals: hepatitis. www.who.int/immu nization/topics/hepatitis. Accessed April 3, 2014.
2. Bortolotti F, Verucchi G, Cammà C, et al. Long-term course of chronic hepatitis C in children: from viral clearance to end-stage liver disease. Gastroenterology 2008;134:1900-7.
3. European Paediatric Hepatitis C Virus Network. Three broad modalities in the natural history of vertically acquired hepatitis C virus infection. Clin Infect Dis 2005;41:45-51.
4. Resti M, Jara P, Hierro L, et al. Clinical features and progression of perinatally acquired hepatitis C virus infection. J Med Virol 2003;70: 373-7.
5. Thomas DL, Thio CL, Martin MP, et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 2009;461:798-801.
6. Tillmann HL, Thompson AJ, Patel K, et al. A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice. Gastroenterology 2010;139:1586-92.
7. Ruiz-Extremera A, Muñoz-Gámez JA, Salmerón-Ruiz MA, et al. Genetic variation in interleukin 28B with respect to vertical transmission of hepatitis C virus and spontaneous clearance in HCV-infected children. Hepatology 2011;53:1830-8.
8. Indolfi G, Sambrotta M, Moriondo M, et al. Genetic variation in interleukin-28B locus is associated with spontaneous clearance of HCV in children with non-1 viral genotype infection. Hepatology 2011;54:1490-1.
9. Resti M, Bortolotti F, Vajro P, et al. Committee of Hepatology of the Italian Society of Pediatric Gastroenterology and Hepatology. Guidelines for the screening and follow-up of infants born to anti-HCV positive mothers. Dig Liver Dis 2003;35:453-7.
10. Indolfi G, Azzari C, Resti M. Perinatal transmission of hepatitis C virus. J Pediatr 2013;163:1549-52.
11. Cooper S, Erickson AL, Adams EJ, et al. Analysis of a successful immune response against hepatitis C virus. Immunity 1999;10:439-49.
12. Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nature Rev Immunol 2005;5:215-29.
13. Lange CM, Zeuzem S. IL28B single nucleotide polymorphisms in the treatment of hepatitis C. J Hepatol 2011;55:692-701.
14. Langhans B, Kupfer B, Braunschweiger I, et al. Interferon-lambda serum levels in hepatitis C. J Hepatol 2011;54:859-65.
15. Honda M, Sakai A, Yamashita T, et al. Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C. Gastroenterology 2010;139:499-509.
16. Urban TJ, Thompson AJ, Bradrick SS, et al. IL28B genotype isassociated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C. Hepatology 2010;52:1888-96.
17. Suppiah V, Moldovan M, Ahlenstiel G, et al. IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet 2009;41:1100-4.
18. Ge D, Fellay J, Thompson AJ, et al. Genetic variation in IL28B predicts hepatitisCtreatment-induced viral clearance. Nature 2009;461:399-401.
19. Rauch A, Kutalik Z, Descombes P, et al. Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterology 2010;138:1338-45.
20. Domagalski K, Pawłowska M, Tretyn A, et al. Impact of IL-28B polymorphisms on pegylated interferon plus ribavirin treatment response in children and adolescents infected with HCV genotypes 1 and 4. Eur J Clin Microbiol Infect Dis 2013;32:745-54.
21. Komatsu H, Inui A, Tsunoda T, et al. Association between an IL-28B genetic polymorphism and the efficacy of the response-guided pegy-lated interferon therapy in children with chronic hepatic C infection. Hepatol Res 2013;43:327-38.
22. Shaker OG, Nassar YH, Nour ZA, et al. Single-nucleotide polymorphisms of IL-10 and IL-28b as predictors of the response of IFN therapy in HCV genotype 4-infected children. J Pediatr Gastroenterol Nutr 2013; 57:155-60.
23. Indolfi G, Nesi A, Resti M. Treatment of chronic hepatitis B and C in children. Future Virol 2012;7:955-72.