메뉴 건너뛰기




Volumn 88, Issue 11, 2014, Pages 6318-6328

NTPDASE4 gene products cooperate with the adenovirus E4orf4 Protein through PP2A-dependent and -independent mechanisms and contribute to induction of cell death

Author keywords

[No Author keywords available]

Indexed keywords

APYRASE; E4ORF4 VIRUS PROTEIN; GOLGI UDPASE; MICROORGANISM PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN LALP70; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

EID: 84899812991     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00381-14     Document Type: Article
Times cited : (8)

References (42)
  • 1
    • 52649120879 scopus 로고    scopus 로고
    • Adenovirus E4orf4 protein downregulates MYC expression through interaction with the PP2A-B55 subunit
    • Ben-Israel H, Sharf R, Rechavi G, Kleinberger T. 2008. Adenovirus E4orf4 protein downregulates MYC expression through interaction with the PP2A-B55 subunit. J. Virol. 82:9381-9388. http://dx. doi. org/10. 1128/JVI. 00791-08.
    • (2008) J. Virol. , vol.82 , pp. 9381-9388
    • Ben-Israel, H.1    Sharf, R.2    Rechavi, G.3    Kleinberger, T.4
  • 2
    • 0029940998 scopus 로고    scopus 로고
    • Adenovirus E4 open reading 4 protein autoregulates E4 transcription by inhibiting E1A transactivation of the E4 promoter
    • Bondesson M, Ohman K, Mannervik M, Fan S, Akusjarvi G. 1996. Adenovirus E4 open reading 4 protein autoregulates E4 transcription by inhibiting E1A transactivation of the E4 promoter. J. Virol. 70:3844-3851.
    • (1996) J. Virol. , vol.70 , pp. 3844-3851
    • Bondesson, M.1    Ohman, K.2    Mannervik, M.3    Fan, S.4    Akusjarvi, G.5
  • 3
  • 5
    • 0033541370 scopus 로고    scopus 로고
    • Adenovirus E4 open reading frame 4-induced dephosphorylation inhibits E1A activation of the E2 promoter and E2F-1-mediated transactivation independently of the retinoblastoma tumor suppressor protein
    • Mannervik M, Fan S, Strom AC, Helin K, Akusjarvi G. 1999. Adenovirus E4 open reading frame 4-induced dephosphorylation inhibits E1A activation of the E2 promoter and E2F-1-mediated transactivation independently of the retinoblastoma tumor suppressor protein. Virology 256: 313-321. http://dx. doi. org/10. 1006/viro. 1999. 9663.
    • (1999) Virology , vol.256 , pp. 313-321
    • Mannervik, M.1    Fan, S.2    Strom, A.C.3    Helin, K.4    Akusjarvi, G.5
  • 6
    • 0026669557 scopus 로고
    • Adenovirus E4orf4 protein reduces phosphorylation of c-fos and E1A proteins while simultaneously reducing the level of AP-1
    • Muller U, Kleinberger T, Shenk T. 1992. Adenovirus E4orf4 protein reduces phosphorylation of c-fos and E1A proteins while simultaneously reducing the level of AP-1. J. Virol. 66:5867-5878.
    • (1992) J. Virol. , vol.66 , pp. 5867-5878
    • Muller, U.1    Kleinberger, T.2    Shenk, T.3
  • 7
    • 17144403770 scopus 로고    scopus 로고
    • Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication
    • O'Shea C, Klupsch K, Choi S, Bagus B, Soria C, Shen J, McCormick F, Stokoe D. 2005. Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. EMBO J. 24:1211-1221. http://dx. doi. org/10. 1038/sj. emboj. 7600597.
    • (2005) EMBO J. , vol.24 , pp. 1211-1221
    • O'Shea, C.1    Klupsch, K.2    Choi, S.3    Bagus, B.4    Soria, C.5    Shen, J.6    McCormick, F.7    Stokoe, D.8
  • 8
    • 0033621057 scopus 로고    scopus 로고
    • Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A
