Three-day combination treatment for vulvovaginal candidosis with 200 mg clotrimazol vaginal suppositories and clotrimazol cream for the vulva is significantly better than treatment with vaginal suppositories alone - An earlier, multi-centre, placebo-controlled double blind study

Geburtshilfe und Frauenheilkunde

Volumn 74, Issue 4, 2014, Pages 355-360

  Mendling, W ^a   Schlegelmilch, R ^b  

^a Deutsches Zentrum fuer Infektionen in Gynaekologie und Geburtshilfe   (Germany)

^b Dr Kade Pharmazeutische Fabrik GmbH   (Germany)

Author keywords

clotrimazol cream; clotrimazol vaginal suppositories; combination treatment; vaginal candidosis

Indexed keywords

CLOTRIMAZOLE; PLACEBO;

ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CREAM; DOUBLE BLIND PROCEDURE; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG TOLERANCE; FEMALE; FUNGUS CULTURE; HUMAN; INTRAVAGINAL DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MULTICENTER STUDY; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; SKIN REDNESS; VAGINA CANDIDIASIS; VAGINAL BURNING SENSATION; VAGINAL PRURITUS;

EID: 84899829548     PISSN: 00165751     EISSN: 14388804     Source Type: Journal    
DOI: 10.1055/s-0034-1368243     Document Type: Article

References (15)

1. Beikert F. C., Le M. T., Koeninger A. et al. Recurrent vulvovaginal candidosis: focus on the vulva. Mycoses: 2011; 54 e807 e810
2. Brasch J., Cornely O., Effendy I. et al. Leitlinie Die Vulvovaginalkandidose. AWMF 015/072. 2014. Online: http://www.awmf.org/uploads/ tx-szleitlinien/015-072l-S2k-vulvovaginalkandidose-2013-12.pdf
3. Ferris D. G., Nyirjesy P., Sobel J. D. et al. Over-the-counter antifungal drug misuse associated with patient-diagnosed vulvovaginal candidiasis. Obstet Gynecol: 2002; 99 419 425
4. Mendling W. Die Vulvovaginalkandidose. Der Frauenarzt: 1992; 33 195 196
5. Mendling W. Vaginose, Vaginitis, Zervizitis und Salpingitis. Heidelberg Springer: 2006
6. Mendling W. Burning vulva, Vulvodynie, vulväres Vestibulitis- Syndrom. Frauenarzt: 2008; 49 314 317
7. Mendling W., Birkner V. Die Vakzination mit inaktivierten Laktobazillen oder Heliotherapie kann die Lebensqualität von Frauen mit chronisch rezidivierender vulvovaginaler Kandidose verbessern - Eine prospektive, 3-armige randomisierte Studie. Geburtsh Frauenheilk: 2011; 71 767 772
8. Mendling W. Brasch J; German Society for Gynecology and Obstetrics; Working Group for Infections and Infectimmunology in Gynecology and Obstetrics; German Society of Dermatology the Board of German Dermatologists German Speaking Mycological Society Guideline vulvovaginal candidosis (2010) of the German Society for Gynecology and Obstetrics, the Working Group for Infections and Infectimmunology in Gynecology and Obstetrics, the German Society of Dermatology, the Board of German Dermatologists and the German Speaking Mycological Society. Mycoses: 2012; 55 03 1 13
9. Mendling W., Krauss C., Fladung B. A clinical multicenter study comparing efficacy and tolerability of topical combination therapy with clotrimazole (Canesten, two formats) with oral single dose fluconazole (Diflucan) in vulvovaginal mycoses. Mycoses: 2004; 47 136 142
10. Workowski K. A., Berman S. Centers for Disease Control and Prevention (CDC) Sexually transmitted disease treatment guidelines, 2010. MMWR Recomm Rep: 2010; 59 RR-12 1 110
11. Mohr P. Clotrimazol in der Selbstmedikation bei Vaginalmykosen. Dtsch Apoth: 1994; 46 2 6
12. Nurbhai M., Grimshaw J., Watson M. et al. Oral versus vaginal imidazole and triazole anti-fungal treatment of uncomplicated vulvovaginal candidiasis (Thrush). Cochrane Database Syst Rev: 2007; 4 CD002845
13. Pschyrembel W. Klinisches Wörterbuch. 264. Auflage. Berlin Walter de Gruyter GmbH: 2012
14. Quereux C., Gelas B., Chevallier T. et al. [Evaluation of the efficacy and speed of action of sertaconazole nitrate suppository and cream combined treatment for vulvovaginal candidiasis]. Gynecol Obstet Fertil: 2000; 28 238 244 (Artikel in französischer Sprache)
15. Sobel J., Brooker D., Stein G. E. et al. Single oral dose fluconazole topical therapy of Candida vaginitis. Am J Obstet Gynecol: 1995; 172 1263 1268