Histological healing favors lower risk of colon carcinoma in extensive ulcerative colitis

World Journal of Gastroenterology

Volumn 20, Issue 17, 2014, Pages 4980-4986

  Korelitz, Burton I ^a   Sultan, Keith ^b   Kothari, Megha ^a   Arapos, Leo ^c   Schneider, Judy ^a   Panagopoulos, Georgia ^a  

^a LENOX HILL HOSPITAL   (United States)

^b NORTH SHORE HOSPITAL   (United States)

^c North Oaks Medical Center   (United States)

Author keywords

Colon cancer; High grade dysplasia; Histological inflammation; Risk; Ulcerative colitis

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CHILD; COHORT ANALYSIS; COLON CARCINOMA; COLONOSCOPY; COMPARATIVE STUDY; DESCRIPTIVE RESEARCH; DISEASE ACTIVITY; DYSPLASIA; ENDOSCOPIC MUCOSAL HEALING; FEMALE; HEALING; HISTOLOGY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PRESCHOOL CHILD; RISK; SCHOOL CHILD; ULCERATIVE COLITIS; BIOPSY; COLITIS, ULCERATIVE; COLON; COLONIC NEOPLASMS; COMPLICATION; DISEASE COURSE; MIDDLE AGED; PATHOLOGY; PREDICTIVE VALUE; RETROSPECTIVE STUDY; RISK FACTOR; TIME; TREATMENT OUTCOME; UNITED STATES; WOUND HEALING; YOUNG ADULT;

ADOLESCENT; ADULT; BIOPSY; CHILD; COLITIS, ULCERATIVE; COLON; COLONIC NEOPLASMS; COLONOSCOPY; DISEASE PROGRESSION; FEMALE; HUMANS; MALE; MIDDLE AGED; NEW YORK CITY; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME; WOUND HEALING; YOUNG ADULT;

EID: 84899824674     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i17.4980     Document Type: Article

References (40)

