The histone acetylase activator pentadecylidenemalonate 1b rescues proliferation and differentiation in the human cardiac mesenchymal cells of type 2 diabetic patients

Diabetes

Volumn 63, Issue 6, 2014, Pages 2132-2147

  Vecellio, Matteo ^a,b   Spallotta, Francesco ^a,b   Nanni, Simona ^c   Colussi, Claudia ^c   Cencioni, Chiara ^b   Derlet, Anja ^b   Bassetti, Beatrice ^a   Tilenni, Manuela ^a   Carena, Maria Cristina ^a,b   Farsetti, Antonella ^d   Sbardella, Gianluca ^e   Castellano, Sabrina ^e   Mai, Antonello ^f   Martelli, Fabio ^g   Pompilio, Giulio ^a   Capogrossi, Maurizio C ^h   Rossini, Alessandra ⁱ   Dimmeler, Stefanie ^b   Zeiher, Andreas ^b   Gaetano, Carlo ^b  

^a CENTRO CARDIOLOGICO MONZINO   (Italy)

^b GOETHE UNIVERSITY   (Germany)

^c FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

^d CNR   (Italy)

^e UNIVERSITY OF SALERNO   (Italy)

^f SAPIENZA UNIVERSITY OF ROME   (Italy)

^g IRCCS POLICLINICO SAN DONATO   (Italy)

^h LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

ⁱ UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CELL NUCLEUS ANTIGEN; DNA; ENZYME ACTIVATOR; HISTONE ACETYLTRANSFERASE PCAF; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEMETHYLASE; HISTONE H3; HISTONE H4; ISOPROTEIN; LYSINE; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2; SERINE; SPV 106; UNCLASSIFIED DRUG;

ADULT; AMINO ACID SYNTHESIS; ARTICLE; CARDIAC MESENCHYMAL CELL; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CHROMATIN STRUCTURE; CLINICAL ARTICLE; CONSTITUTIVE HETEROCHROMATIN; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA REPAIR; DOWN REGULATION; EPIGENETICS; GENOMIC INSTABILITY; GROWTH REGULATION; HEART MUSCLE CELL; HISTONE ACETYLATION; HISTONE CODE; HISTONE METHYLATION; HISTONE PHOSPHORYLATION; HUMAN; HUMAN CELL; MESENCHYME CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SENESCENCE; WESTERN BLOTTING;

BLOTTING, WESTERN; CARDIOMYOPATHIES; CELL DIFFERENTIATION; CELL PROLIFERATION; CPG ISLANDS; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; DNA METHYLATION; ENZYME ACTIVATION; FEMALE; HISTONE ACETYLTRANSFERASES; HISTONES; HUMANS; IMMUNOPRECIPITATION; MALE; MALONATES; MESENCHYMAL STROMAL CELLS; MIDDLE AGED; MYOCYTES, CARDIAC; P300-CBP TRANSCRIPTION FACTORS; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC;

EID: 84899824083     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0731     Document Type: Article

References (32)

