Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 11, 2014, Pages 2444-2447

  Rafferty, Stephen W ^a   Eisner, Joel R ^a   Moore, William R ^a   Schotzinger, Robert J ^a   Hoekstra, William J ^a  

^a Viamet Pharmaceuticals   (United States)

Author keywords

CYP17 lyase; Prostate cancer

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; 4 (1,2,3 TRIAZOLE); ABIRATERONE; CYTOCHROME P450 INHIBITOR; CYTOCHROME P450C17A 17,20 LYASE INHIBITOR; IMIDAZOLE; LYASE INHIBITOR; PYRIDINE; UNCLASSIFIED DRUG; VT 464; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; STEROID 17ALPHA MONOOXYGENASE; TRIAZOLE DERIVATIVE;

ARTICLE; DRUG DESIGN; HUMAN; HUMAN CELL; METAL BINDING; PHASE 2 CLINICAL TRIAL; PROSTATE CANCER; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG SCREENING; ENZYMOLOGY; MALE; METABOLISM; PROSTATIC NEOPLASMS; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; MALE; MOLECULAR STRUCTURE; PROSTATIC NEOPLASMS; RATS; STEROID 17-ALPHA-HYDROXYLASE; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84899942819     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.04.024     Document Type: Article

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