Overexpression of DDR2 contributes to cell invasion and migration in head and neck squamous cell carcinoma

Cancer Biology and Therapy

Volumn 15, Issue 5, 2014, Pages 612-622

  Xu, Jinke ^a,b   Lu, Wei ^a   Zhang, Senlin ^b   Zhu, Chuchao ^a   Ren, Tingting ^a   Zhu, Tong ^a   Zhao, Hu ^a   Liu, Yanpu ^a   Su, Jin ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b JINLING HOSPITAL   (China)

Author keywords

DDR2; EMT; HNSCC; Hypoxia; Tumor metastasis

Indexed keywords

COLLAGEN TYPE 1; DISCOIDIN DOMAIN RECEPTOR 2; GELATINASE A; GELATINASE B; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; DISCOIDIN RECEPTOR; LECTIN RECEPTOR;

ARTICLE; CANCER CELL; CANCER TISSUE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FLOW CYTOMETRY; GENE OVEREXPRESSION; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LUNG METASTASIS; LYMPH NODE METASTASIS; METASTASIS POTENTIAL; PHENOTYPE; REAL TIME POLYMERASE CHAIN REACTION; TONGUE CANCER; ANIMAL; CELL HYPOXIA; CELL MOTION; DRUG EFFECTS; GENETICS; HEAD AND NECK TUMOR; LUNG TUMOR; LYMPH NODE; METABOLISM; METASTASIS; NUDE MOUSE; PATHOLOGY; SECONDARY; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE; TUMOR INVASION; XENOGRAFT;

ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL HYPOXIA; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; HEAD AND NECK NEOPLASMS; HETEROGRAFTS; HUMANS; LUNG NEOPLASMS; LYMPH NODES; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, MITOGEN;

EID: 84899854112     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.28181     Document Type: Article

References (37)