1. Ershow AG. Environmental influences on development of type 2 diabetes and obesity: challenges in personalizing prevention and management. J Diabetes Sci Tech 2009;3:727-734
2. Mangiapane H. Cardiovascular disease and diabetes. Adv Exp Med Biol 2012;771:219-228
3. Jouven X, Lemaître RN, Rea TD, Sotoodehnia N, Empana JP, Siscovick DS. Diabetes, glucose level, and risk of sudden cardiac death. Eur Heart J 2005;26: 2142-2147
4. Herlitz J, Malmberg K. How to improve the cardiac prognosis for diabetes. Diabetes Care 1999;22(Suppl. 2):B89-B96
5. El-Helou V, Proulx C, Béguin P, et al. The cardiac neural stem cell phenotype is compromised in streptozotocin-induced diabetic cardiomyopathy. J Cell Physiol 2009;220:440-449
6. Fadini GP, Miorin M, Facco M, et al. Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus. J Am Coll Cardiol 2005;45:1449-1457
7. Gallagher KA, Liu ZJ, Xiao M, et al. Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha. J Clin Invest 2007;117:1249-1259
8. Creager MA, Lüscher TF, Cosentino F, Beckman JA. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I. Circulation 2003;108:1527-1532
9. Rossini A, Frati C, Lagrasta C, et al. Human cardiac and bone marrow stromal cells exhibit distinctive properties related to their origin. Cardiovasc Res 2011;89:650-660
10. Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315-317
11. Vecellio M, Meraviglia V, Nanni S, et al. In vitro epigenetic reprogramming of human cardiac mesenchymal stromal cells into functionally competent cardiovascular precursors. PLoS ONE 2012;7:e51694
12. Milite C, Castellano S, Benedetti R, et al. Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs). Bioorg Med Chem 2011;19:3690-3701
13. Spallotta F, Cencioni C, Straino S, et al. Enhancement of lysine acetylation accelerates wound repair. Commun Integr Biol 2013;6:e25466
14. Nanni S, Benvenuti V, Grasselli A, et al. Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer. J Clin Invest 2009;119:1093- 1108
15. Re A, Aiello A, Nanni S, et al. Silencing of GSTP1, a prostate cancer prognostic gene, by the estrogen receptor-b and endothelial nitric oxide synthase complex. Mol Endocrinol 2011;25:2003-2016
16. Lee OK, Kuo TK, Chen WM, Lee KD, Hsieh SL, Chen TH. Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 2004;103: 1669-1675 (Pubitemid 38268958)
17. He JQ, Vu DM, Hunt G, Chugh A, Bhatnagar A, Bolli R. Human cardiac stem cells isolated from atrial appendages stably express c-kit. PLoS ONE 2011;6: e27719
18. Claycomb WC, Lanson NA Jr, Stallworth BS, et al. HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proc Natl Acad Sci U S A 1998;95:2979-2984 (Pubitemid 28135840)
19. Wongtawan T, Taylor JE, Lawson KA, Wilmut I, Pennings S. Histone H4K20me3 and HP1a are late heterochromatin markers in development, but present in undifferentiated embryonic stem cells. J Cell Sci 2011;124:1878- 1890
20. Vetting MW, S de Carvalho LP, Yu M, et al. Structure and functions of the GNAT superfamily of acetyltransferases. Arch Biochem Biophys 2005;433:212- 226 (Pubitemid 39586594)
21. Colussi C, Rosati J, Straino S, et al. Ń-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart. Proc Natl Acad Sci U S A 2011;108:2795-2800
22. El-Osta A, Brasacchio D, Yao D, et al. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med 2008;205:2409-2417
23. Qian W, Miki D, Zhang H, et al. A histone acetyltransferase regulates active DNA demethylation in Arabidopsis. Science 2012;336:1445-1448
24. Bastiaansen AJ, Ewing MM, de Boer HC, et al. Lysine acetyltransferase PCAF is a key regulator of arteriogenesis. Arterioscler Thromb Vasc Biol 2013;33: 1902-1910
25. Hackett JA, Surani MA. DNA methylation dynamics during the mammalian life cycle. Philos Trans R Soc Lond B Biol Sci 2013;368:20110328
26. Ng SF, Lin RC, Laybutt DR, Barres R, Owens JA, Morris MJ. Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring. Nature 2010; 467:963-966
27. Berdasco M, Esteller M. DNA methylation in stem cell renewal and multipotency. Stem Cell Res Ther 2011;2:42
28. Colussi C, Scopece A, Vitale S, et al. P300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(́)-lysine acetylation of contractile proteins. Arterioscler Thromb Vasc Biol 2012;32:2435-2443
29. Wei W, Coelho CM, Li X, et al. p300/CBP-associated factor selectively regulates the extinction of conditioned fear. J Neurosci 2012;32:11930- 11941
30. Ye J. Mechanisms of insulin resistance in obesity. Front Med 2013;7: 14-24
31. Cervoni N, Detich N, Seo SB, Chakravarti D, Szyf M. The oncoprotein Set/ TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing. J Biol Chem 2002;277:25026-25031 (Pubitemid 34951806)
32. Cervoni N, Szyf M. Demethylase activity is directed by histone acetylation. J Biol Chem 2001;276:40778-40787