The role of lipids and uremic toxins in cardiovascular disease in CKD

Clinical and Experimental Nephrology

Volumn 18, Issue 2, 2014, Pages 255-256

  Massy, Ziad A ^a,b  

^a LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^b UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

Author keywords

Carbamylation; Cardiovascular; CKD; Lipids; Uremic toxins

Indexed keywords

APOLIPOPROTEIN E; CATALASE; CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXIDIZED LOW DENSITY LIPOPROTEIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UREMIC TOXIN; LIPOPROTEIN; TOXIN; UREMIA MIDDLE MOLECULE TOXINS;

ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CHRONIC KIDNEY DISEASE; DYSLIPIDEMIA; GLUCOSE INTOLERANCE; HUMAN; INFLAMMATION; INSULIN RESISTANCE; LIPID OXIDATION; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; REVIEW; RISK FACTOR; RISK REDUCTION; UNINEPHRECTOMY; UREMIA; CARDIOVASCULAR DISEASES; CHRONIC KIDNEY FAILURE; COMPLICATION; LIPID METABOLISM; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

CARDIOVASCULAR DISEASES; HUMANS; LIPID METABOLISM; LIPOPROTEINS; RENAL INSUFFICIENCY, CHRONIC; TOXINS, BIOLOGICAL; UREMIA;

EID: 84899980965     PISSN: 13421751     EISSN: 14377799     Source Type: Journal    
DOI: 10.1007/s10157-013-0864-y     Document Type: Review

References (8)

1. Massy ZA, de Zeeuw D. LDL cholesterol in CKD-to treat or not to treat? Kidney Int. 2013 (May 22 on line).
2. Vanholder R, De Smet R, Glorieux G, Argilés A, Baurmeister U, Brunet P, Clark W, Cohen G, De Deyn PP, Deppisch R, Descamps-Latscha B, Henle T, Jörres A, Lemke HD, Massy ZA, Passlick-Deetjen J, Rodriguez M, Stegmayr B, Stenvinkel P, Tetta C, Wanner C, Zidek W, European Uremic Toxin Work Group (EUTox). Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int. 2003;63:1934-43. (Pubitemid 36513344)
3. Massy ZA, Stenvinkel P, Drueke TB. The role of oxidative stress in chronic kidney disease. Semin Dial. 2009;22:405-8.
4. Apostolov EO, Basnakian AG, Ok E, Shah SV. Carbamylated low-density lipoprotein: nontraditional risk factor for cardiovascular events in patients with chronic kidney disease. J Ren Nutr. 2012;22(1):134-8.
5. Apostolov EO, Ray D, Savenka AV, Shah SV, Basnakian AG. Chronic uremia stimulates LDL carbamylation and atherosclerosis. J Am Soc Nephrol. 2010;21(11):1852-7.
6. Koppe L, Pillon NJ, Vella RE, Croze ML, Pelletier CC, Chambert S, Massy Z, Glorieux G, Vanholder R, Dugenet Y, Soula HA, Fouque D. Soulage CO p-Cresyl sulfate promotes insulin resistance associated with CKD. J Am Soc Nephrol. 2013;24(1):88-99.
7. D'Apolito M, Du X, Zong H, Catucci A, Maiuri L, Trivisano T, Pettoello-Mantovani M, Campanozzi A, Raia V, Pessin JE, Brownlee M, Giardino I. Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure. J Clin Invest. 2010;120(1):203-13.
8. Trécherel E, Godin C, Louandre C, Benchitrit J, Poirot S, Mazière JC, Massy ZA, Galmiche A. Upregulation of BAD, a pro-apoptotic protein of the BCL2 family, in vascular smooth muscle cells exposed to uremic conditions. Biochem Biophys Res Commun. 2012;417(1):479-83.