Increased macrophage density of cardiac allograft biopsies is associated with antibody-mediated rejection and alloantibodies to HLA antigens

Clinical Transplantation

Volumn 28, Issue 5, 2014, Pages 554-560

  Xu, Lauren ^a   Collins, Jennifer ^a   Drachenberg, Cinthia ^a   Kukuruga, Debra ^a   Burke, Allen ^a  

^a UNIVERSITY OF MARYLAND MEDICAL CENTER   (United States)

Author keywords

Antibody mediated rejection; Cardiac allograft; Complement; Macrophages; Pathology

Indexed keywords

ALLOANTIBODY; ALLOANTIGEN; HLA ANTIGEN; IMMUNOGLOBULIN; RITUXIMAB;

ALLOGRAFT; ANTIBODY MEDIATED REJECTION; ARTICLE; CARDIAC ALLOGRAFT VASCULOPATHY; CARDIAC GRAFT REJECTION; COMPLEMENT SYSTEM; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; MACROPHAGE; MAJOR CLINICAL STUDY; PLASMAPHERESIS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; ADULT; BLOOD; COMPLICATION; DONOR; ENZYME IMMUNOASSAY; FEMALE; FLOW CYTOMETRY; FOLLOW UP; GRAFT REJECTION; HEART DISEASES; IMMUNOLOGY; INFLAMMATION; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PROGNOSIS; RISK FACTOR;

ADULT; ALLOGRAFTS; FEMALE; FLOW CYTOMETRY; FOLLOW-UP STUDIES; GRAFT REJECTION; HEART DISEASES; HEART TRANSPLANTATION; HLA ANTIGENS; HUMANS; IMMUNOENZYME TECHNIQUES; INFLAMMATION; ISOANTIBODIES; MACROPHAGES; MALE; MIDDLE AGED; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; TISSUE DONORS;

EID: 84899912690     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/ctr.12348     Document Type: Article

References (31)

