Identifying blood-brain-barrier selective single-chain antibody fragments

Biotechnology Journal

Volumn 9, Issue 5, 2014, Pages 664-674

  Jones, Angela R ^a   Stutz, C Christopher ^a   Zhou, Yu ^b   Marks, James D ^b   Shusta, Eric V ^a  

^a University of Wisconsin Madison   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antibody; Blood brain barrier; Brain targeting; Combinatorial screening; Phage display

Indexed keywords

ANTIGENS; BLOOD; CHAINS; ENDOTHELIAL CELLS; RATS; TISSUE CULTURE;

BINDING SELECTIVITY; BLOOD-BRAIN BARRIER; BRAIN TARGETING; CENTRAL NERVOUS SYSTEMS; COMBINATORIAL SCREENINGS; PHAGE DISPLAY; SINGLE-CHAIN ANTIBODIES; VASCULAR SELECTIVITY;

ANTIBODIES;

HYDROCORTISONE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY 15; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY 29; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY 38; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY LABELING; ANTIBODY SCREENING; ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN CELL CULTURE; DNA FINGERPRINTING; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; RAT; ANIMAL; BRAIN; CELL CULTURE; CELL SURFACE DISPLAY; CHEMISTRY; CYTOCHEMISTRY; CYTOLOGY; GENETICS; MALE; METABOLISM; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

RATTUS;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CELL SURFACE DISPLAY TECHNIQUES; CELLS, CULTURED; ENDOTHELIAL CELLS; HISTOCYTOCHEMISTRY; MALE; RATS; RATS, SPRAGUE-DAWLEY; SINGLE-CHAIN ANTIBODIES; TISSUE DISTRIBUTION;

EID: 84899974406     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201300550     Document Type: Article

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