Vascular calcification in patients with type 2 diabetes: The involvement of matrix Gla protein

Cardiovascular Diabetology

Volumn 13, Issue 1, 2014, Pages

  Liabeuf, Sophie ^a,b   Olivier, Bourron ^c   Vemeer, Cees ^d   Theuwissen, Elke ^d   Magdeleyns, Elke ^d   Aubert, Carole E ^c   Brazier, Michel ^a   Mentaverri, Romuald ^a   Hartemann, Agnes ^c   Massy, Ziad A ^a,e  

^a UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^b AMIENS UNIVERSITY HOSPITAL   (France)

^c ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^d MAASTRICHT UNIVERSITY   (Netherlands)

^e LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

Author keywords

Matrix gla protein; Peripheral calcification; Type 2 diabetes

Indexed keywords

ANTIVITAMIN K; OSTEOCALCIN;

ADULT; ARTERY CALCIFICATION; ARTICLE; BLOOD VESSEL CALCIFICATION; CARBOXYLATION; CARDIOVASCULAR DISEASE; COHORT ANALYSIS; COMPUTED TOMOGRAPHY SCANNER; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; NON INSULIN DEPENDENT DIABETES MELLITUS; PERIPHERAL VASCULAR SYSTEM; PROTEIN DEPHOSPHORYLATION;

AGED; BIOLOGICAL MARKERS; CALCIUM-BINDING PROTEINS; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; EXTRACELLULAR MATRIX PROTEINS; FEMALE; HUMANS; MALE; MIDDLE AGED; VASCULAR CALCIFICATION;

EID: 84900033702     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/1475-2840-13-85     Document Type: Article

References (32)

