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Volumn 54, Issue 1, 2014, Pages 36-42

Methylenetetrahydrofolate reductase gene variants and antipsychotic-induced weight gain and metabolic disturbances

Author keywords

A1298C; Antipsychotic; C677T; MTHFR; Weight gain

Indexed keywords

CLOZAPINE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; NEUROLEPTIC AGENT; OLANZAPINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

EID: 84899933130     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2014.03.012     Document Type: Article
Times cited : (21)

References (39)
  • 1
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: analysis and visualization of LD and haplotype maps
    • Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21(2):263-265.
    • (2005) Bioinformatics , vol.21 , Issue.2 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Daly, M.J.4
  • 2
    • 0037202751 scopus 로고    scopus 로고
    • 759C/T genetic variation of 5HT(2C) receptor and clozapine-induced weight gain
    • Basile V.S., Masellis M., De Luca V., Meltzer H.Y., Kennedy J.L. 759C/T genetic variation of 5HT(2C) receptor and clozapine-induced weight gain. Lancet 2002, 360(9347):1790-1791.
    • (2002) Lancet , vol.360 , Issue.9347 , pp. 1790-1791
    • Basile, V.S.1    Masellis, M.2    De Luca, V.3    Meltzer, H.Y.4    Kennedy, J.L.5
  • 3
    • 84874449520 scopus 로고    scopus 로고
    • Elevated homocysteine? Consider testing for folate metabolism gene variants
    • Bogolub C. Elevated homocysteine? Consider testing for folate metabolism gene variants. Minnesota Medicine 2012, 95(12):39-42.
    • (2012) Minnesota Medicine , vol.95 , Issue.12 , pp. 39-42
    • Bogolub, C.1
  • 4
    • 84873452722 scopus 로고    scopus 로고
    • Detection of metabolic syndrome in schizophrenia and implications for antipsychotic therapy: is there a role for folate?
    • Burghardt K.J., Ellingrod V.L. Detection of metabolic syndrome in schizophrenia and implications for antipsychotic therapy: is there a role for folate?. Molecular Diagnosis & Therapy 2013, 17(1):21-30.
    • (2013) Molecular Diagnosis & Therapy , vol.17 , Issue.1 , pp. 21-30
    • Burghardt, K.J.1    Ellingrod, V.L.2
  • 5
    • 84856267575 scopus 로고    scopus 로고
    • Cardiometabolic risk and the MTHFR C677T variant in children treated with second-generation antipsychotics
    • Devlin A.M., Ngai Y.F., Ronsley R., Panagiotopoulos C. Cardiometabolic risk and the MTHFR C677T variant in children treated with second-generation antipsychotics. Translational Psychiatry 2012, 2:e71.
    • (2012) Translational Psychiatry , vol.2
    • Devlin, A.M.1    Ngai, Y.F.2    Ronsley, R.3    Panagiotopoulos, C.4
  • 6
    • 0041857847 scopus 로고    scopus 로고
    • Pedigree disequilibrium tests for multilocus haplotypes
    • Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genetic Epidemiology 2003, 25(2):115-121.
    • (2003) Genetic Epidemiology , vol.25 , Issue.2 , pp. 115-121
    • Dudbridge, F.1
  • 7
    • 36849066949 scopus 로고    scopus 로고
    • Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C variants
    • Ellingrod V.L., Miller D.D., Taylor S.F., Moline J., Holman T., Kerr J. Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C variants. Schizophrenia Research 2008, 98(1-3):47-54.
    • (2008) Schizophrenia Research , vol.98 , Issue.1-3 , pp. 47-54
    • Ellingrod, V.L.1    Miller, D.D.2    Taylor, S.F.3    Moline, J.4    Holman, T.5    Kerr, J.6
  • 8
    • 84857911892 scopus 로고    scopus 로고
    • Risk factors associated with metabolic syndrome in bipolar and schizophrenia subjects treated with antipsychotics: the role of folate pharmacogenetics
    • Ellingrod V.L., Taylor S.F., Dalack G., Grove T.B., Bly M.J., Brook R.D., et al. Risk factors associated with metabolic syndrome in bipolar and schizophrenia subjects treated with antipsychotics: the role of folate pharmacogenetics. Journal of Clinical Psychopharmacology 2012, 32(2):261-265.
    • (2012) Journal of Clinical Psychopharmacology , vol.32 , Issue.2 , pp. 261-265
    • Ellingrod, V.L.1    Taylor, S.F.2    Dalack, G.3    Grove, T.B.4    Bly, M.J.5    Brook, R.D.6
  • 10
    • 77952888355 scopus 로고    scopus 로고
    • Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia
