Reversible nerve conduction block using kilohertz frequency alternating current

Neuromodulation

Volumn 17, Issue 3, 2014, Pages 242-255

  Kilgore, Kevin L ^a,b,c   Bhadra, Niloy ^c  

^a METROHEALTH MEDICAL CENTER   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^c Case Western Reserve University   (United States)

Author keywords

Electrical stimulation; high frequency; kilo hertz frequency nerve block; nerve block; pain block; spasticity block

Indexed keywords

ALTERNATING CURRENT; ELECTRIC FIELD; ELECTRIC POTENTIAL; ELECTRICAL PARAMETERS; ELECTRODE; EQUIPMENT DESIGN; HUMAN; KILOHERTZ FREQUENCY ALTERNATING CURRENT; KILOHERTZ FREQUENCY ALTERNATING CURRENT NERVE BLOCK; MATHEMATICAL MODEL; MOTOR NERVE; MUSCLE TWITCH; NERVE BLOCK; NERVE CONDUCTION; NERVE EXCITABILITY; NERVE FIBER; NERVE INJURY; NERVE MEMBRANE; NERVE POTENTIAL; NERVE STIMULATION; NONHUMAN; REVIEW; SCIATIC NERVE; SENSORY NERVE; WAVEFORM; ACTION POTENTIAL; ANALGESIA; ANIMAL; ANIMAL MODEL; BIOLOGICAL MODEL; COMPUTER SIMULATION; DEVICES; ELECTRICITY; ELECTROSTIMULATION THERAPY; OBESITY; PERIPHERAL NERVE; PHYSIOLOGY; PROCEDURES; SPINAL CORD; TRENDS; ULTRASTRUCTURE; URINATION DISORDERS;

ACTION POTENTIALS; ANIMALS; COMPUTER SIMULATION; ELECTRIC STIMULATION THERAPY; ELECTRICITY; HUMANS; MODELS, ANIMAL; MODELS, NEUROLOGICAL; NERVE FIBERS; NEURAL CONDUCTION; OBESITY; PAIN MANAGEMENT; PERIPHERAL NERVES; SPINAL CORD; URINATION DISORDERS;

EID: 84899991620     PISSN: 10947159     EISSN: 15251403     Source Type: Journal    
DOI: 10.1111/ner.12100     Document Type: Review

References (90)

