Crystal structure of mycobacterium tuberculosis zinc-dependent metalloprotease-1 (Zmp1), a metalloprotease involved in pathogenicity

Journal of Biological Chemistry

Volumn 286, Issue 37, 2011, Pages 32475-32482

  Ferraris, Davide M ^a   Sbardella, Diego ^b,c   Petrera, Agnese ^d   Marini, Stefano ^b   Amstutz, Beat ^d   Coletta, Massimo ^a,b   Sander, Peter ^d   Rizzi, Menico ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c Interuniversity Consortium for the Research on the Chemistry of Metals in Biological Systems   (Italy)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BIOLOGICAL FUNCTIONS; CAUSATIVE AGENTS; HOSTILE ENVIRONMENTS; HUMAN PROTEINS; M. TUBERCULOSIS; METALLO-PROTEASE; MYCOBACTERIUM TUBERCULOSIS; NEPRILYSIN; RATIONAL DESIGN; SPECIFIC INHIBITORS; STRUCTURAL CHARACTERIZATION; STRUCTURAL COMPARISON; UNIQUE FEATURES; WILD TYPES; ZINC METALLOPROTEASE;

ANTIGEN-ANTIBODY REACTIONS; ENZYMES; MACROPHAGES; PLANTS (BOTANY); RATIONAL FUNCTIONS; ZINC;

CRYSTAL STRUCTURE;

BACTERIAL ENZYME; ENDOTHELIN CONVERTING ENZYME; INFLAMMASOME; MEMBRANE METALLOENDOPEPTIDASE; METALLOPROTEINASE; PHOSPHORAMIDON; PROTEINASE; UNCLASSIFIED DRUG; ZINC DEPENDENT M13 ENDOPEPTIDASE; ZINC DEPENDENT METALLOPROTEASE 1;

ARTICLE; BACTERIAL VIRULENCE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITOR COMPLEX; ENZYME STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS; WILD TYPE;

BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; GLYCOPEPTIDES; HUMANS; METALLOPROTEASES; MYCOBACTERIUM TUBERCULOSIS; STRUCTURAL HOMOLOGY, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

BACILLI (CLASS); BACTERIA (MICROORGANISMS); EUKARYOTA; MYCOBACTERIUM TUBERCULOSIS; PHAGO;

EID: 80052717604     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.271809     Document Type: Article

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