1. Everitt MD, Hammond ME, Snow GL et al. Biopsy-diagnosed antibody-mediated rejection based on the proposed International Society for Heart and Lung Transplantation working formulation is associated with adverse cardiovascular outcomes after pediatric heart transplant. J Heart Lung Transplant 2012: 31: 686.
2. Taylor DO, Yowell RL, Kfoury AG, Hammond EH, Renlund DG. Allograft coronary artery disease: clinical correlations with circulating anti-HLA antibodies and the immunohistopathologic pattern of vascular rejection. J Heart Lung Transplant 2000: 19: 518.
3. Wu GW, Kobashigawa JA, Fishbein MD et al. Asymptomatic antibody-mediated rejection after heart transplantation predicts poor outcomes. J Heart Lung Transplant 2009: 28: 417.
4. Boffini M, Ricci D, Bonato R et al. C4d analysis in endomyocardial biopsies of heart transplant patients: is there a correlation with hemodynamic data? Transplant Proc 2011: 43: 1168.
5. Chantranuwat C, Qiao JH, Kobashigawa J, Hong L, Shintaku P, Fishbein MC. Immunoperoxidase staining for C4d on paraffin-embedded tissue in cardiac allograft endomyocardial biopsies: comparison to frozen tissue immunofluorescence. Appl Immunohistochem Mol Morphol 2004: 12: 166.
6. Fedrigo M, Gambino A, Benazzi E et al. Role of morphologic parameters on endomyocardial biopsy to detect sub-clinical antibody-mediated rejection in heart transplantation. J Heart Lung Transplant 2011: 30: 1381.
7. Fedrigo M, Gambino A, Tona F et al. Can C4d immunostaining on endomyocardial biopsies be considered a prognostic biomarker in heart transplant recipients? Transplantation 2010: 90: 791.
8. Fedson SE, Daniel SS, Husain AN. Immunohistochemistry staining of C4d to diagnose antibody-mediated rejection in cardiac transplantation. J Heart Lung Transplant 2008: 27: 372.
9. Hattori Y, Bucy RP, Kubota Y, Baldwin WM III, Fairchild RL. Antibody-mediated rejection of single class I MHC-disparate cardiac allografts. Am J Transplant, 2012: 12: 2017.
10. Holt DB, Liapis H, Mohanakumar T et al. Complement fragment C4d and C3d deposition in pediatric heart recipients with a positive crossmatch. J Heart Lung Transplant 2008: 27: 1073.
11. Kozakowski N, Regele H. Biopsy diagnostics in renal allograft rejection: from histomorphology to biological function. Transpl Int 2009: 22: 945.
12. Loupy A, Cazes A, Guillemain R et al. Very late heart transplant rejection is associated with microvascular injury, complement deposition and progression to cardiac allograft vasculopathy. Am J Transplant 2011: 11: 1478.
13. Lunz J, Ruppert KM, Cajaiba MM et al. Re-examination of the lymphocytotoxic crossmatch in liver transplantation: can C4d stains help in monitoring? Am J Transplant 2012: 12: 171.
14. Miller DV, Roden AC, Gamez JD, Tazelaar HD. Detection of C4d deposition in cardiac allografts: a comparative study of immunofluorescence and immunoperoxidase methods. Arch Pathol Lab Med 2010: 134: 1679.
15. Molne J, Nyberg G, Blohme I, Rydberg L, Breimer ME, Svalander CT. Glomerular C3c deposition and intravascular macrophage accumulation in early humoral renal allograft rejection signifies a poor short-term outcome. APMIS 2006: 114: 700.
16. Moseley EL, Atkinson C, Sharples LD, Wallwork J, Goddard MJ. Deposition of C4d and C3d in cardiac transplants: a factor in the development of coronary artery vasculopathy. J Heart Lung Transplant 2010: 29: 417.
17. Rodriguez ER, Skojec DV, Tan CD et al. Antibody-mediated rejection in human cardiac allografts: evaluation of immunoglobulins and complement activation products C4d and C3d as markers. Am J Transplant 2005: 5: 2778.
18. Sis B, Jhangri GS, Riopel J et al. Antibody-mediated rejection with a striking interstitial monocyte/macrophage infiltration in a renal allograft under FTY720 treatment. Am J Kidney Dis 2008: 51: 127.
19. Sis B, Grynoch R, Murray AG, Campbell P, Solez K. A new diagnostic algorithm for antibody-mediated microcirculation inflammation in kidney transplants. Am J Transplant 2012: 12: 1168.
20. Smith RN, Brousaides N, Grazette L et al. C4d deposition in cardiac allografts correlates with alloantibody. J Heart Lung Transplant 2005: 24: 1202.
21. Tan CD, Sokos GG, Pidwell DJ et al. Correlation of donor-specific antibodies, complement and its regulators with graft dysfunction in cardiac antibody-mediated rejection. Am J Transplant 2009: 9: 2075.
22. Tavora F, Munivenkatappa R, Papadimitriou J, Drachenberg C, Sailey C, Mehra M, Burke A. Endothelitis in cardiac allograft biopsy specimens: possible relationship to antibody-mediated rejection. J Heart Lung Transplant 2011: 30: 435.
23. Hammond ME, Stehlik J, Snow G et al. Utility of histologic parameters in screening for antibody-mediated rejection of the cardiac allograft: a study of 3, 170 biopsies. J Heart Lung Transplant 2005: 24: 2015.
24. Lones MA, Czer LS, Trento A, Harasty D, Miller JM, Fishbein MC. Clinical-pathologic features of humoral rejection in cardiac allografts: a study in 81 consecutive patients. J Heart Lung Transplant 1995: 14: 151.
25. Ratliff NB, McMahon JT. Activation of intravascular macrophages within myocardial small vessels is a feature of acute vascular rejection in human heart transplants. J Heart Lung Transplant 1995: 14: 338.
26. Berry GJ, Burke MM, Andersen C et al. The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation. J Heart Lung Transplant 2013: 32: 1147.
27. Berry GJ, Angelini A, Burke MM et al. The ISHLT working formulation for pathologic diagnosis of antibody-mediated rejection in heart transplantation: evolution and current status (2005-2011). J Heart Lung Transplant 2011: 30: 601.
28. Kfoury AG, Hammond ME. Controversies in defining cardiac antibody-mediated rejection: need for updated criteria. J Heart Lung Transplant 2010: 29: 389.
29. Hammond EH, Yowell RL, Nunoda S et al. Vascular (humoral) rejection in heart transplantation: pathologic observations and clinical implications. J Heart Transplant 1989: 8: 430.
30. Hammond EH, Yowell RL, Price GD et al. Vascular rejection and its relationship to allograft coronary artery disease. J Heart Lung Transplant 1992: 11: S111.
31. Revelo MP, Miller DV, Stehlik J et al. Longitudinal evaluation of microvessel density in survivors vs. nonsurvivors of cardiac pathologic antibody-mediated rejection. Cardiovasc Pathol 2012: 21: 445.