1. Guzman RJ, Brinkley DM, Schumacher PM, Donahue RM, Beavers H, Qin X. Tibial artery calcification as a marker of amputation risk in patients with peripheral arterial disease. J Am Coll Cardiol 2008, 51(20):1967-1974. 10.1016/j.jacc.2007.12.058, 2836514, 18482666.
2. Kronmal RA, McClelland RL, Detrano R, Shea S, Lima JA, Cushman M, Bild DE, Burke GL. Risk factors for the progression of coronary artery calcification in asymptomatic subjects: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 2007, 115(21):2722-2730. 10.1161/CIRCULATIONAHA.106.674143, 17502571.
3. Raggi P, Cooil B, Ratti C, Callister TQ, Budoff M. Progression of coronary artery calcium and occurrence of myocardial infarction in patients with and without diabetes mellitus. Hypertension 2005, 46(1):238-243. 10.1161/01.HYP.0000164575.16609.02, 15851627.
4. Rossi A, Targher G, Zoppini G, Cicoira M, Bonapace S, Negri C, Stoico V, Faggiano P, Vassanelli C, Bonora E. Aortic and mitral annular calcifications are predictive of all-cause and cardiovascular mortality in patients with type 2 diabetes. Diabetes Care 2012, 35(8):1781-1786. 10.2337/dc12-0134, 3402245, 22699285.
5. Aoki A, Murata M, Asano T, Ikoma A, Sasaki M, Saito T, Otani T, Jinbo S, Ikeda N, Kawakami M, Ishikawa SE. Association of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes. Cardiovasc Diabetol 2013, 12:11. 10.1186/1475-2840-12-11, 3558393, 23302066.
6. Sheng L, Cao W, Cha B, Chen Z, Wang F, Liu J. Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes. Cardiovasc Diabetol 2013, 12:22. 10.1186/1475-2840-12-22, 3558414, 23342952.
7. Schurgers LJ, Spronk HM, Skepper JN, Hackeng TM, Shanahan CM, Vermeer C, Weissberg PL, Proudfoot D. Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification. J Thromb Haemost 2007, 5(12):2503-2511. 10.1111/j.1538-7836.2007.02758.x, 17848178.
8. Schurgers LJ, Uitto J, Reutelingsperger CP. Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization. Trends Mol Med 2013, 19(4):217-226. 10.1016/j.molmed.2012.12.008, 23375872.
9. Cranenburg EC, Koos R, Schurgers LJ, Magdeleyns EJ, Schoonbrood TH, Landewe RB, Brandenburg VM, Bekers O, Vermeer C. Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species. Thromb Haemost 2010, 104(4):811-822. 10.1160/TH09-11-0786, 20694284.
10. Schurgers LJ, Barreto DV, Barreto FC, Liabeuf S, Renard C, Magdeleyns EJ, Vermeer C, Choukroun G, Massy ZA. The circulating inactive form of matrix gla protein is a surrogate marker for vascular calcification in chronic kidney disease: a preliminary report. Clin J Am Soc Nephrol 2010, 5(4):568-575. 10.2215/CJN.07081009, 2849687, 20133489.
11. Dalmeijer GW, van der Schouw YT, Magdeleyns EJ, Vermeer C, Verschuren WM, Boer JM, Beulens JW. Matrix Gla Protein Species and Risk of Cardiovascular Events in Type 2 Diabetic Patients. Diabetes Care 2013, 36(11):3766-3771. 10.2337/dc13-0065, 23877986.
12. Parker BD, Schurgers LJ, Vermeer C, Schiller NB, Whooley MA, Ix JH. The association of uncarboxylated matrix Gla protein with mitral annular calcification differs by diabetes status: The Heart and Soul study. Atherosclerosis 2010, 210(1):320-325. 10.1016/j.atherosclerosis.2009.11.023, 2862076, 20015492.
13. Thomsen SB, Rathcke CN, Zerahn B, Vestergaard H. Increased levels of the calcification marker matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease. Cardiovasc Diabetol 2010, 9:86. 10.1186/1475-2840-9-86, 3016330, 21143859.
14. Silaghi CN, Fodor D, Craciun AM. Circulating matrix Gla protein: a potential tool to identify minor carotid stenosis with calcification in a risk population. Clin Chem Lab Med 2013, 51(5):1115-1123.
15. Doyon M, Mathieu P, Moreau P. Decreased expression of gamma-carboxylase in diabetes-associated arterial stiffness: impact on matrix Gla protein. Cardiovasc Res 2013, 97(2):331-338. 10.1093/cvr/cvs325, 23118128.
16. Schurgers LJ, Teunissen KJ, Knapen MH, Kwaijtaal M, van Diest R, Appels A, Reutelingsperger CP, Cleutjens JP, Vermeer C. Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification. Arterioscler Thromb Vasc Biol 2005, 25(8):1629-1633. 10.1161/01.ATV.0000173313.46222.43, 15961706.
17. Schurgers LJ, Spronk HM, Soute BA, Schiffers PM, DeMey JG, Vermeer C. Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats. Blood 2007, 109(7):2823-2831.
18. Shroff RC, McNair R, Figg N, Skepper JN, Schurgers L, Gupta A, Hiorns M, Donald AE, Deanfield J, Rees L, Shanahan CM. Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. Circulation 2008, 118(17):1748-1757. 10.1161/CIRCULATIONAHA.108.783738, 18838561.
19. Cranenburg EC, Vermeer C, Koos R, Boumans ML, Hackeng TM, Bouwman FG, Kwaijtaal M, Brandenburg VM, Ketteler M, Schurgers LJ. The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification. J Vasc Res 2008, 45(5):427-436. 10.1159/000124863, 18401181.
20. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 1990, 15(4):827-832. 10.1016/0735-1097(90)90282-T, 2407762.
21. Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 1997, 386(6620):78-81. 10.1038/386078a0, 9052783.
22. Jia G, Stormont RM, Gangahar DM, Agrawal DK. Role of matrix Gla protein in angiotensin II-induced exacerbation of vascular calcification. Am J Physiol Heart Circ Physiol 2012, 303(5):H523-H532. 10.1152/ajpheart.00826.2011, 3468471, 22796540.
23. Wajih N, Borras T, Xue W, Hutson SM, Wallin R. Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells: evidence for an uptake mechanism for serum fetuin. J Biol Chem 2004, 279(41):43052-43060. 10.1074/jbc.M407180200, 15280384.
24. Boxma PY, van den Berg E, Geleijnse JM, Laverman GD, Schurgers LJ, Vermeer C, Kema IP, Muskiet FA, Navis G, Bakker SJ, De Borst MH. Vitamin k intake and plasma desphospho-uncarboxylated matrix Gla-protein levels in kidney transplant recipients. PLoS One 2013, 7(10):e47991.
25. Flammer AJ, Gossl M, Li J, Matsuo Y, Reriani M, Loeffler D, Simari RD, Lerman LO, Khosla S, Lerman A. Patients with an HbA1c in the prediabetic and diabetic range have higher numbers of circulating cells with osteogenic and endothelial progenitor cell markers. J Clin Endocrinol Metab 2012, 97(12):4761-4768. 10.1210/jc.2012-2642, 3513527, 23015657.
26. Fadini GP, Albiero M, Menegazzo L, Boscaro E, Vigili De Kreutzenberg S, Agostini C, Cabrelle A, Binotto G, Rattazzi M, Bertacco E, Bertorelle R, Biasini L, Mion M, Plebani M, Ceolotto G, Angelini A, Castellani C, Menegolo M, Grego F, Dimmeler S, Seeger F, Zeiher A, Tiengo A, Avogaro A. Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetes. Circ Res 2011, 108(9):1112-1121. 10.1161/CIRCRESAHA.110.234088, 21393578.
27. Johnson RC, Leopold JA, Loscalzo J. Vascular calcification: pathobiological mechanisms and clinical implications. Circ Res 2006, 99(10):1044-1059. 10.1161/01.RES.0000249379.55535.21, 17095733.
28. Price PA, Faus SA, Williamson MK. Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves. Arterioscler Thromb Vasc Biol 1998, 18(9):1400-1407. 10.1161/01.ATV.18.9.1400, 9743228.
29. Chatrou ML, Winckers K, Hackeng TM, Reutelingsperger CP, Schurgers LJ. Vascular calcification: the price to pay for anticoagulation therapy with vitamin K-antagonists. Blood Rev 2012, 26(4):155-166. 10.1016/j.blre.2012.03.002, 22520397.
30. Holden RM, Morton AR, Garland JS, Pavlov A, Day AG, Booth SL. Vitamins K and D status in stages 3-5 chronic kidney disease. Clin J Am Soc Nephrol 2010, 5(4):590-597. 10.2215/CJN.06420909, 2849681, 20167683.
31. Krueger T, Westenfeld R, Ketteler M, Schurgers LJ, Floege J. Vitamin K deficiency in CKD patients: a modifiable risk factor for vascular calcification?. Kidney Int 2009, 76(1):18-22. 10.1038/ki.2009.126, 19387474.
32. Westenfeld R, Krueger T, Schlieper G, Cranenburg EC, Magdeleyns EJ, Heidenreich S, Holzmann S, Vermeer C, Jahnen-Dechent W, Ketteler M, Floege J, Schurgers LJ. Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial. Am J Kidney Dis 2012, 59(2):186-195. 10.1053/j.ajkd.2011.10.041, 22169620.