Increased risk of HIV-1 transmission in pregnancy: A prospective study among African HIV-1-serodiscordant couples

AIDS

Volumn 25, Issue 15, 2011, Pages 1887-1895

  Mugo, Nelly R ^a,b,c   Heffron, Renee ^c   Donnell, Deborah ^d   Wald, Anna ^c,d   Were, Edwin O ^e   Rees, Helen ^f   Celum, Connie ^c   Kiarie, James N ^a,b,c   Cohen, Craig R ^g   Kayintekore, Kayitesi ^h   Baeten, Jared M ^c  

^a UNIVERSITY OF NAIROBI   (Kenya)

^b UNIVERSITY OF NAIROBI   (Kenya)

^c UNIVERSITY OF WASHINGTON   (United States)

^d Fred Hutchinson Cancer Research Center   (United States)

^e MOI UNIVERSITY   (Kenya)

^f UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h Rwanda Zambia HIV Research Group   (Rwanda)

Author keywords

Africa; heterosexual; HIV 1 transmission; pregnancy; serodiscordant

Indexed keywords

ADULT; AFRICA; ARTICLE; BEHAVIOR CHANGE; CLINICAL EVALUATION; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN RELATION; INCIDENCE; MAJOR CLINICAL STUDY; MALE; PREGNANCY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; SEXUAL BEHAVIOR; VIRUS TRANSMISSION;

ADULT; AFRICA SOUTH OF THE SAHARA; ANTIBODIES, VIRAL; CONFIDENCE INTERVALS; FEMALE; HEALTH KNOWLEDGE, ATTITUDES, PRACTICE; HIV SEROPOSITIVITY; HIV-1; HUMANS; INCIDENCE; MALE; ODDS RATIO; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PROSPECTIVE STUDIES; SEXUAL BEHAVIOR; SEXUAL PARTNERS;

EID: 80052950992     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32834a9338     Document Type: Article

References (32)