1. Linderoth B, Foreman RD,. Physiology of spinal cord stimulation: review and update. Neuromodulation 1999; 2: 150-164.
2. Kilgore KL, Bhadra N,. Nerve conduction block utilising high-frequency alternating current. Med Biol Eng Comput 2004; 42: 394-406.
3. Jensen AL, Durand DM,. High frequency stimulation can block axonal conduction. Exp Neurol 2009; 220: 57-70.
4. Wodlinger B, Rashid S, Durand DM,. Block of peripheral pain response by high-frequency sinusoidal stimulation. Neuromodulation 2013; Epub ahead of print. DOI: 10.1111/ner.12032.
5. Williamson RP, Andrews BJ,. Localized electrical nerve blocking. IEEE Trans Biomed Eng 2005; 52: 362-370.
6. Dowden BR, Wark HA, Normann RA,. Muscle-selective block using intrafascicular high-frequency alternating current. Muscle Nerve 2010; 42: 339-347.
7. Whitwam JG, Kidd C,. The use of direct current to cause selective block of large fibres in peripheral nerves. Br J Anaesth 1975; 47: 1123-1133.
8. Merrill DR, Bikson M, Jefferys JG,. Electrical stimulation of excitable tissue: design of efficacious and safe protocols. J Neurosci Methods 2005; 141: 171-198.
9. Solomonow M, Eldred E, Lyman J, Foster J,. Fatigue considerations of muscle contractile force during high-frequency stimulation. Am J Phys Med 1983; 62: 117-122.
10. Boger A, Bhadra N, Gustafson KJ,. Bladder voiding by combined high frequency electrical pudendal nerve block and sacral root stimulation. Neurourol Urodyn 2008; 27: 435-439.
11. Franke M, Bhadra N, Gustafson KJ,. Chronic bladder voiding after SCI using electric HFAC pudendal nerve block. Paper presented at: Neural Interfaces Conference; June 2012, 2012; Salt Lake CIty, UT, USA.
12. Van Buyten JP, Al-Kaisy A, Smet I, Palmisani S, Smith T,. High-frequency spinal cord stimulation for the treatment of chronic back pain patients: results of a prospective multicenter European clinical study. Neuromodulation 2013; 16: 59-66.
13. Tiede J, Brown L, Gekht G, Vallejo R, Yearwood T, Morgan D,. Novel spinal cord stimulation parameters in patients with predominant back pain. Neuromodulation 2013; Epub ahead of print. DOI: 10.1111/ner.12032.
14. Bowman BR, McNeal DR,. Response of single alpha motoneurons to high-frequency pulse trains. Firing behavior and conduction block phenomenon. Appl Neurophysiol 1986; 49: 121-138.
15. Wedensky NE,. Die Erregung, Hemmung und Narkose. Pflugers Arch 1903; 100: 1.
16. Bugnard L, Hill AV,. Electric excitation of the fin nerve of sepia. J Physiol 1935; 83: 425-438.
17. Cattel M, Gerard RW,. The inhibitory effect of high-frequency stimulation and the excitation state of nerve. J Physiol 1935; 83: 407-415.
18. Reboul J, Rosenblueth A,. The blocking and deblocking effects of alternating currents on nerve. Am J Physiol 1939; 125: 251-264.
19. Tanner JA,. Reversible blocking of nerve conduction by alternating current excitation. Nature 1962; 195: 712-713.
20. Woo MY, Campbell B,. Asynchronous firing and block of peripheral nerve conduction by 20 Kc alternating current. Bull Los Angel Neuro Soc 1964; 29: 87-94.
21. Zhou BH, Baratta R, Solomonow M,. Manipulation of muscle force with various firing rate and recruitment control strategies. IEEE Trans Biomed Eng 1987; 34: 128-139.
22. Baratta R, Ichie M, Hwang SK, Solomonow M,. Orderly stimulation of skeletal muscle motor units with tripolar nerve cuff electrode. IEEE Trans Biomed Eng 1989; 36: 836-843.
23. Shaker HS, Tu LM, Robin S, et al. Reduction of bladder outlet resistance by selective sacral root stimulation using high-frequency blockade in dogs: an acute study. J Urol 1998; 160 (3 Pt 1): 901-907.
24. Hassouna M, Li JS, Sawan M, Duval F, Latt R, Elhilali MM,. Effect of early bladder stimulation on spinal shock: experimental approach. Urology 1992; 40: 563-573.
25. Li JS, Hassouna M, Sawan M, Duval F, Elhilali MM,. Long-term effect of sphincteric fatigue during bladder neurostimulation. J Urol 1995; 153: 238-242.