1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010; 60:277-300; PMID:20610543; http://dx.doi.org/10.3322/caac.20073
2. Haddad RI, Shin DM. Recent advances in head and neck cancer. N Engl J Med 2008; 359:1143-54; PMID:18784104
3. Leemans CR, Braakhuis BJ, Brakenhoff RH. The molecular biology of head and neck cancer. Nat Rev Cancer 2011; 11:9-22; PMID:21160525; http://dx.doi.org/10.1038/nrc2982
4. Ichikawa O, Osawa M, Nishida N, Goshima N, Nomura N, Shimada I. Structural basis of the collagen-binding mode of discoidin domain receptor 2. EMBO J 2007; 26:4168-76; PMID:17703188; http://dx.doi.org/10.1038/sj.emboj. 7601833 (Pubitemid 47462092)
5. Vogel WF, Abdulhussein R, Ford CE. Sensing extracellular matrix: an update on discoidin domain receptor function. Cell Signal 2006; 18:1108-16; PMID:16626936; http://dx.doi.org/10.1016/j.cellsig.2006.02.012 (Pubitemid 43674043)
6. Leitinger B, Kwan AP. The discoidin domain receptor DDR2 is a receptor for type X collagen. Matrix Biol 2006; 25:355-64; PMID:16806867; http://dx.doi.org/10.1016/j.matbio.2006.05.006 (Pubitemid 44175833)
7. Badiola I, Villacé P, Basaldua I, Olaso E. Downregulation of discoidin domain receptor 2 in A375 human melanoma cells reduces its experimental liver metastasis ability. Oncol Rep 2011; 26:971-8; PMID:21701781
8. Zhang K, Corsa CA, Ponik SM, Prior JL, Piwnica- Worms D, Eliceiri KW, Keely PJ, Longmore GD. The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis. Nat Cell Biol 2013; 15:677-87; PMID:23644467; http://dx.doi.org/10.1038/ncb2743
9. Valiathan RR, Marco M, Leitinger B, Kleer CG, Fridman R. Discoidin domain receptor tyrosine kinases: new players in cancer progression. Cancer Metastasis Rev 2012; 31:295-321; PMID:22366781; http://dx.doi.org/10.1007/s10555-012-9346- z
10. Olaso E, Ikeda K, Eng FJ, Xu L, Wang LH, Lin HC, Friedman SL. DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells. J Clin Invest 2001; 108:1369-78; PMID:11696582; http://dx.doi.org/10. 1172/JCI200112373 (Pubitemid 33107765)
11. Labrador JP, Azcoitia V, Tuckermann J, Lin C, Olaso E, Mañes S, Brückner K, Goergen JL, Lemke G, Yancopoulos G, et al. The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep 2001; 2:446-52; PMID:11375938; http://dx.doi.org/10.1093/embo-reports/ kve094 (Pubitemid 32519565)
12. Masui T, Ota I, Yook JI, Mikami S, Yane K, Yamanaka T, Hosoi H. Snail-induced epithelialmesenchymal transition promotes cancer stem celllike phenotype in head and neck cancer cells. Int J Oncol 2014; 44:693-9; PMID:24365974
13. Way TD, Huang JT, Chou CH, Huang CH, Yang MH, Ho CT. Emodin represses TWIST1-induced epithelial-mesenchymal transitions in head and neck squamous cell carcinoma cells by inhibiting the β-catenin and Akt pathways. Eur J Cancer 2014; 50:366-78; PMID:24157255; http://dx.doi.org/10.1016/j.ejca.2013.09.025
14. Thiery JP, Acloque H, Huang RYJ, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139:871-90; PMID:19945376; http://dx.doi.org/10.1016/j.cell.2009.11.007
15. Walsh LA, Nawshad A, Medici D. Discoidin domain receptor 2 is a critical regulator of epithelialmesenchymal transition. Matrix Biol 2011; 30:243-7; PMID:21477649; http://dx.doi.org/10.1016/j.matbio.2011.03.007
16. Onder TT, Gupta PB, Mani SA, Yang J, Lander ES, Weinberg RA. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res 2008; 68:3645-54; PMID:18483246; http://dx.doi.org/10.1158/0008- 5472.CAN-07-2938
17. Christiansen JJ, Rajasekaran AK. Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res 2006; 66:8319-26; PMID:16951136; http://dx.doi.org/10.1158/0008-5472.CAN-06-0410 (Pubitemid 44449137)
18. Kang Y, Massagué J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 2004; 118:277-9; PMID:15294153; http://dx.doi.org/10.1016/j.cell.2004.07.011 (Pubitemid 39061108)
19. Howell GM, Grandis JR. Molecular mediators of metastasis in head and neck squamous cell carcinoma. Head Neck 2005; 27:710-7; PMID:15952195; http://dx.doi.org/10.1002/hed.20222 (Pubitemid 41113773)
20. Leemans CR, Tiwari R, Nauta JJP, van der Waal I, Snow GB. Recurrence at the primary site in head and neck cancer and the significance of neck lymph node metastases as a prognostic factor. Cancer 1994; 73:187-90; PMID:8275423; http://dx.doi.org/10.1002/1097-0142(19940101)73:1<187::AIDCNCR2820730132> 3.0.CO;2-J (Pubitemid 24012742)
21. Chua HH, Yeh TH, Wang YP, Huang YT, Sheen TS, Lo YC, Chou YC, Tsai CH. Upregulation of discoidin domain receptor 2 in nasopharyngeal carcinoma. Head Neck 2008; 30:427-36; PMID:18023033; http://dx.doi.org/10.1002/hed.20724
22. Luo R, Zhong B, Zong Y, Liang X, Wu Q, Lin S, He J, Liang Y, Li Z. The Constitutional Feature of Histopathological Types in Nasopharyngeal Carcinoma in High-incidence Area. Bulletin of Chinese Cancer 2001; 2001:473-5
23. Kawai I, Hisaki T, Sugiura K, Naito K, Kano K. Discoidin domain receptor 2 (DDR2) regulates proliferation of endochondral cells in mice. Biochem Biophys Res Commun 2012; 427:611-7; PMID:23022180; http://dx.doi.org/10.1016/j.bbrc. 2012.09.106
24. Olaso E, Ikeda K, Eng FJ, Xu L, Wang LH, Lin HC, Friedman SL. DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells. J Clin Invest 2001; 108:1369-78; PMID:11696582; http://dx.doi.org/10. 1172/JCI200112373 (Pubitemid 33107765)
25. Labrador JP, Azcoitia V, Tuckermann J, Lin C, Olaso E, Mañes S, Brückner K, Goergen JL, Lemke G, Yancopoulos G, et al. The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep 2001; 2:446-52; PMID:11375938; http://dx.doi.org/10.1093/embo-reports/ kve094 (Pubitemid 32519565)
26. Olaso E, Labrador JP, Wang L, Ikeda K, Eng FJ, Klein R, Lovett DH, Lin HC, Friedman SL. Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2. J Biol Chem 2002; 277:3606-13; PMID:11723120; http://dx.doi.org/10.1074/jbc. M107571200 (Pubitemid 34953233)
27. Hou G, Wang D, Bendeck MP. Deletion of discoidin domain receptor 2 does not affect smooth muscle cell adhesion, migration, or proliferation in response to type I collagen. Cardiovasc Pathol 2012; 21:214-8; PMID:21865059; http://dx.doi.org/10.1016/j.carpath.2011.07.006
28. Kawata R, Shimada T, Maruyama S, Hisa Y, Takenaka H, Murakami Y. Enhanced production of matrix metalloproteinase-2 in human head and neck carcinomas is correlated with lymph node metastasis. Acta Otolaryngol 2002; 122:101-6; PMID:11876588; http://dx.doi.org/10.1080/00016480252775823 (Pubitemid 34171369)
29. Kurahara S, Shinohara M, Ikebe T, Nakamura S, Beppu M, Hiraki A, Takeuchi H, Shirasuna K. Expression of MMPS, MT-MMP, and TIMPs in squamous cell carcinoma of the oral cavity: correlations with tumor invasion and metastasis. Head Neck 1999; 21:627-38; PMID:10487950; http://dx.doi.org/10.1002/(SICI)1097- 0347(199910)21:7<627::AID-HED7>3.0.CO;2-2 (Pubitemid 29459868)
30. O-Charoenrat P, Rhys-Evans PH, Eccles SA. Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 2001; 127:813-20; PMID:11448356 (Pubitemid 32619361)
31. Radhakrishnan R, Shrestha B, Bajracharya D. P31. Expression of matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 in oral squamous cell carcinomas. Oral Oncol 2011; 47:S84; http://dx.doi.org/10.1016/j. oraloncology.2011.06.274
32. Fidler IJ. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003; 3:453-8; PMID:12778135; http://dx.doi.org/10.1038/nrc1098 (Pubitemid 37328849)
33. Gupta GP, Massagué J. Cancer metastasis: building a framework. Cell 2006; 127:679-95; PMID:17110329; http://dx.doi.org/10.1016/j.cell.2006.11. 001 (Pubitemid 44781029)
34. Yilmaz M, Christofori G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev 2009; 28:15-33; PMID:19169796; http://dx.doi.org/10.1007/ s10555-008-9169-0
35. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID:21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013
36. Thiery JP, Acloque H, Huang RYJ, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139:871-90; PMID:19945376; http://dx.doi.org/10.1016/j.cell.2009.11.007
37. Sobin LH, Gospodarowicz MK, Wittekind C, eds. TNM classification of malignant tumours. Wiley. com, 2011.