High HIV incidence in the postpartum period sustains vertical transmission in settings with generalized epidemics: A cohort study in Southern Mozambique

Journal of the International AIDS Society

Volumn 17, Issue , 2014, Pages

  De Schacht, Caroline ^a   Mabunda, Nédio ^b   Ferreira Jr , Orlando C ^c   Ismael, Nália ^b   Calú, Nurbai ^d   Santos, Iolanda ^e   Hoffman, Heather J ^f   Alons, Catharina ^a   Guay, Laura ^a,f   Jani, Ilesh V ^b  

^a ELIZABETH GLASER PEDIATRIC AIDS FOUNDATION   (United States)

^b INSTITUTO NACIONAL DE SAÚDE   (Mozambique)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^d Provincial Health Directorate Gaza   (Mozambique)

^e Provincial Health Directorate Maputo   (Mozambique)

^f GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

Breastfeeding; Elimination paediatric HIV; HIV; Incidence; Mozambique; PMTCT

Indexed keywords

VIRUS DNA;

ADULT; AGE; ARTICLE; ATTITUDE TO HEALTH; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; COMMERCIAL PHENOMENA; CONDOM USE; CONTROLLED STUDY; DELIVERY; DIVORCED WOMAN; DOMESTIC VIOLENCE; DRIED BLOOD SPOT TESTING; EDUCATIONAL STATUS; EMPLOYEE; EMPLOYMENT; EPIDEMIC; FEMALE; FOLLOW UP; HIV TEST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCIDENCE; INFANT; INFECTION RISK; MAJOR CLINICAL STUDY; MARRIAGE; MARRIED PERSON; MEDICAL HISTORY; MINER; MOZAMBIQUE; PARITY; POLYGAMY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGENY; PROSPECTIVE STUDY; PUERPERIUM; RISK ASSESSMENT; RURAL POPULATION; SELF EVALUATION; SEPARATED PERSON; SEROCONVERSION; SEXUAL BEHAVIOR; SEXUAL VIOLENCE; SEXUALLY TRANSMITTED DISEASE; STRUCTURED QUESTIONNAIRE; UNEMPLOYMENT; VAGINAL DRYNESS; VERTICAL TRANSMISSION; WIDOWED PERSON;

BREASTFEEDING; ELIMINATION PAEDIATRIC HIV; HIV; INCIDENCE; MOZAMBIQUE; PMTCT;

ADOLESCENT; FEMALE; HIV INFECTIONS; HUMANS; INCIDENCE; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MOZAMBIQUE; POSTPARTUM PERIOD; PREGNANCY; PROSPECTIVE STUDIES; RISK FACTORS; YOUNG ADULT;

EID: 84899857773     PISSN: None     EISSN: 17582652     Source Type: Journal    
DOI: 10.7448/IAS.17.1.18808     Document Type: Article

References (28)

