Doxepin has a potent and long-acting spinal anesthetic effect in rats

Kaohsiung Journal of Medical Sciences

Volumn 22, Issue 2, 2006, Pages 68-74

  Cheng, Bor Chin ^a   Chan, Bing Ren ^a   Chen, Yu Wen ^a   Chu, Koung Shing ^b   Cheng, Kuang I ^b   Wang, Jhi Joung ^a   Chu, Chin Chen ^a  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Anesthesia; Intrathecal; Rat; Spinal; TCA; Tricyclic antidepressant

Indexed keywords

BUPIVACAINE; DOXEPIN; LIDOCAINE; TRICYCLIC ANTIDEPRESSANT AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; EVALUATION RESEARCH; MALE; NONHUMAN; PAIN; RAT; SPINAL ANESTHESIA;

EID: 33644961205     PISSN: 02575655     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1607-551x(09)70223-2     Document Type: Article

References (16)

1. Baldessarini RJ. Drugs and the treatment of psychiatric disorders. In: Hardman JG, Limbird LE, Molinoff PB, et al, eds. The Pharmacological Basis of Therapeutics. New York: McGraw-Hill, 1995:431-59.
2. Cohen SP, Abdi S. New developments in the use of tricyclic antidepressants for the management of pain. Curr Opin Anaesthesiol 2001;14:505-11.
3. Collins SL, Moore RA, McQuay HJ, et al. Antidepressants and anticonvulsants for diabetic neuropathy and postherpetic neuralgia: A quantitative systematic review. J Pain Symptom Manag 2000;20:449-58.
4. Richeimer SH, Bajwa ZH, Kahraman SS, et al. Utilization patterns of tricyclic antidepressants in a multidisciplinary pain clinic: A survey. Clin J Pain 1997;13:324-9.
5. Staiger TO, Gaster B, Sullivan MD, et al. Systematic review of antidepressants in the treatment of chronic low back pain. Spine 2003;28:2540-5.
6. Wordliczek J, Banach M, Dorazil M, et al. Influence of doxepin used in preemptive analgesia on the nociception in the perioperative period. Experimental and clinical study. Pol J Pharmacol 2001;53:253-61.
7. Park TJ, Shin SY, Suh BC, et al. Differential inhibition of catecholamine secretion by amitriptyline through blockage of nicotinic receptors, sodium channels, and calcium channels in bovine adrenal chromaffin cells. Synapse 1998;29:248-56.
8. + channels by antidepressant drugs. J Pharmacol Exp Ther 1998;284:208-14.
9. Sudoh Y, Cahoon EE, De Girolami U, et al. Local anesthetic properties of a novel derivative, N-methyl doxepin, versus doxepin and bupivacaine. Anesth Analg 2004;98:672-6.
10. Strichartz GR. Neural physiology and local anesthetic action. In: Cousins MJ, Bridenbaugh PO, eds. Neural Blockade in Clinical Anesthesia and Management of Pain. New York: Lippincott-Raven, 1998:35-54.
11. Sudoh Y, Cahoon EE, Gerner P, et al. Tricyclic antidepressants as long-acting local anesthetics. Pain 2003;103:49-55.
12. Chen YW, Huang KL, Liu SY, et al. Intrathecal tricyclic antidepressants produce spinal anesthesia. Pain 2004;112: 106-12.
13. Gerner P, Nakamura T, Quan CF, et al. Spinal tonicaine: Potency and differential blockade of sensory and motor functions. Anesthesiology 2000;92:1350-60.
14. + currents in rats sensory neurons in vitro. J Pharmacol Exp Ther 2001;299: 705-11.
15. McCleane GJ. Topical doxepin hydrochloride reduces neuropathic pain: A randomized, double-blind, placebo-controlled study. Pain Clin 2000;12:47-50.
16. Richeimer SH, Bajwa ZH, Kahraman SS, et al. Utilization patterns of tricyclic antidepressants in multidisciplinary pain clinic: A survey. Clin J Pain 1997;13:324-9.