Clevidipine compared with nitroglycerin for blood pressure control in coronary artery bypass grafting: A randomized double-blind study

Canadian Journal of Anesthesia

Volumn 61, Issue 5, 2014, Pages 398-406

  Merry, Alan F ^a,b,c   Avery, Edwin G ^d,e   Nussmeier, Nancy A ^d,f   Playford, Hugh R ^g,h   Warman, Guy R ^a   Wang, Yamei ⁱ   Sladen, Robert N ^g  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b Ascot Integrated Hospital   (New Zealand)

^c AUCKLAND CITY HOSPITAL   (New Zealand)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^f TEXAS HEART INSTITUTE   (United States)

^g College of Physicians and Surgeons Columbia University ^*  (United States)

^h WESTMEAD HOSPITAL   (Australia)

ⁱ MEDICINES COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLEVIDIPINE; GLYCERYL TRINITRATE; PLACEBO; CALCIUM CHANNEL BLOCKING AGENT; PYRIDINE DERIVATIVE; VASODILATOR AGENT;

ADULT; ADVERSE OUTCOME; AGED; ANESTHESIA INDUCTION; AORTA; AREA UNDER THE CURVE; ARTERY CATHETERIZATION; ARTICLE; BLOOD PRESSURE REGULATION; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DOUBLE BLIND PROCEDURE; FEMALE; HEART RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ARTERIAL PRESSURE; CLINICAL TRIAL; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECTS; MIDDLE AGED; MULTICENTER STUDY; PROCEDURES;

AGED; ARTERIAL PRESSURE; CALCIUM CHANNEL BLOCKERS; CORONARY ARTERY BYPASS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; HEART RATE; HUMANS; MIDDLE AGED; NITROGLYCERIN; PYRIDINES; VASODILATOR AGENTS;

EID: 84899915114     PISSN: 0832610X     EISSN: 14968975     Source Type: Journal    
DOI: 10.1007/s12630-014-0131-z     Document Type: Article

References (20)

1. Vuylsteke A, Feneck RO, Jolin-Mellgard A, et al. Perioperative blood pressure control: a prospective survey of patient management in cardiac surgery. J Cardiothorac Vasc Anesth 2000; 14: 269-73. (Pubitemid 30415924)
2. Marik PE, Varon J. Perioperative hypertension: a review of current and emerging therapeutic agents. J Clin Anesth 2009; 21: 220-9.
3. Howell SJ, Sear JW, Foex P. Hypertension, hypertensive heart disease and perioperative cardiac risk. Br J Anaesth 2004; 92: 570-83. (Pubitemid 38443862)
4. Erstad BL, Barletta JF. Treatment of hypertension in the perioperative patient. Ann Pharmacother 2000; 34: 66-79. (Pubitemid 30058926)
5. Cheung AT. Exploring an optimum intra/postoperative management strategy for acute hypertension in the cardiac surgery patient. J Card Surg 2006; 21: S8-14.
6. Haas CE, LeBlanc JM. Acute postoperative hypertension: a review of therapeutic options.Am J Health Syst Pharm 2004; 61: 1661-73.
7. Nordlander M, Sjoquist PO, Ericsson H, Ryden L. Pharmacodynamic, pharmacokinetic and clinical effects of clevidipine, an ultrashort-acting calcium antagonist for rapid blood pressure control. Cardiovasc Drug Rev 2004; 22: 227-50. (Pubitemid 39391191)
8. Kieler-Jensen N, Jolin-Mellgard A, Nordlander M, Ricksten SE. Coronary and systemic hemodynamic effects of clevidipine, an ultra-short-acting calcium antagonist, for treatment of hypertension after coronary artery surgery. Acta Anaesthesiol Scand 2000; 44: 186-93. (Pubitemid 30090268)
9. Bailey JM, Lu W, Levy JH, et al. Clevidipine in adult cardiac surgical patients: a dose-finding study. Anesthesiology 2002; 96: 1086-94. (Pubitemid 34462568)
10. Aronson S, Dyke CM, Stierer KA, et al. The ECLIPSE trials: comparative studies of clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine for acute hypertension treatment in cardiac surgery patients. Anesth Analg 2008; 107: 1110-21.
11. Singla N, Warltier DC, Gandhi SD, et al. Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2), a randomized, double-blind, placebo-controlled trial. Anesth Analg 2008; 107: 59-67.
12. Ericsson H, Fakt C, Jolin-Mellgard A, et al. Clinical and pharmacokinetic results with a new ultrashort-acting calcium antagonist, clevidipine, following gradually increasing intravenous doses to healthy volunteers. Br J Clin Pharmacol 1999; 47: 531-8. (Pubitemid 29199725)
13. Ericsson H, Bredberg U, Eriksson U, et al. Pharmacokinetics and arteriovenous differences in clevidipine concentration following a short- and a long-term intravenous infusion in healthy volunteers. Anesthesiology 2000; 92: 993-1001. (Pubitemid 30180975)
14. Stephens CT, Jandhyala BS. Effects of fenoldopam, a dopamine D-1 agonist, and clevidipine, a calcium channel antagonist, in acute renal failure in anesthetized rats. Clin Exp Hypertens 2002; 24: 301-13. (Pubitemid 34602704)
15. Kulka PJ, Tryba M, Zenz M. Preoperative alpha2-adrenergic receptor agonists prevent the deterioration of renal function after cardiac surgery: results of a randomized, controlled trial. Crit Care Med 1996; 24: 947-52. (Pubitemid 26189934)
16. Mangano CM, Diamondstone LS, Ramsay JG, Aggarwal A, Herskowitz A, Mangano DT . Renal dysfunction after myocardial revascularization: risk factors, adverse outcomes, and hospital resource utilization. The Multicenter Study of Perioperative Ischemia Research Group. Ann Intern Med 1998; 128: 194-203. (Pubitemid 28078200)
17. Merry AF, Webster CS, Mathew DJ. A new, safety-oriented, integrated drug administration and automated anesthesia record system. Anesth Analg 2001; 93: 385-90. (Pubitemid 32701536)
18. Powroznyk AV, Vuylsteke A, Naughton C, et al. Comparison of clevidipine with sodium nitroprusside in the control of blood pressure after coronary artery surgery. Eur J Anaesthesiol 2003; 20: 697-703. (Pubitemid 37047744)
19. Mack MJ, Brown PP, Kugelmass AD, et al. Current status and outcomes of coronary revascularization 1999 to 2002: 148,396 surgical and percutaneous procedures. Ann Thorac Surg 2004; 77: 761-8. (Pubitemid 38271031)
20. Ferguson TB Jr, Hammill BG, Peterson ED, DeLong ER, Grover FL, STS National Database Committee. A decade of change - risk profiles and outcomes for isolated coronary artery bypass grafting procedures, 1990-1999: a report from the STS National Database Committee and the Duke Clinical Research Institute. Society of Thoracic Surgeon. Ann Thorac Surg 2002; 73: 480-90.