Valproic acid promotes differentiation of hepatocyte-like cells from whole human umbilical cord-derived mesenchymal stem cells

Tissue and Cell

Volumn 46, Issue 2, 2014, Pages 127-135

  An, Su Yeon ^a   Han, Jiyou ^a   Lim, Hee Joung ^a   Park, Seo Young ^a   Kim, Ji Hyang ^b   Do, Byung Rok ^b   Kim, Jong Hoon ^a  

^a Korea University   (South Korea)

^b Hurim BioCell Inc   (South Korea)

Author keywords

AKT; Differentiation; Endoderm; ERK; Mesenchymal stem cells

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; HEPATOCYTE NUCLEAR FACTOR 1BETA; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; HEPATOCYTE NUCLEAR FACTOR 3BETA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SCATTER FACTOR RECEPTOR; TRANSCRIPTION FACTOR SOX17; VALPROIC ACID; DIFFERENTIATION ANTIGEN; ENZYME INHIBITOR;

ARTICLE; C MET GENE; CELL DIFFERENTIATION; CELL FATE; CONTROLLED STUDY; CXCR4 GENE; ENZYME ACTIVATION; ENZYME INHIBITION; EOMES GENE; FOXA1 GENE; FOXA2 GENE; GENE; GENE EXPRESSION; GSC GENE; HNF 1BETA GENE; HUMAN; HUMAN CELL; LIVER CELL; MESENCHYMAL STEM CELL; SIGNAL TRANSDUCTION; SOX17 GENE; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; MESENCHYMAL STROMA CELL; METABOLISM; UMBILICAL CORD;

ANTIGENS, DIFFERENTIATION; CELL DIFFERENTIATION; CELLS, CULTURED; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; MESENCHYMAL STROMAL CELLS; UMBILICAL CORD; VALPROIC ACID;

EID: 84899974104     PISSN: 00408166     EISSN: 15323072     Source Type: Journal    
DOI: 10.1016/j.tice.2013.12.006     Document Type: Article

References (35)