26. Sawan M, Hassouna MM, Li JS, Duval F, Elhilali MM,. Stimulator design and subsequent stimulation parameter optimization for controlling micturition and reducing urethral resistance. IEEE Trans Rehabil Eng 1996; 4: 39-46.
27. Abdel-Gawad M, Boyer S, Sawan M, Elhilali MM,. Reduction of bladder outlet resistance by selective stimulation of the ventral sacral root using high frequency blockade: a chronic study in spinal cord transected dogs. J Urol 2001; 166: 728-733.
28. Ishigooka M, Hashimoto T, Sasagawa I, Izumiya K, Nakada T,. Modulation of the urethral pressure by high-frequency block stimulus in dogs. Eur Urol 1994; 25: 334-337.
29. Tai C, Roppolo JR, de Groat WC,. Block of external urethral sphincter contraction by high frequency electrical stimulation of pudendal nerve. J Urol 2004; 172 (5 Pt 1): 2069-2072.
30. Naples GG, Mortimer JT, Scheiner A, Sweeney JD,. A spiral nerve cuff electrode for peripheral nerve stimulation. IEEE Trans Biomed Eng 1988; 35: 905-916.
31. Foldes EL, Ackermann DM, Bhadra N, Kilgore KL,. Design, fabrication and evaluation of a conforming circumpolar peripheral nerve cuff electrode for acute experimental use. J Neurosci Methods 2011; 196: 31-37.
32. Cuellar JM, Alataris K, Walker A, Yeomans DC, Antognini JF,. Effect of high-frequency alternating current on spinal afferent nociceptive transmission. Neuromodulation 2012; Epub ahead of print. DOI: 10.1111/ner.12015.
33. Waataja JJ, Tweden KS, Honda CN,. Effects of high-frequency alternating current on axonal conduction through the vagus nerve. J Neural Eng 2011; 8: 056013.
34. Bhadra N, Kilgore KL,. High-frequency electrical conduction block of mammalian peripheral motor nerve. Muscle Nerve 2005; 32: 782-790.
35. Bhadra N, Kilgore KL,. Direct current electrical conduction block of peripheral nerve. IEEE Trans Neural Syst Rehabil Eng 2004; 12: 313-324.
36. Bhadra N, Bhadra N, Kilgore K, Gustafson KJ,. High frequency electrical conduction block of the pudendal nerve. J Neural Eng 2006; 3: 180-187.
37. Joseph L, Haeffele BD, Butera RJ,. Conduction block induced by high frequency AC stimulation in unmyelinated nerves. Conf Proc IEEE Eng Med Biol Soc 2007; 2007: 1719-1722.
38. Joseph L, Butera RJ,. High-frequency stimulation selectively blocks different types of fibers in frog sciatic nerve. IEEE Trans Neural Syst Rehabil Eng 2011; 19: 550-557.
39. Bhadra N, Kilgore K, Gustafson KJ,. High frequency electrical conduction block of the pudendal nerve. J Neural Eng 2006; 3: 180-187.
40. Lin E, Kilgore KL, Bhadra N, Lahowetz EA,. Chronic high-frequency nerve block with an implanted waveform generator. Paper presented at: International Functional Electrical Stimulation Society Conference 2007; Philadelphia, PA, USA.
41. Tweden KS, Sarr MG, Camilleri M, et al. 46: Vagal Blocking for Obesity Control (VBLOC): studies of pancreatic and gastric function and safety in a porcine model. Surg Obes Relat Dis 2006; 2: 301-302.
42. Ackermann DM, Jr, Ethier C, Foldes EL, et al. Electrical conduction block in large nerves: high-frequency current delivery in the nonhuman primate. Muscle Nerve 2011; 43: 897-899.
43. Sarr MG, Billington CJ, Brancatisano R, et al. The EMPOWER study: randomized, prospective, double-blind, multicenter trial of vagal blockade to induce weight loss in morbid obesity. Obes Surg 2012; 22: 1771-1782.
44. Soin A,. Long-term human testing of high-frequency nerve block for amputation pain. Paper presented at: 16th Annual Meeting North American Neuromodulation Society; December 6 to 9, 2012; Las Vegas, NV, USA.
45. Perruchoud C, Eldabe S, Batterham AM, et al. Analgesic Efficacy of high-frequency spinal cord stimulation: a randomized double-blind placebo-controlled study. Neuromodulation 2013; [Epub ahead of print] doi: 10.1111/ner.12027.
46. Lahowetz ELBNKKL,. High frequency conduction block of sensory nerves. 12 th Annual conference of the International FUnctional Electical Stimulation Society; November 2007, 2007; Philadelphia, PA, USA.
47. Tai C, de Groat WC, Roppolo JR,. Simulation of nerve block by high-frequency sinusoidal electrical current based on the Hodgkin-Huxley model. IEEE Trans Neural Syst Rehabil Eng 2005; 13: 415-422.