1. Eaden JA, Abrams KR, Mayberry JF. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut 2001; 48: 526-535 [PMID: 11247898]
2. Rutter MD, Saunders BP, Wilkinson KH, Rumbles S, Schofield G, Kamm MA, Williams CB, Price AB, Talbot IC, Forbes A. Cancer surveillance in longstanding ulcerative colitis: endoscopic appearances help predict cancer risk. Gut 2004; 53: 1813-1816 [PMID: 15542520]
3. Kornbluth A, Sachar DB. Ulcerative colitis practice guidelines in adults: American College Of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol 2010; 105: 501-523; quiz 524 [PMID: 20068560 DOI: 10.1038/ajg.2009.727]
4. Greenstein AJ, Sachar DB, Smith H, Pucillo A, Papatestas AE, Kreel I, Geller SA, Janowitz HD, Aufses AH. Cancer in universal and left-sided ulcerative colitis: factors determining risk. Gastroenterology 1979; 77: 290-294 [PMID: 447042]
5. Rutter MD, Saunders BP, Wilkinson KH, Rumbles S, Schofield G, Kamm MA, Williams CB, Price AB, Talbot IC, Forbes A. Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis. Gastroenterology 2006; 130: 1030-1038 [PMID: 16618396]
6. Ekbom A, Helmick C, Zack M, Adami HO. Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med 1990; 323: 1228-1233 [PMID: 2215606]
7. Rutter M, Saunders B, Wilkinson K, Rumbles S, Schofield G, Kamm M, Williams C, Price A, Talbot I, Forbes A. Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. Gastroenterology 2004; 126: 451-459 [PMID: 14762782]
8. Gupta RB, Harpaz N, Itzkowitz S, Hossain S, Matula S, Kornbluth A, Bodian C, Ullman T. Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study. Gastroenterology 2007; 133: 1099-1105; quiz 1340-1341 [PMID: 17919486]
9. Regueiro M, Rodemann J, Kip KE, Saul M, Swoger J, Baidoo L, Schwartz M, Barrie A, Binion D. Physician assessment of ulcerative colitis activity correlates poorly with endoscopic disease activity. Inflamm Bowel Dis 2011; 17: 1008-1014 [PMID: 20812333 DOI: 10.1002/ibd.21445]
10. Rubin DT. Utilizing mucosal healing as a treatment goal in ulcerative colitis. Gastro Hep 2009; 11: 771-773
11. Kane S, Lu F, Kornbluth A, Awais D, Higgins PD. Controversies in mucosal healing in ulcerative colitis. Inflamm Bowel Dis 2009; 15: 796-800 [PMID: 19213060]
12. Schnitzler F, Fidder H, Ferrante M, Noman M, Arijs I, Van Assche G, Hoffman I, Van Steen K, Vermeire S, Rutgeerts P. Mucosal healing predicts long-term outcome of maintenance therapy with infliximab in Crohn's disease. Inflamm Bowel Dis 2009; 15: 1295-1301 [PMID: 19340881 DOI: 10.1002/ ibd.20927]
13. Pineton de Chambrun G, Peyrin-Biroulet L, Lémann M, Colombel JF. Clinical implications of mucosal healing for the management of IBD. Nat Rev Gastroenterol Hepatol 2010; 7: 15-29 [PMID: 19949430 DOI: 10.1038/nrgastro.2009.203]
14. Goldstone R, Itzkowitz S, Harpaz N, Ullman T. Dysplasia is more common in the distal than proximal colon in ulcerative colitis surveillance. Inflamm Bowel Dis 2012; 18: 832-837 [PMID: 21739534 DOI: 10.1002/ibd.21809]
15. Truelove SC, Richards WC. Biopsy studies in ulcerative colitis. Br Med J 1956; 1: 1315-1318 [PMID: 13316140]
16. Dick AP, Grayson MJ. Ulcerative colitis. A follow-up investigation with mucosal biopsy studies. Br Med J 1961; 1: 160-165 [PMID: 13722664]
17. Matts SGF. The Value of rectal Biopsies in the diagnosis of Ulcerative Colitis. Quart J Med 1961; 30: 393-407
18. Morson BC. Rectal biopsy in inflammatory bowel disease. N Engl J Med 1972; 287: 1337-1339 [PMID: 4564312]
19. Dick AP, Holt LP, Dalton ER. Persistence of mucosal abnormality in ulcerative colitis. Gut 1966; 7: 355-360 [PMID: 5917422]
20. Sommers SC, Korelitz BI. Mucosal-cell counts in ulcerative and granulomatous colitis. Am J Clin Pathol 1975; 63: 359-365 [PMID: 234674]
21. Korelitz BI, Sommers SC. Responses to drug therapy in ulcerative colitis. Evaluation by rectal biopsy and histopathological changes. Am J Gastroenterol 1975; 64: 365-370 [PMID: 2008]
22. Riley SA, Mani V, Goodman MJ, Dutt S, Herd ME. Microscopic activity in ulcerative colitis: what does it mean? Gut 1991; 32: 174-178 [PMID: 1864537]
23. Bitton A, Peppercorn MA, Antonioli DA, Niles JL, Shah S, Bousvaros A, Ransil B, Wild G, Cohen A, Edwardes MD, Stevens AC. Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis. Gastroenterology 2001; 120: 13-20 [PMID: 11208709]
