Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 11, 2014, Pages 2508-2511

  Mori, Mattia ^a,b   Moraca, Francesca ^a   Deodato, Davide ^a   Ferraris, Davide M ^c   Selchow, Petra ^d   Sander, Peter ^d,e   Rizzi, Menico ^a,c   Botta, Maurizio ^a,f  

^a UNIVERSITY OF SIENA   (Italy)

^b ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^c UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e Swiss National Reference Centre for Mycobacteria   (Switzerland)

^f TEMPLE UNIVERSITY   (United States)

Author keywords

Enzyme inhibitors; Metalloproteases; Tuberculosis; Virtual screening; Zmp1

Indexed keywords

BCG VACCINE; MEMBRANE METALLOENDOPEPTIDASE; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; UNCLASSIFIED DRUG; ZINC METALLOPROTEASE 1; ZINC METALLOPROTEASE 1 INHIBITOR; ZTB 12; ZTB 19; ZTB 20; ZTB 21; ZTB 22; ZTB 23; ZTB 24; ZTB 25; ZTB 26; ZTB 27; BACTERIAL PROTEIN; MOLECULAR LIBRARY; PROTEINASE INHIBITOR; ZMP1 PROTEIN, MYCOBACTERIUM TUBERCULOSIS;

ARTICLE; COMPUTER MODEL; DRUG POTENCY; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MYCOBACTERIUM TUBERCULOSIS; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; HUMAN; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

MYCOBACTERIUM TUBERCULOSIS;

BACTERIAL PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMANS; METALLOPROTEASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEPRILYSIN; PROTEASE INHIBITORS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84899968464     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.04.004     Document Type: Article

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