    • Garcia-Miss Mdel R., Perez-Mutul J., Lopez-Canul B., Solis-Rodriguez F., Puga-Machado L., Oxte-Cabrera A., et al. Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia. Journal of Psychiatric Research 2010, 44(7):441-446.
    • (2010) Journal of Psychiatric Research , vol.44 , Issue.7 , pp. 441-446
    • Garcia-Miss Mdel, R.1    Perez-Mutul, J.2    Lopez-Canul, B.3    Solis-Rodriguez, F.4    Puga-Machado, L.5    Oxte-Cabrera, A.6
  • 11
    • 0036499241 scopus 로고    scopus 로고
    • Sample size requirements for association studies of gene-gene interaction
    • Gauderman W.J. Sample size requirements for association studies of gene-gene interaction. American Journal of Epidemiology 2002, 155(5):478-484.
    • (2002) American Journal of Epidemiology , vol.155 , Issue.5 , pp. 478-484
    • Gauderman, W.J.1
  • 14
    • 84862022001 scopus 로고    scopus 로고
    • Association of the MTHFR gene with antipsychotic-induced metabolic abnormalities in patients with schizophrenia
    • Kuzman M.R., Müller D.J. Association of the MTHFR gene with antipsychotic-induced metabolic abnormalities in patients with schizophrenia. Pharmacogenomics 2012, 13(8):843-846.
    • (2012) Pharmacogenomics , vol.13 , Issue.8 , pp. 843-846
    • Kuzman, M.R.1    Müller, D.J.2
  • 15
    • 0026080111 scopus 로고
    • A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies
    • Lahiri D.K., Nurnberger J.I. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Research 1991, 19(19):5444.
    • (1991) Nucleic Acids Research , vol.19 , Issue.19 , pp. 5444
    • Lahiri, D.K.1    Nurnberger, J.I.2
  • 16
    • 79960752412 scopus 로고    scopus 로고
    • Pharmacogenetics of leptin in antipsychotic-associated weight gain and obesity-related complications
    • Lee A.K., Bishop J.R. Pharmacogenetics of leptin in antipsychotic-associated weight gain and obesity-related complications. Pharmacogenomics 2011, 12(7):999-1016.
    • (2011) Pharmacogenomics , vol.12 , Issue.7 , pp. 999-1016
    • Lee, A.K.1    Bishop, J.R.2
  • 17
    • 75749148791 scopus 로고    scopus 로고
    • Pharmacogenetics of antipsychotic-induced side effects
    • Lencz T., Malhotra A.K. Pharmacogenetics of antipsychotic-induced side effects. Dialogues in Clinical Neuroscience 2009, 11(4):405-415.
    • (2009) Dialogues in Clinical Neuroscience , vol.11 , Issue.4 , pp. 405-415
    • Lencz, T.1    Malhotra, A.K.2
  • 19
    • 33746257104 scopus 로고    scopus 로고
    • Homocysteine-reducing strategies improve symptoms in chronic schizophrenic patients with hyperhomocysteinemia
    • Levine J., Stahl Z., Sela B.A., Ruderman V., Shumaico O., Babushkin I., et al. Homocysteine-reducing strategies improve symptoms in chronic schizophrenic patients with hyperhomocysteinemia. Biological Psychiatry 2006, 60(3):265-269.
    • (2006) Biological Psychiatry , vol.60 , Issue.3 , pp. 265-269
    • Levine, J.1    Stahl, Z.2    Sela, B.A.3    Ruderman, V.4    Shumaico, O.5    Babushkin, I.6
  • 23
    • 70449371255 scopus 로고    scopus 로고
    • Metabolic syndrome in female patients with schizophrenia treated with second generation antipsychotics: a 3-month follow-up
    • Medved V., Kuzman M.R., Jovanovic N., Grubisin J., Kuzman T. Metabolic syndrome in female patients with schizophrenia treated with second generation antipsychotics: a 3-month follow-up. Journal of Psychopharmacology 2009, 23(8):915-922.
    • (2009) Journal of Psychopharmacology , vol.23 , Issue.8 , pp. 915-922
    • Medved, V.1    Kuzman, M.R.2    Jovanovic, N.3    Grubisin, J.4    Kuzman, T.5
  • 24
    • 33748998982 scopus 로고    scopus 로고
    • Genetics of antipsychotic treatment emergent weight gain in schizophrenia
    • Müller D.J., Kennedy J.L. Genetics of antipsychotic treatment emergent weight gain in schizophrenia. Pharmacogenomics 2006, 7(6):863-887.
    • (2006) Pharmacogenomics , vol.7 , Issue.6 , pp. 863-887
    • Müller, D.J.1    Kennedy, J.L.2
  • 25
    • 20144388485 scopus 로고    scopus 로고
    • The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia
    • Müller D.J., Klempan T.A., De Luca V., Sicard T., Volavka J., Czobor P., et al. The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia. Neuroscience Letters 2005, 379(2):81-89.
    • (2005) Neuroscience Letters , vol.379 , Issue.2 , pp. 81-89
