Loss of MHC II ubiquitination inhibits the activation and differentiation of CD4 T cells

International Immunology

Volumn 26, Issue 5, 2014, Pages 283-289

  Ishikawa, Rikiya ^a   Kajikawa, Mizuho ^b   Ishido, Satoshi ^b  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

CD86; Dendritic cells

Indexed keywords

CD18 ANTIGEN; CD4 ANTIGEN; INTERLEUKIN 12; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; CD86 ANTIGEN; HLA ANTIGEN CLASS 2; MARCH-I PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DOWN REGULATION; IMMUNE RESPONSE; LYMPHOCYTE DIFFERENTIATION; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL; UBIQUITINATION; ANIMAL; ANTIGEN PRESENTATION; CELL CULTURE; CELL DIFFERENTIATION; COCULTURE; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM; TRANSGENIC MOUSE;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD18; ANTIGENS, CD86; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; DENDRITIC CELLS; DOWN-REGULATION; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS II; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; MICE, KNOCKOUT; MICE, TRANSGENIC; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84899949353     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxt066     Document Type: Article

References (13)

1. Neefjes, J., Jongsma, M. L., Paul, P. and Bakke, O. 2011. Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nat. Rev. Immunol. 11:823.
2. Reis e Sousa, C. 2006. Dendritic cells in a mature age. Nat. Rev. Immunol. 6:476.
3. Steinman, R. M. 2007. Dendritic cells: understanding immunogenicity. Eur. J. Immunol. 37(Suppl. 1):S53.
4. Ishido, S., Goto, E., Matsuki, Y. and Ohmura-Hoshino, M. 2009. E3 ubiquitin ligases for MHC molecules. Curr. Opin. Immunol. 21:78.
5. Moffat, J. M., Mintern, J. D. and Villadangos, J. A. 2013. Control of MHC II antigen presentation by ubiquitination. Curr. Opin. Immunol. 25:109.
6. Matsuki, Y., Ohmura-Hoshino, M., Goto, E. et al. 2007. Novel regulation of MHC class II function in B cells. EMBO J. 26:846.
7. Shin, J. S., Ebersold, M., Pypaert, M., Delamarre, L., Hartley, A. and Mellman, I. 2006. Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination. Nature 444:115.
8. van Niel, G., Wubbolts, R., Ten Broeke, T. et al. 2006. Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination. Immunity 25:885.
9. De Gassart, A., Camosseto, V., Thibodeau, J. et al. 2008. MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. Proc. Natl Acad. Sci. USA 105:3491.
10. Walseng, E., Furuta, K., Goldszmid, R. S., Weih, K. A., Sher, A. and Roche, P. A. 2010. Dendritic cell activation prevents MHC class II ubiquitination and promotes MHC class II survival regardless of the activation stimulus. J. Biol. Chem. 285:41749.
11. Ishido, S., Matsuki, Y., Goto, E., Kajikawa, M. and Ohmura- Hoshino, M. 2010. MARCH-I: a new regulator of dendritic cell function. Mol. Cells 29:229.
12. Ohmura-Hoshino, M., Matsuki, Y., Mito-Yoshida, M. et al. 2009. Cutting edge: requirement of MARCH-I-mediated MHC II ubiquitination for the maintenance of conventional dendritic cells. J. Immunol. 183:6893.
13. Walseng, E., Furuta, K., Bosch, B. et al. 2010. Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells. Proc. Natl Acad. Sci. USA 107:20465.