1. Aurich H., Sgodda M., Kaltwasser P., Vetter M., Weise A., Liehr T., Brulport M., Hengstler J.G., Dollinger M.M., Fleig W.E., Christ B. Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo. Gut 2009, 58:570-581.
2. Banas A., Teratani T., Yamamoto Y., Tokuhara M., Takeshita F., Osaki M., Kawamata M., Kato T., Okochi H., Ochiya T. IFATS collection: in vivo therapeutic potential of human adipose tissue mesenchymal stem cells after transplantation into mice with liver injury. Stem Cells 2008, 26:2705-2712.
3. Biswas A., Hutchins R. Embryonic stem cells. Stem Cells Dev. 2007, 16:213-222.
4. Campard D., Lysy P.A., Najimi M., Sokal E.M. Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells. Gastroenterology 2008, 134:833-848.
5. Can A., Karahuseyinoglu S. Concise review: human umbilical cord stroma with regard to the source of fetus-derived stem cells. Stem Cells 2007, 25:2886-2895.
6. Charbord P. Bone marrow mesenchymal stem cells: historical overview and concepts. Hum. Gene Ther. 2010, 21:1045-1056.
7. Chen Y., Pan R.L., Zhang X.L., Shao J.Z., Xiang L.X., Dong X.J., Zhang G.R. Induction of hepatic differentiation of mouse bone marrow stromal stem cells by the histone deacetylase inhibitor VPA. J. Cell. Mol. Med. 2009, 13:2582-2592.
8. Dhanasekaran M., Indumathi S., Harikrishnan R., Mishra R., Lissa R., Rajkumar J.S., Sudarsanam D. Human omentum fat-derived mesenchymal stem cells transdifferentiates into pancreatic islet-like cluster. Cell Biochem. Funct. 2013, 7:612-619.
9. Dominici M., Le Blanc K., Mueller I., Slaper-Cortenbach I., Marini F., Krause D., Deans R., Keating A., Prockop D., Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006, 8:315-317.
10. Dong X.J., Zhang G.R., Zhou Q.J., Pan R.L., Chen Y., Xiang L.X., Shao J.Z. Direct hepatic differentiation of mouse embryonic stem cells induced by valproic acid and cytokines. World J. Gastroenterol. 2009, 15:5165-5175.
11. Forte G., Minieri M., Cossa P., Antenucci D., Sala M., Gnocchi V., Fiaccavento R., Carotenuto F., De Vito P., Baldini P.M., Part M., Di Nardo P. Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation. Stem Cells 2006, 24:23-33.
12. Gottlicher M., Minucci S., Zhu P., Kramer O.H., Schimpf A., Giavara S., Sleeman J.P., Lo Coco F., Nervi C., Pelicci P.G., Heinzel H. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J. 2001, 20:6969-6978.
13. Gruber H.E., Somayaji S., Riley F., Hoelscher G.L., Norton H.J., Ingram J., Hanley E.N. Human adipose-derived mesenchymal stem cells: serial passaging, doubling time and cell senescence. Biotech. Histochem. 2012, 87:303-311.
14. Gul H., Marquez-Curtis L.A., Jahroudi N., Lo J., Turner A.R., Janowska-Wieczorek A. Valproic acid increases CXCR4 expression in hematopoietic stem/progenitor cells by chromatin remodeling. Stem Cells Dev. 2009, 18:831-838.
15. Gupta P.K., Das A.K., Chullikana A., Majumdar A.S. Mesenchymal stem cells for cartilage repair in osteoarthritis. Stem Cell Res. Ther. 2012, 3:25-33.
16. Heijnen C.J., Witt O., Wulffraat N., Kulozik A.E. Stem cells in pediatrics: state of the art and future perspectives. Pediatr. Res. 2012, 71:407-409.
17. Huangfu D., Osafune K., Maehr R., Guo W., Eijkelenboom A., Chen S., Muhlestein W., Melton D.A. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat. Biotechnol. 2008, 26:1269-1275.
18. Jaiswal R.K., Jaiswal N., Bruder S.P., Mbalaviele G., Marshak D.R., Pittenger M.F. Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase. J. Biol. Chem. 2000, 275:9645-9652.
19. Kim J.H., Auerbach J.M., Rodriguez-Gomez J.A., Velasco I., Gavin D., Lumelsky N., Lee S.H., Nguyen J., Sanchez-Pernaute R., Bankiewicz K., et al. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 2002, 418:50-56.
20. Kim J.H., Panchision D., Kittappa R., McKay R. Generating CNS neurons from embryonic, fetal, and adult stem cells. Methods Enzymol. 2003, 365:303-327.
21. King C.C., Beattie G.M., Lopez A.D., Hayek A. Generation of definitive endoderm from human embryonic stem cells cultured in feeder layer-free conditions. Regen. Med. 2008, 3:175-180.
22. Kopper O., Benvenisty N. Stepwise differentiation of human embryonic stem cells into early endoderm derivatives and their molecular characterization. Stem Cell Res. 2012, 8:335-345.
23. Liu J., Ashton M.P., Sumer H., O'Bryan M.K., Brodnicki T.C., Verma P.J. Generation of stable pluripotent stem cells from NOD mouse tail-tip fibroblasts. Diabetes 2011, 60:1393-1398.
24. Pelaez D., Arita N., Cheung H.S. Extracellular signal-regulated kinase (ERK) dictates osteogenic and/or chondrogenic lineage commitment of mesenchymal stem cells under dynamic compression. Biochem. Biophys. Res. Commun. 2012, 417:1286-1291.
25. Rodrigues M., Griffith L.G., Wells A. Growth factor regulation of proliferation and survival of multipotential stromal cells. Stem Cell Res. Ther. 2010, 1:32.
26. Seo M.J., Suh S.Y., Bae Y.C., Jung J.S. Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo. Biochem. Biophys. Res. Commun. 2005, 328:258-264.
27. Shim J.H., Kim S.E., Woo D.H., Kim S.K., Oh C.H., McKay R., Kim J.H. Directed differentiation of human embryonic stem cells towards a pancreatic cell fate. Diabetologia 2007, 50:1228-1238.
28. Snykers S., De Kock J., Rogiers V., Vanhaecke T. In vitro differentiation of embryonic and adult stem cells into hepatocytes: state of the art. Stem Cells 2009, 27:577-605.
29. Snykers S., Vanhaecke T., De Becker A., Papeleu P., Vinken M., Van Riet I., Rogiers V. Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow. BMC Dev. Biol. 2007, 7:24-38.
30. Takenaga M., Fukumoto M., Hori Y. Regulated nodal signaling promotes differentiation of the definitive endoderm and mesoderm from ES cells. J. Cell Sci. 2007, 120:2078-2090.
31. Talens-Visconti R., Bonora A., Jover R., Mirabet V., Carbonell F., Castell J.V., Gomez-Lechon M.J. Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells. World J. Gastroenterol. 2006, 12:5834-5845.
32. Tsai L.K., Leng Y., Wang Z., Leeds P., Chuang D.M. The mood stabilizers valproic acid and lithium enhance mesenchymal stem cell migration via distinct mechanisms. Neuropsychopharmacology 2010, 35:2225-2237.
33. Undale A.H., Westendorf J.J., Yaszemski M.J., Khosla S. Mesenchymal stem cells for bone repair and metabolic bone diseases. Mayo Clin. Proc. 2009, 84:893-902.
34. Woo D.H., Kim S.K., Lim H.J., Heo J., Park H.S., Kang G.Y., Kim S.E., You H.J., Hoeppner D.J., Kim Y., Kwon H., Choi T.H., Lee J.H., Hong S.H., Song K.W., Ahn E.K., Chenoweth J.G., Tesar P.J., McKay R., Kim J.H. Direct and indirect contribution of human embryonic stem cell-derived hepatocyte-like cells to liver repair in mice. Gastroenterology 2012, 142:602-611.
35. Zhang H., Zhang B., Tao Y., Cheng M., Hu J., Xu M., Chen H. Isolation and characterization of mesenchymal stem cells from whole human umbilical cord applying a single enzyme approach. Cell Biochem. Funct. 2012, 30:643-649.