DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice

Biochemical Pharmacology

Volumn 89, Issue 3, 2014, Pages 340-348

  Takahashi Yanaga, Fumi ^a   Yoshihara, Tatsuya ^a   Jingushi, Kentaro ^a   Igawa, Kazuhiro ^b   Tomooka, Katsuhiko ^b   Watanabe, Yutaka ^c   Morimoto, Sachio ^a   Nakatsu, Yoshimichi ^a   Tsuzuki, Teruhisa ^a   Nakabeppu, Yusaku ^b   Sasaguri, Toshiyuki ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c EHIME UNIVERSITY   (Japan)

Author keywords

DIF 1; Egr 1; GSK 3 ; TCF7L2; Wnt catenin signaling pathway

Indexed keywords

ANTINEOPLASTIC AGENT; CELECOXIB; CYCLIN D1; DIFFERENTIATION INDUCING FACTOR 1; GLYCOGEN SYNTHASE KINASE 3BETA; TRANSCRIPTION FACTOR 7 LIKE 2; TRANSCRIPTION FACTOR EGR 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; COLON CANCER; CONTROLLED STUDY; DRUG ABSORPTION; ENZYME PHOSPHORYLATION; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; IN VIVO STUDY; INTESTINE TUMOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR VOLUME; TUMOR XENOGRAFT; UTERINE CERVIX CANCER; WESTERN BLOTTING; WILD TYPE;

DIF-1; EGR-1; GSK-3Β; TCF7L2; WNT/Β-CATENIN SIGNALING PATHWAY;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CYCLIN D1; DNA GLYCOSYLASES; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN SYNTHASE KINASE 3; HEXANONES; MICE; MICE, KNOCKOUT; NEOPLASMS, EXPERIMENTAL; OXIDATIVE STRESS; PHOSPHORYLATION; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN;

EID: 84899939959     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.03.006     Document Type: Article

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