48. Bhadra N, Lahowetz EA, Foldes ST, Kilgore KL,. Simulation of high-frequency sinusoidal electrical block of mammalian myelinated axons. J Comput Neurosci 2007; 22: 313-326.
49. Ackermann D, Foldes EL, Bhadra N, Kilgore KL,. Electrode design for high frequency block: effect of bipolar separation on block thresholds and the onset response. Conf Proc IEEE Eng Med Biol Soc 2009; 2009: 654-657.
50. Ackermann DM, Jr, Foldes EL, Bhadra N, Kilgore KL,. Effect of bipolar cuff electrode design on block thresholds in high-frequency electrical neural conduction block. IEEE Trans Neural Syst Rehabil Eng 2009; 17: 469-477.
51. Ackermann DM, Jr, Foldes EL, Bhadra N, Kilgore KL,. Conduction block of peripheral nerve using high-frequency alternating currents delivered through an intrafascicular electrode. Muscle Nerve 2010; 41: 117-119.
52. Miles JD, Kilgore KL, Bhadra N, Lahowetz EA,. Effects of ramped amplitude waveforms on the onset response of high-frequency mammalian nerve block. J Neural Eng 2007; 4: 390-398.
53. Gerges M, Foldes EL, Ackermann DM, Bhadra N, Bhadra N, Kilgore KL,. Frequency- and amplitude-transitioned waveforms mitigate the onset response in high-frequency nerve block. J Neural Eng 2010; 7: 066003.
54. Foldes EL, Ackermann D, Bhadra N, Kilgore KL,. Counted cycles method to quantify the onset response in high-frequency peripheral nerve block. Conf Proc IEEE Eng Med Biol Soc 2009; 2009: 614-617.
55. Ackermann DM, Jr, Bhadra N, Foldes EL, Wang XF, Kilgore KL,. Effect of nerve cuff electrode geometry on onset response firing in high-frequency nerve conduction block. IEEE Trans Neural Syst Rehabil Eng 2010; 18: 658-665.
56. Bhadra N, Foldes EL, Ackermann D, Kilgore KL,. Reduction of the onset response in high frequency nerve block with amplitude ramps from non-zero amplitudes. Conf Proc IEEE Eng Med Biol Soc 2009; 2009: 650-653.
57. Gaunt RA, Prochazka A,. Transcutaneously coupled, high-frequency electrical stimulation of the pudendal nerve blocks external urethral sphincter contractions. Neurorehabil Neural Repair 2009; 23: 615-626.
58. Joseph L, Butera RJ,. Unmyelinated aplysia nerves exhibit a nonmonotonic blocking response to high-frequency stimulation. IEEE Trans Neural Syst Rehabil Eng 2009; 17: 537-544.
59. Tai C, de Groat WC, Roppolo JR,. Simulation analysis of conduction block in unmyelinated axons induced by high-frequency biphasic electrical currents. IEEE Trans Biomed Eng 2005; 52: 1323-1332.
60. Peng CW, Chen JJ, Lin CC, Poon PW, Liang CK, Lin KP,. High frequency block of selected axons using an implantable microstimulator. J Neurosci Methods 2004; 134: 81-90.
61. Bhadra N, Vrabec T, Bhadra N, Kilgore KL,. Response of peripheral nerve to high frequency alternating current (HFAC) nerve block applied for long durations. Paper presented at: Neural Interface Conference 2012; Salt Lake City, UT, USA.
62. Liu H, Zhu L, Tang H, Qiu T,. Effects of high frequency electrical stimulation on nerve's conduction of action potentials. Paper presented at: Biomedical Engineering and Informatics (BMEI), 2011 4th International Conference on 2011.
63. Accornero N, Bini G, Lenzi GL, Manfredi M,. Selective activation of peripheral nerve fibre groups of different diameter by triangular shaped stimulus pulses. J Physiol (Lond) 1977; 273: 539-560.
64. Petruska JC, Hubscher CH, Johnson RD,. Anodally focused polarization of peripheral nerve allows discrimination of myelinated and unmyelinated fiber input to brainstem nuclei. Exp Brain Res 1998; 121: 379-390.
65. Merrill D,. Electrical stimulation of excitable tissue: design of efficacious and safe protocols. J Neurosci Methods 2005; 141: 171.
66. Ackermann DM, Jr, Bhadra N, Foldes EL, Kilgore KL,. Conduction block of whole nerve without onset firing using combined high frequency and direct current. Med Biol Eng Comput 2011; 49: 241-251.
67. Ackermann DM, Jr, Bhadra N, Foldes EL, Kilgore KL,. Separated interface nerve electrode prevents direct current induced nerve damage. J Neurosci Methods 2011; 201: 173-176.