1. UNAIDS/WHO. AIDS epidemic update 2009. http://www.unaids.org/ean/ KnowledgeCentre/HIVData/EpiUpdate/EpiUpd-Archive/2009/default.asp. [Accessed 4 April 2010]
2. Sheffield JS, Wendel GD Jr, McIntire DD, Norgard MV. The effect of progesterone levels and pregnancy on HIV-1 coreceptor expression. Reprod Sci 2009; 16:20-31.
3. Benki S, Mostad SB, Richardson BA, Mandaliya K, Kreiss JK, Overbaugh J. Cyclic shedding of HIV-1 RNA in cervical secretions during the menstrual cycle. J Infect Dis 2004; 189:2192-2201. (Pubitemid 38757191)
4. Taha TE, Dallabetta GA, Hoover DR, Chiphangwi JD, Mtima-valye LA, Liomba GN, et al. Trends of HIV-1 and sexually transmitted diseases among pregnant and postpartum women in urban Malawi. AIDS 1998; 12:197-203. (Pubitemid 28035161)
5. Leroy V, Van de Perre P, Lepage P, Saba J, Nsengumuremyi F, Simonon A, et al. Seroincidence of HIV-1 infection in African women of reproductive age: a prospective cohort study in Kigali, Rwanda, 1988-1992. AIDS 1994; 8:983-986. (Pubitemid 24206610)
6. Mbizvo MT, Kasule J, Mahomed K, Nathoo K. HIV-1 serocon-version incidence following pregnancy and delivery among women seronegative at recruitment in Harare, Zimbabwe. Cent Afr J Med 2001; 47:115-118. (Pubitemid 33794027)
7. Moodley D, Esterhuizen TM, Pather T, Chetty V, Ngaleka L. High HIV incidence during pregnancy: compelling reason for repeat HIV testing. AIDS 2009; 23:1255-1259.
8. Gray RH, Li X, Kigozi G, Serwadda D, Brahmbhatt H, Wabwire-Mangen F, et al. Increased risk of incident HIV during pregnancy in Rakai, Uganda: a prospective study. Lancet 2005; 366:1182-1188. (Pubitemid 41393596)
9. Morrison CS, Wang J, Van Der Pol B, Padian N, Salata RA, Richardson BA. Pregnancy and the risk of HIV-1 acquisition among women in Uganda and Zimbabwe. AIDS 2007; 21:1027-1034. (Pubitemid 46684334)
10. Reid SE, Dai JY, Wang J, Sichalwe BN, Akpomiemie G, Cowan FM, et al. Pregnancy, contraceptive use, and HIV acquisition in HPTN 039: relevance for HIV prevention trials among African women. J Acquir Immune Defic Syndr 2010; 53:606-613.
11. Dunn DT, Newell ML, Ades AE, Peckham CS. Risk of human immunodeficiency virus type 1 transmission through breastfeeding. Lancet 1992; 340:585-588.
12. World Health Organization. Antiretroviral drugs for treating pregnant women and preventing HIV infections in infants: recommendations for a public health approach-2010 version. Geneva: WHO Press; 2010. http://whqlibdoc.who.int/ publica-tions/2010/9789241599818-eng.pdf. [Accessed July 24 2011]
13. Clemetson DB, Moss GB, Willerford DM, Hensel M, Emonyi W, Holmes KK, et al. Detection of HIV DNA in cervical and vaginal secretions: prevalence and correlates among women in Nairobi, Kenya. JAMA 1993; 269:2860-2864. (Pubitemid 23157009)
14. Lingappa JR, Kahle E, Mugo N, Mujugira A, Magaret A, Baeten J, et al. Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the Partners Study. PLoS One 2009; 4:e5272.
15. Celum C, Wald A, Lingappa JR, Magaret AS, Wang RS, Mugo N, et al. Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2. N Engl J Med 2010; 362: 427-439.
16. Campbell MS, Mullins JI, Hughes JP, Celum C, Wong KG, Raugi DN, et al. Viral linkage in HIV-1 seroconverters and their partners in an HIV-1 prevention clinical trial. PLoS One 2011; 6:e16986.
17. Kinuthia J, Kiarie JN, Farquhar C, Richardson B, Nduati R, Mbori-Ngacha D, John-Stewart G. Cofactors for HIV-1 incidence during pregnancy and postpartum period. Curr HIV Res 2010; 8:510-514.
18. Moodley D, Esterhuizen T, Reddy L, Moodley P, Singh B, Ngaleka L, Govender D. Incident HIV infection in pregnant and lactating women and its effect on mother-to-child transmission in South Africa. J Infect Dis 2011; 203:1231-1234.
19. Elenkov IJ, Wilder RL, Bakalov VK, Link AA, Dimitrov MA, Fisher S, et al. IL-12, TNF-alpha, and hormonal changes during late pregnancy and early postpartum: implications for autoimmune disease activity during these times. J Clin Endocrinol Metab 2001; 86:4933-4938. (Pubitemid 33020544)
20. Maclure M. The case-crossover design: a method for studying transient effects on the risk of acute events. Am J Epidemiol 1991; 133:144-153.
21. Donnell D, Baeten JM, Kiarie J, Thomas KK, Stevens W, Cohen CR, et al. Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet 2010; 375:2092-2098.
22. Groer M, El-Badri N, Djeu J, Harrington M, Van Eepoel J. Suppression of natural killer cell cytotoxicity in postpartum women. Am J Reprod Immunol 2010; 63:209-213.
23. Reichelderfer PS, Coombs RW, Wright DJ, Cohn J, Burns DN, Cu-Uvin S, et al. Effect of menstrual cycle on HIV-1 levels in the peripheral blood and genital tract. WHS 001 Study Team. AIDS 2000; 14:2101-2107.
24. Beyeza-Kashesya J, Kaharuza F, Mirembe F, Neema S, Ekstrom AM, Kulane A. The dilemma of safe sex and having children: challenges facing HIV sero-discordant couples in Uganda. Afr Health Sci 2009; 9:2-12.
25. Strick LB, Wald A, Celum C. Management of herpes simplex virus type 2 infection in HIV type 1-infected persons. Clin Infect Dis 2006; 43:347-356. (Pubitemid 44078908)
26. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. for the HPTN 052 Study Team. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med 2011; E-published ahead of print 18 July 2011.
27. Matthews LT, Baeten JM, Celum C, Bangsberg DR. Periconcep-tion preexposure prophylaxis to prevent HIV transmission: benefits, risks, and challenges to implementation. AIDS 2010; 24:1975-1982.
28. Chasela CS, Hudgens MG, Jamieson DJ, Kayira D, Hosseinipour MC, Kourtis AP, et al. Maternal or infant antiretroviral drugs to reduce HIV-1 transmission. N Engl J Med 2010; 362:2271-2281.
29. Shapiro RL, Hughes MD, Ogwu A, Kitch D, Lockman S, Moffat C, et al. Antiretroviral regimens in pregnancy and breast-feeding in Botswana. N Engl J Med 2010; 362:2282-2294.
30. Byamugisha R, Tumwine JK, Semiyaga N, Tylleskar T. Determinants of male involvement in the prevention of mother-to-child transmission of HIV programme in Eastern Uganda: a cross-sectional survey. Reprod Health 2010; 7:12.
31. Aluisio A, Richardson BA, Bosire R, John-Stewart G, Mbori-Ngacha D, Farquhar C. Male antenatal attendance and HIV testing are associated with decreased infant HIV infection and increased HIV-free survival. J Acquir Immune Defic Syndr 2011; 56:76-82.
32. Katz DA, Kiarie JN, John-Stewart GC, Richardson BA, John FN, Farquhar C. Male perspectives on incorporating men into antenatal HIV counseling and testing. PLoS One 2009; 4:e7602.