    • Müller, D.J.1    Klempan, T.A.2    De Luca, V.3    Sicard, T.4    Volavka, J.5    Czobor, P.6
  • 27
    • 31544442693 scopus 로고    scopus 로고
    • Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis
    • Muntjewerff J.W., Kahn R.S., Blom H.J., den Heijer M. Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. Molecular Psychiatry 2006, 11(2):143-149.
    • (2006) Molecular Psychiatry , vol.11 , Issue.2 , pp. 143-149
    • Muntjewerff, J.W.1    Kahn, R.S.2    Blom, H.J.3    den Heijer, M.4
  • 28
    • 33749494516 scopus 로고    scopus 로고
    • A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism
    • Reed M.C., Nijhout H.F., Neuhouser M.L., Gregory J.F., Shane B., James S.J., et al. A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. The Journal of Nutrition 2006, 136(10):2653-2661.
    • (2006) The Journal of Nutrition , vol.136 , Issue.10 , pp. 2653-2661
    • Reed, M.C.1    Nijhout, H.F.2    Neuhouser, M.L.3    Gregory, J.F.4    Shane, B.5    James, S.J.6
  • 31
    • 77951098236 scopus 로고    scopus 로고
    • A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia
    • Tiwari A.K., Zai C.C., Likhodi O., Lisker A., Singh D., Souza R.P., et al. A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia. Neuropsychopharmacology 2010, 35(6):1315-1324.
    • (2010) Neuropsychopharmacology , vol.35 , Issue.6 , pp. 1315-1324
    • Tiwari, A.K.1    Zai, C.C.2    Likhodi, O.3    Lisker, A.4    Singh, D.5    Souza, R.P.6
  • 32
    • 84877816906 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase: biochemical characterization and medical significance
    • Trimmer E.E. Methylenetetrahydrofolate reductase: biochemical characterization and medical significance. Current Pharmaceutical Design 2013, 19(14):2574-2593.
    • (2013) Current Pharmaceutical Design , vol.19 , Issue.14 , pp. 2574-2593
    • Trimmer, E.E.1
  • 33
    • 77955471578 scopus 로고    scopus 로고
    • MTHFR genotype and differential evolution of metabolic parameters after initiation of a second generation antipsychotic: an observational study
    • van Winkel R., Moons T., Peerbooms O., Rutten B., Peuskens J., Claes S., et al. MTHFR genotype and differential evolution of metabolic parameters after initiation of a second generation antipsychotic: an observational study. International Clinical Psychopharmacology 2010, 25(5):270-276.
    • (2010) International Clinical Psychopharmacology , vol.25 , Issue.5 , pp. 270-276
    • van Winkel, R.1    Moons, T.2    Peerbooms, O.3    Rutten, B.4    Peuskens, J.5    Claes, S.6
  • 35
    • 0036159250 scopus 로고    scopus 로고
    • Clozapine, olanzapine, risperidone, and haloperidol in the treatment of patients with chronic schizophrenia and schizoaffective disorder
    • Volavka J., Czobor P., Sheitman B., Lindenmayer J.P., Citrome L., McEvoy J.P., et al. Clozapine, olanzapine, risperidone, and haloperidol in the treatment of patients with chronic schizophrenia and schizoaffective disorder. The American Journal of Psychiatry 2002, 159(2):255-262.
    • (2002) The American Journal of Psychiatry , vol.159 , Issue.2 , pp. 255-262
    • Volavka, J.1    Czobor, P.2    Sheitman, B.3    Lindenmayer, J.P.4    Citrome, L.5    McEvoy, J.P.6
  • 37
    • 14644417140 scopus 로고    scopus 로고
    • Clozapine: weight gain in a pair of monozygotic twins concordant for schizophrenia and mild mental retardation
    • Wehmeier P.M., Gebhardt S., Schmidtke J., Remschmidt H., Hebebrand J., Theisen F.M. Clozapine: weight gain in a pair of monozygotic twins concordant for schizophrenia and mild mental retardation. Psychiatry Research 2005, 133(2-3):273-276.
    • (2005) Psychiatry Research , vol.133 , Issue.2-3 , pp. 273-276
    • Wehmeier, P.M.1    Gebhardt, S.2    Schmidtke, J.3    Remschmidt, H.4    Hebebrand, J.5    Theisen, F.M.6
  • 38
  • 39
    • 16644374783 scopus 로고    scopus 로고
    • Schizophrenia and obesity: impact of antipsychotic medications
    • Wirshing D.A. Schizophrenia and obesity: impact of antipsychotic medications. The Journal of Clinical Psychiatry 2004, 65(Suppl. 18):13-26.
    • (2004) The Journal of Clinical Psychiatry , vol.65 , Issue.SUPPL. 18 , pp. 13-26
    • Wirshing, D.A.1


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