    • Shtrichman R, Sharf R, Barr H, Dobner T, Kleinberger T. 1999. Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A. Proc. Natl. Acad. Sci. USA. 96:10080-10085. http://dx. doi. org/10. 1073/pnas. 96. 18. 10080.
    • (1999) Proc. Natl. Acad. Sci. USA. , vol.96 , pp. 10080-10085
    • Shtrichman, R.1    Sharf, R.2    Barr, H.3    Dobner, T.4    Kleinberger, T.5
  • 9
    • 0035049981 scopus 로고    scopus 로고
    • Selection of apoptosis-deficient adenovirus E4orf4 mutants in Saccharomyces cerevisiae
    • Afifi R, Sharf R, Shtrichman R, Kleinberger T. 2001. Selection of apoptosis-deficient adenovirus E4orf4 mutants in Saccharomyces cerevisiae. J. Virol. 75:4444-4447. http://dx. doi. org/10. 1128/JVI. 75. 9. 4444-4447. 2001.
    • (2001) J. Virol. , vol.75 , pp. 4444-4447
    • Afifi, R.1    Sharf, R.2    Shtrichman, R.3    Kleinberger, T.4
  • 10
    • 0035939670 scopus 로고    scopus 로고
    • Adenovirus E4orf4 protein induces PP2A-dependent growth arrest in S. cerevisiae and interacts with the anaphase promoting complex/cyclosome
    • Kornitzer D, Sharf R, Kleinberger T. 2001. Adenovirus E4orf4 protein induces PP2A-dependent growth arrest in S. cerevisiae and interacts with the anaphase promoting complex/cyclosome. J. Cell Biol. 154:331-344. http://dx. doi. org/10. 1083/jcb. 200104104.
    • (2001) J. Cell Biol. , vol.154 , pp. 331-344
    • Kornitzer, D.1    Sharf, R.2    Kleinberger, T.3
  • 11
    • 29244445488 scopus 로고    scopus 로고
    • YND1 interacts with CDC55 and is a novel mediator of E4orf4-induced toxicity
    • Maoz T, Koren R, Ben-Ari I, Kleinberger T. 2005. YND1 interacts with CDC55 and is a novel mediator of E4orf4-induced toxicity. J. Biol. Chem. 280:41270-41277. http://dx. doi. org/10. 1074/jbc. M507281200.
    • (2005) J. Biol. Chem. , vol.280 , pp. 41270-41277
    • Maoz, T.1    Koren, R.2    Ben-Ari, I.3    Kleinberger, T.4
  • 12
    • 0035974917 scopus 로고    scopus 로고
    • Toxicity of human adenovirus E4orf4 protein in Saccharomyces cerevisiae results from interactions with the Cdc55 regulatory B subunit of PP2A
    • Roopchand DE, Lee JM, Shahinian S, Paquette D, Bussey H, Branton PE. 2001. Toxicity of human adenovirus E4orf4 protein in Saccharomyces cerevisiae results from interactions with the Cdc55 regulatory B subunit of PP2A. Oncogene 20:5279-5290. http://dx. doi. org/10. 1038/sj. onc. 1204693.
    • (2001) Oncogene , vol.20 , pp. 5279-5290
    • Roopchand, D.E.1    Lee, J.M.2    Shahinian, S.3    Paquette, D.4    Bussey, H.5    Branton, P.E.6
  • 13
    • 84877346088 scopus 로고    scopus 로고
    • E4orf4 induces PP2A-and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways
    • Pechkovsky A, Lahav M, Bitman E, Salzberg A, Kleinberger T. 2013. E4orf4 induces PP2A-and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways. Proc. Natl. Acad. Sci. USA. 110:E1724-1733. http://dx. doi. org/10. 1073/pnas. 1220282110.
    • (2013) Proc. Natl. Acad. Sci. USA. , vol.110
    • Pechkovsky, A.1    Lahav, M.2    Bitman, E.3    Salzberg, A.4    Kleinberger, T.5
  • 14
    • 84881514081 scopus 로고    scopus 로고
    • The adenovirus E4orf4 protein induces a unique mode of cell death while inhibiting classical apoptosis
    • Pechkovsky A, Salzberg A, Kleinberger T. 2013. The adenovirus E4orf4 protein induces a unique mode of cell death while inhibiting classical apoptosis. Cell Cycle 12:2343-2344. http://dx. doi. org/10. 4161/cc. 25707.
    • (2013) Cell Cycle , vol.12 , pp. 2343-2344
    • Pechkovsky, A.1    Salzberg, A.2    Kleinberger, T.3
  • 15
    • 80055065826 scopus 로고    scopus 로고
