Aberrant expression of CD13 identifies a subgroup of standard-risk adult acute lymphoblastic leukemia with inferior survival

Clinical Lymphoma, Myeloma and Leukemia

Volumn 14, Issue 3, 2014, Pages 239-244

  Dalal, Bakul I ^a   Al Mugairi, Areej ^a   Pi, Steven ^a   Lee, Soo Yeon ^a   Khare, Nikisha S ^a   Pal, Jason ^a   Bryant, Adam ^b   Vakil, Alok P ^a   Lau, Sally ^b   Abou Mourad, Yasser R ^b  

^a VANCOUVER GENERAL HOSPITAL   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Flow cytometry; Immunophenotyping; Prognosis; Risk stratification

Indexed keywords

ASPARAGINASE; CD20 ANTIGEN; CD33 ANTIGEN; CD34 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; FOLINIC ACID; MERCAPTOPURINE; METHOTREXATE; MICROSOMAL AMINOPEPTIDASE; PREDNISONE; TENIPOSIDE; TIOGUANINE; VINCRISTINE; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER PATIENT; CANCER SURVIVAL; FEMALE; FLOW CYTOMETRY; HIGH RISK PATIENT; HUMAN; IMMUNOPHENOTYPING; LEUKEMIA RELAPSE; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; RECURRENCE FREE SURVIVAL; GENE EXPRESSION; GENETICS; METABOLISM; MIDDLE AGED; MORTALITY; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; RETROSPECTIVE STUDY; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD13; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BIOLOGICAL MARKERS; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOPHENOTYPING; MALE; MIDDLE AGED; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84900018259     PISSN: 21522650     EISSN: 21522669     Source Type: Journal    
DOI: 10.1016/j.clml.2013.10.003     Document Type: Article

References (50)