24. Bessissow T, Lemmens B, Ferrante M, Bisschops R, Van Steen K, Geboes K, Van Assche G, Vermeire S, Rutgeerts P, De Hertogh G. Prognostic value of serologic and histologic markers on clinical relapse in ulcerative colitis patients with mucosal healing. Am J Gastroenterol 2012; 107: 1684-1692 [PMID: 23147523 DOI: 10.1038/ajg.2012.301]
25. Higgins PD, Schwartz M, Mapili J, Zimmermann EM. Is endoscopy necessary for the measurement of disease activity in ulcerative colitis? Am J Gastroenterol 2005; 100: 355-361 [PMID: 15667493]
26. Dhanda AD, Creed TJ, Greenwood R, Sands BE, Probert CS. Can endoscopy be avoided in the assessment of ulcerative colitis in clinical trials? Inflamm Bowel Dis 2012; 18: 2056-2062 [PMID: 22271464 DOI: 10.1002/ibd.22879]
27. Rutgeerts P, Vermeire S, Van Assche G. Mucosal healing in inflammatory bowel disease: impossible ideal or therapeutic target? Gut 2007; 56: 453-455 [PMID: 17369375]
28. Baars JE, Nuij VJ, Oldenburg B, Kuipers EJ, van der Woude CJ. Majority of patients with inflammatory bowel disease in clinical remission have mucosal inflammation. Inflamm Bowel Dis 2012; 18: 1634-1640 [PMID: 22069022 DOI: 10.1002/ ibd.21925]
29. Mathy C, Schneider K, Chen YY, Varma M, Terdiman JP, Mahadevan U. Gross versus microscopic pancolitis and the occurrence of neoplasia in ulcerative colitis. Inflamm Bowel Dis 2003; 9: 351-355 [PMID: 14671483]
30. Geboes K, Riddell R, Ost A, Jensfelt B, Persson T, Löfberg R. A reproducible grading scale for histological assessment of inflammation in ulcerative colitis. Gut 2000; 47: 404-409 [PMID: 10940279]
31. Korelitz BI. Mucosal healing as an index of colitis activity: back to histological healing for future indices. Inflamm Bowel Dis 2010; 16: 1628-1630 [PMID: 20803700 DOI: 10.1002/ ibd.21268]
32. Satchi M, Korelitz BI, Panagopoulos G, Bratcher J, Yu C, Atallah-Vinograd J, Schneider J. Is treatment with 6-mercaptopurine for colitis associated with the development of colorectal cancer? Inflamm Bowel Dis 2013; 19: 785-788 [PMID: 23392347 DOI: 10.1097/MIB.0b013e318289664c]
33. Beaugerie L, Svrcek M, Seksik P, Bouvier AM, Simon T, Allez M, Brixi H, Gornet JM, Altwegg R, Beau P, Duclos B, Bourreille A, Faivre J, Peyrin-Biroulet L, Fléjou JF, Carrat F. Risk of colorectal high-grade dysplasia and cancer in a prospective observational cohort of patients with inflammatory bowel disease. Gastroenterology 2013; 145: 166-175. e8 [PMID: 23541909]
34. Jess T, Loftus EV, Velayos FS, Harmsen WS, Zinsmeister AR, Smyrk TC, Schleck CD, Tremaine WJ, Melton LJ, Munkholm P, Sandborn WJ. Risk of intestinal cancer in inflammatory bowel disease: a population-based study from olmsted county, Minnesota. Gastroenterology 2006; 130: 1039-1046 [PMID: 16618397]
35. Söderlund S, Brandt L, Lapidus A, Karlén P, Broström O, Löfberg R, Ekbom A, Askling J. Decreasing time-trends of colorectal cancer in a large cohort of patients with inflammatory bowel disease. Gastroenterology 2009; 136: 1561-1567; quiz 1818-1819 [PMID: 19422077]
36. Velayos FS, Terdiman JP, Walsh JM. Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: a systematic review and metaanalysis of observational studies. Am J Gastroenterol 2005; 100: 1345-1353 [PMID: 15929768]
37. Ullman T, Croog V, Harpaz N, Hossain S, Kornbluth A, Bodian C, Itzkowitz S. Progression to colorectal neoplasia in ulcerative colitis: effect of mesalamine. Clin Gastroenterol Hepatol 2008; 6: 1225-1230; quiz 1177 [PMID: 18848502 DOI: 10.1016/j.cgh.2008.05.020]
38. Colombel JF, Rutgeerts P, Reinisch W, Esser D, Wang Y, Lang Y, Marano CW, Strauss R, Oddens BJ, Feagan BG, Hanauer SB, Lichtenstein GR, Present D, Sands BE, Sandborn WJ. Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis. Gastroenterology 2011; 141: 1194-1201 [PMID: 21723220 DOI: 10.1053/j.gastro.2011.06.054]
39. Frøslie KF, Jahnsen J, Moum BA, Vatn MH. Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort. Gastroenterology 2007; 133: 412-422 [PMID: 17681162]
40. Flynn A, Kane S. Mucosal healing in Crohn's disease and ulcerative colitis: what does it tell us? Curr Opin Gastroenterol 2011; 27: 342-345 [PMID: 21378560 DOI: 10.1097/ MOG.0b013e3283455c8f]