    • The adenovirus E4orf4 protein targets PP2A to the ACF chromatin-remodeling factor and induces cell death through regulation of SNF2h-containing complexes
    • Brestovitsky A, Sharf R, Mittelman K, Kleinberger T. 2011. The adenovirus E4orf4 protein targets PP2A to the ACF chromatin-remodeling factor and induces cell death through regulation of SNF2h-containing complexes. Nucleic Acids Res. 39:6414-6427. http://dx. doi. org/10. 1093/nar/gkr231.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 6414-6427
    • Brestovitsky, A.1    Sharf, R.2    Mittelman, K.3    Kleinberger, T.4
  • 16
    • 0027360098 scopus 로고
    • Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription
    • Kleinberger T, Shenk T. 1993. Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription. J. Virol. 67:7556-7560.
    • (1993) J. Virol. , vol.67 , pp. 7556-7560
    • Kleinberger, T.1    Shenk, T.2
  • 17
    • 0034605093 scopus 로고    scopus 로고
    • Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases
    • Lavoie JN, Champagne C, Gingras M-C, Robert A. 2000. Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases. J. Cell Biol. 150:1037-1055. http://dx. doi. org/10. 1083/jcb. 150. 5. 1037.
    • (2000) J. Cell Biol. , vol.150 , pp. 1037-1055
    • Lavoie, J.N.1    Champagne, C.2    Gingras, M.-C.3    Robert, A.4
  • 18
    • 0034601367 scopus 로고    scopus 로고
    • Adenovirus E4orf4 protein interacts with both Bα and B' subunits of protein phosphatase 2A, but E4orf4-induced apoptosis is mediated only by the interaction with Bα
    • Shtrichman R, Sharf R, Kleinberger T. 2000. Adenovirus E4orf4 protein interacts with both Bα and B' subunits of protein phosphatase 2A, but E4orf4-induced apoptosis is mediated only by the interaction with Bα. Oncogene 19:3757-3765. http://dx. doi. org/10. 1038/sj. onc. 1203705.
    • (2000) Oncogene , vol.19 , pp. 3757-3765
    • Shtrichman, R.1    Sharf, R.2    Kleinberger, T.3
  • 19
    • 0033881446 scopus 로고    scopus 로고
    • Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Balpha subunit of protein phosphatase 2A
    • Marcellus RC, Chan H, Paquette D, Thirlwell S, Boivin D, Branton PE. 2000. Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Balpha subunit of protein phosphatase 2A. J. Virol. 74:7869-7877. http://dx. doi. org/10. 1128/JVI. 74. 17. 7869-7877. 2000.
    • (2000) J. Virol. , vol.74 , pp. 7869-7877
    • Marcellus, R.C.1    Chan, H.2    Paquette, D.3    Thirlwell, S.4    Boivin, D.5    Branton, P.E.6
  • 20
    • 58049186804 scopus 로고    scopus 로고
    • Protein phosphatase 2A regulatory subunits and cancer
    • Eichhorn PJ, Creyghton MP, Bernards R. 2009. Protein phosphatase 2A regulatory subunits and cancer. Biochim. Biophys. Acta 1795:1-15. http://dx. doi. org/10. 1016/j. bbcan. 2008. 05. 005.
    • (2009) Biochim. Biophys. Acta , vol.1795 , pp. 1-15
    • Eichhorn, P.J.1    Creyghton, M.P.2    Bernards, R.3
  • 21
    • 4344583853 scopus 로고    scopus 로고
    • Induction of transformed cell-specific apoptosis by the adenovirus E4orf4 protein
    • Kleinberger T. 2004. Induction of transformed cell-specific apoptosis by the adenovirus E4orf4 protein. Prog. Mol. Subcell. Biol. 36:245-267. http://dx. doi. org/10. 1007/978-3-540-74264-7_12.
    • (2004) Prog. Mol. Subcell. Biol. , vol.36 , pp. 245-267
    • Kleinberger, T.1
  • 22
    • 84888273963 scopus 로고    scopus 로고