1. J.M. Rowe Prognostic factors in adult acute lymphoblastic leukaemia Br J Haematol 150 2010 389 405
2. D. Hoelzer, W.D. Ludwig, and E. Thiel et al. Improved outcome in adult B-cell acute lymphoblastic leukemia Blood 87 1996 495 508
3. J.M. Rowe, G. Buck, and A.K. Burnett et al. Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993 Blood 106 2005 3760 3767
4. D. Hoelzer, E. Thiel, and H. Loffler et al. Prognostic factors in a multicenter study for treatment of acute lymphoblastic leukemia in adults Blood 71 1988 123 131
5. M. Hunault, J.L. Harousseau, and M. Delain et al. Better outcome of adult acute lymphoblastic leukemia after early genoidentical allogeneic bone marrow transplantation (BMT) than after late high-dose therapy and autologous BMT: a GOELAMS trial Blood 104 2004 3028 3037
6. H.M. Lazarus, S.M. Richards, and R. Chopra et al. Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII/ECOG E2993 Blood 108 2006 465 472
7. J.M. Bennett, D. Catovsky, and M.T. Daniel et al. The morphological classification of acute lymphoblastic leukaemia: concordance among observers and clinical correlations Br J Haematol 47 1981 553 561
8. S. Faderl, S. Jeha, and H.M. Kantarjian The biology and therapy of adult acute lymphoblastic leukemia Cancer 98 2003 1337 1354
9. A.V. Moorman, L. Chilton, J. Wilkinson, H.M. Ensor, N. Bown, and S.J. Proctor A population-based cytogenetic study of adults with acute lymphoblastic leukemia Blood 115 2010 206 214
10. J.I. Sive, G. Buck, and A. Fielding et al. Outcomes in older adults with acute lymphoblastic leukaemia (ALL): results from the international MRC UKALL XII/ECOG2993 trial Br J Haematol 157 2012 463 471
11. C.D. Baldus, P. Martus, and T. Burmeister et al. Low ERG and BAALC expression identifies a new subgroup of adult acute T-lymphoblastic leukemia with a highly favorable outcome J Clin Oncol 25 2007 3739 3745
12. E. Coustan-Smith, C.G. Mullighan, and M. Onciu et al. Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia Lancet Oncol 10 2009 147 156
13. V. Asnafi, A. Buzyn, and N.S. Le et al. NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study Blood 113 2009 3918 3924
14. A. Kuhnl, N. Gokbuget, and A. Stroux et al. High BAALC expression predicts chemoresistance in adult B-precursor acute lymphoblastic leukemia Blood 115 2010 3737 3744
15. A.A. Ferrando The role of NOTCH1 signaling in T-ALL Hematology Am Soc Hematol Educ Program 2009 353 361
16. K. Beldjord, E. Macintyre, and V. Lheritier et al. Minimal residual disease at 3 months, combined to the presence of IKZF1 deletion in B-lineage or absence of NOTCH1 pathway mutation in T-lineage, recapitulates the disease risk assessment in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia - a GRAALL study ASH Annual Meeting Abstracts 118 2011 572
17. M. Al Khabori, S. Samiee, and S. Fung et al. Adult precursor T-lymphoblastic leukemia/lymphoma with myeloid-associated antigen expression is associated with a lower complete remission rate following induction chemotherapy Acta Haematol 120 2008 5 10
18. Aljurf M, Chaudhri NA, Almhareb F, et al. CD34 expression in adult acute lymphoblastic leukemia (ALL) is a favorable prognostic factor in patients treated with stem cell transplant in first remission. ASH Annual Meeting Abstracts 118:4091.
19. D.H. Boldt, K.J. Kopecky, D. Head, G. Gehly, J.P. Radich, and F.R. Appelbaum Expression of myeloid antigens by blast cells in acute lymphoblastic leukemia of adults: the Southwest Oncology Group experience Leukemia 8 1994 2118 2126
20. C. Boucheix, B. David, and C. Sebban et al. Immunophenotype of adult acute lymphoblastic leukemia, clinical parameters, and outcome: an analysis of a prospective trial including 562 tested patients (LALA87). French Group on Therapy for Adult Acute Lymphoblastic Leukemia Blood 84 1994 1603 1612
21. M.S. Czuczman, R.K. Dodge, and C.C. Stewart et al. Value of immunophenotype in intensively treated adult acute lymphoblastic leukemia: cancer and leukemia Group B study 8364 Blood 93 1999 3931 3939
22. H. Firat, R. Favier, and M. Adam et al. Determination of myeloid antigen expression on childhood acute lymphoblastic leukaemia cells: discrepancies using different monoclonal antibody clones Leuk Lymphoma 42 2001 75 82
23. B. Gleissner, N. Goekbuget, and H. Rieder et al. CD10- pre-B acute lymphoblastic leukemia (ALL) is a distinct high-risk subgroup of adult ALL associated with a high frequency of MLL aberrations: results of the German Multicenter Trials for Adult ALL (GMALL) Blood 106 2005 4054 4056
24. F. Lauria, D. Raspadori, and G. Martinelli et al. Increased expression of myeloid antigen markers in adult acute lymphoblastic leukaemia patients: diagnostic and prognostic implications Br J Haematol 87 1994 286 292
25. S. Maury, F. Huguet, and A. Pigneux et al. Prognostic significance of CD20 expression in adult B-cell precursor acute lymphoblastic leukemia ASH Annual Meeting Abstracts 110 2007 2829
