Did the prion protein become vulnerable to misfolding after an evolutionary divide and conquer event?

Journal of Biomolecular Structure and Dynamics

Volumn 32, Issue 7, 2014, Pages 1074-1084

  Richmond, Kacy ^a   Masterson, Patrick ^a   Ortiz, Juan Felipe ^a   Siltberg Liberles, Jessica ^a  

^a UNIVERSITY OF WYOMING   (United States)

Author keywords

conformational ensemble; evolution; gene duplication; Misfolding; Protein evolution; structural disorder

Indexed keywords

PRION PROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; NERVE PROTEIN; PRION; PRND PROTEIN, HUMAN; SPRN PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; GENE DUPLICATION; GENETIC CONSERVATION; LAST COMMON ANCESTOR; MOLECULAR EVOLUTION; MOLECULAR PHYLOGENY; PARSIMONY ANALYSIS; PREDICTION; PRION DISEASE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN MISFOLDING; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; ANIMAL; CHEMISTRY; PHYLOGENY; PRION; PROTEIN FOLDING; SPECIES DIFFERENCE;

ANIMALS; EVOLUTION, MOLECULAR; GPI-LINKED PROTEINS; NERVE TISSUE PROTEINS; PHYLOGENY; PRIONS; PROTEIN CONFORMATION; PROTEIN FOLDING; SPECIES SPECIFICITY;

EID: 84899976843     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/07391102.2013.809022     Document Type: Article

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