1. UNAIDS. Global report. UNAIDS report on the global AIDS epidemic 2013. Geneva: Joint United Nations Programme on HIV/AIDS; 2013.
2. Johnson LF, Stinson K, Newell ML, Bland RM, Moultrie H, Davies MA, et al. The contribution of maternal HIV seroconversion during late pregnancy and breastfeeding to mother-to-child transmission of HIV. J Acquir Immune Defic Syndr. 2012;59(4):417-25.
3. Moodley D, Esterhuizen T, Reddy L, Moodley P, Singh B, Ngaleka L, et al. Incident HIV infection in pregnant and lactating women and its effect on mother-to-child transmission in South Africa. J Infect Dis. 2011;203(9):1231-4.
4. Liang K, Gui X, Zhang YZ, Zhuang K, Meyers K, Ho DD. A case series of 104 women infected with HIV-1 via blood transfusion postnatally: high rate of HIV-1 transmission to infants through breast-feeding. J Infect Dis. 2009;200(5):682-6.
5. WHO. PMTCT strategic vision 2010-2015: preventing mother-to-child transmission of HIV to reach the UNGASS and Millenium Development Goals. Geneva: World Health Organization; 2010.
6. Kinuthia J, Kiarie JN, Farquhar C, Richardson B, Nduati R, Mbori-Ngacha D, et al. Cofactors for HIV-1 incidence during pregnancy and postpartum period. Curr HIV Res. 2010;8(7):510-4.
7. Munjoma MW, Mhlanga FG, Mapingure MP, Kurewa EN, Mashavave GV, Chirenje MZ, et al. The incidence of HIV among women recruited during late pregnancy and followed up for six years after childbirth in Zimbabwe. BMC Public Health. 2010;10:668.
8. Instituto Nacional de Saúde (INS), Instituto Nacional de Estatística (INE), e ICF Macro. 2010. Inquérito Nacional de Prevalência, Riscos Comportamentais e Informação sobre o HIV e SIDA em Moçambique 2009. Calverton, Maryland, EUA: INS, INE e ICF Macro.
9. Instituto Nacional de Saúde (INS), Instituto Nacional de Estatística (INE), Grupo Técnico Multisectorial de Combate ao HIV/SIDA (GTM). 2011. Vigilância Epidemiológica do HIV e seu Impacto Demográfico em Moçambique: Actualização, Ronda 2009. Maputo, Moçambique: GTM.
10. CNCS. Global AIDS response progress report Mozambique (2010-2011) [Internet]. 2012. [cited 2013 Mar 23]. Available from: http://www.cncs.org.mz/ index.php/por/Publicacoes/Planos-e-Relatorios/Relatorios-do-CNCS.
11. UNAIDS. Global plan towards the elimination of new HIV infections among children by 2015 and keeping their mothers alive [Internet]. 2011. [cited 2013 Oct 20]. Available from: http://www.unaids.org/en/media/unaids/contentassets/ documents/unaidspublication/2011/20110609-JC2137-Global-Plan-Elimination-HIV- Children-en.pdf.
12. INE. Census data 2007 [Internet]. 2007. [cited 2013 Jan 15]. Available from: http://www.ine.gov.mz/DataAnalysis.aspx.
13. INE. Multiple indicator cluster survey [Internet]. 2008. [cited 2013 Jan 15]. Available from: http://www.unicef.org/mozambique/MICS-Summary-English- 201009.pdf.
14. Humphrey JH, Marinda E, Mutasa K, Moulton LH, Iliff PJ, Ntozini R, et al. Mother to child transmission of HIV among Zimbabwean women who seroconverted postnatally: prospective cohort study. BMJ. 2010;341:c6580.
15. Leroy V, Van de Perre P, Lepage P, Saba J, Nsengumuremyi F, Simonon A, et al. Seroincidence of HIV-1 infection in African women of reproductive age: a prospective cohort study in Kigali, Rwanda, 1988-1992. AIDS. 1994;8(7):983-6. (Pubitemid 24206610)
16. Gray RH, Li X, Kigozi G, Serwadda D, Brahmbhatt H, Wabwire-Mangen F, et al. Increased risk of incident HIV during pregnancy in Rakai, Uganda: a prospective study. Lancet. 2005;366(9492):1182-8. (Pubitemid 41393596)
17. Lu L, Legwaila K, Motswere C, Smit M, Jimbo W, Creek T. HIV incidence in pregnancy and the first post-partum year and implications for PMTCT programs, Francistown, Botswana, 2008. 16th Conference on Retroviruses and Opportunistic Infections Abstract #91. Montreal, Canada; 8-11 February 2009.
18. Mepham S, Bland R, Ndirangu J, Newell ML. HIV incidence and associated socio-economic factors in a prospective cohort of antenatal and postpartum women in rural, Northern KwaZulu-Natal. 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Abstract #CDC077. Cape Town, South Africa: International AIDS Society; 19-22 July 2009.
19. Kieffer MP, Nhlabatsi B, Mahdi M, Hoffman HJ, Kudiabor K, Wilfert CM. Improved detection of incident HIV infection and uptake of PMTCT services in labor and delivery in a high HIV prevalence setting. J Acquir Immune Defic Syndr. 2011;57(4):e85-91.
20. Brown T, Bao L, Raftery AE, Salomon JA, Baggaley RF, Stover J, et al. Modelling HIV epidemics in the antiretroviral era: the UNAIDS estimation and projection package 2009. Sex Transm Infect. 2010;86(Suppl 2):ii3-10.
21. Mbizvo MT, Kasule J, Mahomed K, Nathoo K. HIV-1 seroconversion incidence following pregnancy and delivery among women seronegative at recruitment in Harare, Zimbabwe. Cent Afr J Med. 2001;47(5):115-8. (Pubitemid 33794027)
22. Ramjee G, Wand H, Whitaker C, McCormack S, Padian N, Kelly C, et al. HIV incidence among non-pregnant women living in selected rural, semi-rural and urban areas in Kwazulu-Natal, South Africa. AIDS Behav. 2012;16(7):2062-71.
23. Marston M, Becquet R, Zaba B, Moulton LH, Gray G, Coovadia H, et al. Net survival of perinatally and postnatally HIV-infected children: a pooled analysis of individual data from sub-Saharan Africa. Int J Epidemiol. 2011;40(2):385-96.
24. WHO. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. Recommendations for a public health approach. Geneva: WHO; 2013.
25. WHO. Programmatic update - use of antiretroviral drugs for treating pregnant women and preventing HIV infection in infants. Geneva: WHO; 2012.
26. Mugo NR, Heffron R, Donnell D,Wald A,Were EO, Rees H, et al. Increased risk of HIV-1 transmission in pregnancy: a prospective study among African HIV-1-serodiscordant couples. AIDS. 2001;25(15):1887-95.
27. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493-505.
28. Cohen J. Breakthrough of the year. HIV treatment as prevention. Science. 2011;334(6063):1628.