26. O. Perbellini, and M.T. Scupoli Adult T-cell acute lymphoblastic leukemia: prognostic impact of myeloid-associated antigens Expert Rev Hematol 2 2009 27 29
27. M.C. Putti, R. Rondelli, and M.G. Cocito et al. Expression of myeloid markers lacks prognostic impact in children treated for acute lymphoblastic leukemia: Italian experience in AIEOP-ALL 88-91 studies Blood 92 1998 795 801
28. D.A. Thomas, S. O'Brien, and J.L. Jorgensen et al. Prognostic significance of CD20 expression in adults with de novo precursor B-lineage acute lymphoblastic leukemia Blood 113 2009 6330 6337
29. X. Thomas, L. Vila, L. Campos, O. Sabido, and E. Archimbaud Expression of N-CAM (CD56) on acute leukemia cells: relationship with disease characteristics and outcome Leuk Lymphoma 19 1995 295 300
30. A. Vitale, A. Guarini, and C. Ariola et al. Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol Blood 107 2006 473 479
31. A. Vitale, A. Guarini, and C. Ariola et al. Absence of prognostic impact of CD13 and/or CD33 antigen expression in adult acute lymphoblastic leukemia. Results of the GIMEMA ALL 0496 trial Haematologica 92 2007 342 348
32. M.N. Yenerel, T. Atamer, and A.S. Yavuz et al. Myeloid antigen expression provides favorable outcome in patients with adult acute lymphoblastic leukemia: a single-center study Ann Hematol 81 2002 498 503
33. D. Hoelzer, E. Thiel, and H. Loffler et al. Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults Blood 64 1984 38 47
34. B. Patel, L. Rai, and G. Buck et al. Minimal residual disease is a significant predictor of treatment failure in non T-lineage adult acute lymphoblastic leukaemia: final results of the international trial UKALL XII/ECOG2993 Br J Haematol 148 2010 80 89
35. G.J. Ruiz-Arguelles, D. Fernandez-Lara, and R. Estrada-Gomez et al. Minimal residual disease testing in acute leukemia by flow cytometry immunophenotyping: prognostic significance Lab Hematol 13 2007 22 26
36. Q.H. Le, X. Thomas, and R. Ecochard et al. Initial and late prognostic factors to predict survival in adult acute lymphoblastic leukaemia Eur J Haematol 77 2006 471 479
37. M. Baccarani, G. Corbelli, and S. Amadori et al. Adolescent and adult acute lymphoblastic leukemia: prognostic features and outcome of therapy. A study of 293 patients Blood 60 1982 677 684
38. X. Thomas, E. Archimbaud, C. Charrin, J.P. Magaud, and D. Fiere CD34 expression is associated with major adverse prognostic factors in adult acute lymphoblastic leukemia Leukemia 9 1995 249 253
39. D.H. Boldt, K.J. Kopecky, D. Head, G. Gehly, J.P. Radich, and F.R. Appelbaum Expression of myeloid antigens by blast cells in acute lymphoblastic leukemia of adults: the Southwest Oncology Group experience Leukemia 8 1994 2118 2126
40. T. Raff, N. Gokbuget, and S. Luschen et al. Molecular relapse in adult standard-risk ALL patients detected by prospective MRD monitoring during and after maintenance treatment: data from the GMALL 06/99 and 07/03 trials Blood 109 2007 910 915
41. A. Dominietto, A.M. Raiola, and R. Grasso et al. Molecular relapse of acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation can be successfully treated with donor lymphocyte infusions ASH Annual Meeting Abstracts 104 2004 5122
42. M.U. Sachdeva, J. Ahluwalia, R. Das, N. Varma, and G. Garewal Role of FAB classification of acute leukemias in era of immunophenotyping Indian J Pathol Microbiol 49 2006 524 527
43. J.M. Bennett, D. Catovsky, and M.T. Daniel et al. Proposals for the classification of the acute leukaemias: French-American-British (FAB) co-operative group Br J Haematol 33 1976 451 458
44. E.S. Jaffe, N.L. Harris, J. Diebold, and H.K. Muller-Hermelink World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: a progress report Am J Clin Pathol 111 1999 S8 12
45. M. Borowitz, and J.K. Chan Precursor lymphoid neoplasms S.H. Swerdlow, E. Campo, N.L. Harris, WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues 2008 IARC Lyon, France 167 178
46. B.I. Dalal, S. Mansoor, M. Manna, S. Pi, G.D. Sauro, and D.E. Hogge Detection of CD34, TdT, CD56, CD2, CD4, and CD14 by flow cytometry is associated with NPM1 and FLT3 mutation status in cytogenetically normal acute myeloid leukemia Clin Lymphoma Myeloma Leuk 12 2012 274 279
47. F. Lacombe, F. Durrieu, and A. Briais et al. Flow cytometry CD45 gating for immunophenotyping of acute myeloid leukemia Leukemia 11 1997 1878 1886
48. G. Rothe Technical Background and Methodological Principles of Flow Cytometry Cellular Diagnostics: Basics, Methods and Clinical Applications of Flow Cytometry 2009 Karger Basel, Switzerland 53 88
49. B.I. Dalal, and N.S. Khare Flow cytometric testing for paroxysmal nocturnal hemoglobinuria: CD64 is better for gating monocytes than CD33 Cytometry B Clin Cytom 84 2012 33 36
50. A. Lahjouji, F. Bachir, S. Bennani, S. Benchekroun, and E. SA Clinical importance of myeloid antigen expression in Moroccan patients with adult B-lineage acute lymphoblastic leukemia Neoplasma 60 2013 553 560