68. Lilly JC,. Brief, noninjurious electric waveform for stimulation of the brain. Science 1955; 121: 468.
69. McCreery DB, Agnew WF, Yuen TG, Bullara LA,. Comparison of neural damage induced by electrical stimulation with faradaic and capacitor electrodes. Ann Biomed Eng 1988; 16: 463-481.
70. Butterwick A, Vankov A, Huie P, Freyvert Y, Palanker D,. Tissue damage by pulsed electrical stimulation. IEEE Trans Biomed Eng 2007; 54: 2261-2267.
71. Vrabec T, Wainright J, Bhadra N, Bhadra N, Kilgore K,. Use of high surface area electrodes for safe delivery of direct current for nerve conduction block. Paper presented at: Meeting Abstracts 2012.
72. Cogan SF, Ehrlich J, Plante TD, et al. Sputtered iridium oxide films for neural stimulation electrodes. J Biomed Mater Res B Appl Biomater 2009; 89: 353-361.
73. Butt M, Alataris K, Walker A, Tiede A,. Histological findings using novel stimulation parameters in a caprine model. Paper presented at: European Journal of Pain Supplements 5 2011.
74. Bromm B,. Spike frequency of the nodal membrane generated by high-frequency alternating current. Pflugers Arch 1975; 353: 1-19.
75. Rattay F,. Electrical nerve stimulation: theory, experiments and applications. New York, NY: Springer Verlag, 1990.
76. Rattay F,. High frequency electrostimulation of excitable cells. J Theor Biol 1986; 123: 45-54.
77. Tai C, Guo D, Wang J, Roppolo JR, de Groat WC,. Mechanism of conduction block in amphibian myelinated axon induced by biphasic electrical current at ultra-high frequency. J Comput Neurosci 2011; 31: 615-623.
78. Zhang X, Roppolo J, de Groat W, Tai C,. Simulation analysis of nerve block by high frequency biphasic electrical current based on frankenhaeuser-huxley model. Conf Proc IEEE Eng Med Biol Soc 2005; 4: 4247-4250.
79. Zhang X, Roppolo JR, de Groat WC, Tai C,. Mechanism of nerve conduction block induced by high-frequency biphasic electrical currents. IEEE Trans Biomed Eng 2006; 53 (12 Pt 1): 2445-2454.
80. McIntyre CC, Richardson AG, Grill WM,. Modeling the excitability of mammalian nerve fibers: influence of afterpotentials on the recovery cycle. J Neurophysiol 2002; 87: 995-1006.
81. Ackermann DM, Bhadra N, Gerges M, Thomas PJ,. Dynamics and sensitivity analysis of high-frequency conduction block. J Neural Eng 2011; 8: 065007.
82. Zhang X, Roppolo JR, de Groat WC, Tai C,. Simulation analysis of conduction block in myelinated axons induced by high-frequency biphasic rectangular pulses. IEEE Trans Biomed Eng 2006; 53: 1433-1436.
83. Schwarz JR, Reid G, Bostock H,. Action potentials and membrane currents in the human node of Ranvier. Pflugers Arch 1995; 430: 283-292.
84. Elbasiouny SM, Mushahwar VK,. Modulation of motoneuronal firing behavior after spinal cord injury using intraspinal microstimulation current pulses: a modeling study. J Appl Physiol 2007; 103: 276-286.
85. Tandri H, Weinberg SH, Chang KC, et al. Reversible cardiac conduction block and defibrillation with high-frequency electric field. Sci Transl Med 2011; 3: 102ra196.
86. Bowman BR,. Electrical block of peripheral motor activity. Yugoslavia: University of Ljubljana, 1981.
87. Camilleri M, Toouli J, Herrera MF, et al. Selection of electrical algorithms to treat obesity with intermittent vagal block using an implantable medical device. Surg Obes Relat Dis 2009; 5: 224-229; discussion 229-230.
88. Camilleri M, Toouli J, Herrera MF, et al. Intra-abdominal vagal blocking (VBLOC therapy): clinical results with a new implantable medical device. Surgery 2008; 143: 723-731.
89. De Ridder D, Plazier M, Kamerling N, Menovsky T, Vanneste S,. Burst spinal cord stimulation for limb and back pain. World Neurosurg 2013; pii: S1878-8750(13)00101-0. doi: 10.1016/j.wneu.2013.01.040. [Epub ahead of print].
90. Boger AS,. Application of high frequency electrical nerve block on the efferent nerves to the lower urinary tract for bladder voiding. Cleveland, OH: Biomedical Engineering, Case Western Reserve University, 2009.