Evaluation of the efficacy of intrathecal injection of amitriptyline and doxepin in spinal anesthesia in comparison with bupivacaine in rats

Anesthesiology and Pain Medicine

Volumn 1, Issue 1, 2011, Pages 15-19

  Alebouyeh, Mahmoud Reza ^a   Imani, Farnad ^a   Rahimzadeh, Poupak ^a   Faiz, Seyyed Hamid Reza ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Amitriptyline; Bupivacaine; Doxepin; Spinal anesthesia

Indexed keywords

EID: 84899912093     PISSN: 22287523     EISSN: 22287531     Source Type: Journal    
DOI: 10.5812/kowsar.22287523.1511     Document Type: Article

References (18)

1. Chen YW, Huang KL, Liu SY, Tzeng JI, Chu KS, Lin MT, et al. Intrathecal tri-cyclic antidepressants produce spinal anesthesia. Pain. 2004;112(1-2):106-12.
2. Cheng BC, Chan BR, Chen YW, Chu KS, Cheng KI, Wang JJ, et al. Doxepin has a potent and long-acting spinal anesthetic effect in rats. Kaohsiung J Med Sci. 2006;22(2):68-74.
3. Richeimer SH, Bajwa ZH, Kahraman SS, Ransil BJ, Warfield CA. Utilization patterns of tricyclic antidepressants in a multidisciplinary pain clinic: a survey. Clin J Pain. 1997;13(4):324-9.
4. Collins SL, Moore RA, Wiffen P. Antidepressants and anticonvulsants for diabetic neuropathy and postherpetic neuralgia: a quantitative systematic review. J Pain Symptom Manage. 2000;20(6):449-58.
5. Epstein JB, Truelove EL, Oien H, Allison C, Le ND, Epstein MS. Oral topical doxepin rinse: analgesic effect in patients with oral mucosal pain due to cancer or cancer therapy. Oral Oncol. 2001;37(8):632-7.
6. Thalhammer JG, Vladimirova M, Bershadsky B, Strichartz GR. Neurologic evaluation of the rat during sciatic nerve block with lidocaine. Anesthesiology. 1995;82(4):1013-25.
7. Sudoh Y, Cahoon EE, Gerner P, Wang GK. Tricyclic antidepressants as long-acting local anesthetics. Pain. 2003;103(1-2):49-55.
8. Vohra J, Burrows G, Hunt D, Sloman G. The effect of toxic and therapeutic doses of tricyclic antidepressant drugs on intracardiac conduction. Eur J Cardiol. 1975;3(3):219-27.
9. Cohen SP, Abdi S. New developments in the use of tricyclic antidepressants for the management of pain. Curr Opin Anaesthesiol. 2001;14(5):505-11.
10. Kawamata T, Omote K, Kawamata M, Namiki A. Analgesic effect of intrathecal desipramine on carrageenan-induced thermal hyperalgesia in the rat. Br J Anaesth. 1999;83(3):449-52.
11. Haderer A, Gerner P, Kao G, Srinivasa V, Wang GK. Cutaneous analgesia after transdermal application of amitriptyline versus lidocaine in rats. Anesth Analg. 2003;96(6):1707-10.
12. Dick IE, Brochu RM, Purohit Y, Kaczorowski GJ, Martin WJ, Priest BT. Sodium channel blockade may contribute to the analgesic efficacy of antidepressants. J Pain. 2007;8(4):315-24.
13. Wordliczek J, Banach M, Dorazil M, Przewlocka B. Influence of doxepin used in preemptive analgesia on the nociception in the perioperative period. Experimental and clinical study. Pol J Pharmacol. 2001;53(3):253-61.
14. Mantel MJ, Van Riel LH, Buys Ballot AF. A rapid quantitative determination of triglycerides by means of thin-layer chromatography. Clin Chim Acta. 1975;63(3):297-302.
15. Pancrazio JJ, Kamatchi GL, Roscoe AK, Lynch C, 3rd. Inhibition of neuronal Na+ channels by antidepressant drugs. J Pharmacol Exp Ther. 1998;284(1):208-14.
16. Tai YH, Tsai RY, Lin SL, Yeh CC, Wang JJ, Tao PL, et al. Amitriptyline suppresses neuroinflammation-dependent interleukin-10-p38 mitogen-activated protein kinase-heme oxygenase-1 signaling pathway in chronic morphine-infused rats. Anesthesiology. 2009;110(6):1379-89.
17. Gerner P, Mujtaba M, Sinnott CJ, Wang GK. Amitriptyline versus bupivacaine in rat sciatic nerve blockade. Anesthesiology. 2001;94(4):661-7.
18. Ogata N, Narahashi T. Block of sodium channels by psychotropic drugs in single guinea-pig cardiac myocytes. Br J Pharmacol. 1989;97(3):905-13.