    • Identification of the adenovirus E4orf4 protein binding site on the B55alpha and Cdc55 regulatory subunits of PP2A: implications for PP2A function, tumor cell killing and viral replication
    • Mui MZ, Kucharski M, Miron MJ, Hur WS, Berghuis AM, Blanchette P, Branton PE. 2013. Identification of the adenovirus E4orf4 protein binding site on the B55alpha and Cdc55 regulatory subunits of PP2A: implications for PP2A function, tumor cell killing and viral replication. PLoS Pathog. 9:e1003742. http://dx. doi. org/10. 1371/journal. ppat. 1003742.
    • (2013) PLoS Pathog. , vol.9
    • Mui, M.Z.1    Kucharski, M.2    Miron, M.J.3    Hur, W.S.4    Berghuis, A.M.5    Blanchette, P.6    Branton, P.E.7
  • 24
    • 2942556519 scopus 로고    scopus 로고
    • Activation of adenovirus type 2 early region 4 ORF4 cytoplasmic death function by direct binding to Src kinase domain
    • Champagne C, Landry MC, Gingras MC, Lavoie JN. 2004. Activation of adenovirus type 2 early region 4 ORF4 cytoplasmic death function by direct binding to Src kinase domain. J. Biol. Chem. 279:25905-25915. http://dx. doi. org/10. 1074/jbc. M400933200.
    • (2004) J. Biol. Chem. , vol.279 , pp. 25905-25915
    • Champagne, C.1    Landry, M.C.2    Gingras, M.C.3    Lavoie, J.N.4
  • 25
    • 70350244450 scopus 로고    scopus 로고
    • Regulation of cell death by recycling endosomes and golgi membrane dynamics via a pathway involving Src-family kinases, Cdc42 and Rab11a
    • Landry MC, Sicotte A, Champagne C, Lavoie JN. 2009. Regulation of cell death by recycling endosomes and golgi membrane dynamics via a pathway involving Src-family kinases, Cdc42 and Rab11a. Mol. Biol. Cell 20: 4091-4106. http://dx. doi. org/10. 1091/mbc. E09-01-0057.
    • (2009) Mol. Biol. Cell , vol.20 , pp. 4091-4106
    • Landry, M.C.1    Sicotte, A.2    Champagne, C.3    Lavoie, J.N.4
  • 26
    • 33745625096 scopus 로고    scopus 로고
    • Adenovirus E4orf4 hijacks rho GTPase-dependent actin dynamics to kill cells: a role for endosome-associated actin assembly
    • Robert A, Smadja-Lamere N, Landry MC, Champagne C, Petrie R, Lamarche-Vane N, Hosoya H, Lavoie JN. 2006. Adenovirus E4orf4 hijacks rho GTPase-dependent actin dynamics to kill cells: a role for endosome-associated actin assembly. Mol. Biol. Cell 17:3329-3344. http://dx. doi. org/10. 1091/mbc. E05-12-1146.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 3329-3344
    • Robert, A.1    Smadja-Lamere, N.2    Landry, M.C.3    Champagne, C.4    Petrie, R.5    Lamarche-Vane, N.6    Hosoya, H.7    Lavoie, J.N.8
  • 27
    • 0032722058 scopus 로고    scopus 로고
    • A yeast Golgi E-type ATPase with an unusual membrane topology
    • Zhong X, Guidotti G. 1999. A yeast Golgi E-type ATPase with an unusual membrane topology. J. Biol. Chem. 274:32704-32711. http://dx. doi. org/10. 1074/jbc. 274. 46. 32704.
    • (1999) J. Biol. Chem. , vol.274 , pp. 32704-32711
    • Zhong, X.1    Guidotti, G.2
  • 28
    • 0035033156 scopus 로고    scopus 로고
    • Ectonucleotidases: some recent developments and a note on nomenclature
    • Zimmermann H. 2001. Ectonucleotidases: some recent developments and a note on nomenclature. Drug Dev. Res. 52:44-56. http://dx. doi. org/10. 1002/ddr. 1097.
    • (2001) Drug Dev. Res. , vol.52 , pp. 44-56
    • Zimmermann, H.1
  • 29
    • 78649496878 scopus 로고    scopus 로고
    • The cytosolic tail of the Golgi apyrase Ynd1 mediates E4orf4-induced toxicity in Saccharomyces cerevisiae
    • Mittelman K, Ziv K, Maoz T, Kleinberger T. 2010. The cytosolic tail of the Golgi apyrase Ynd1 mediates E4orf4-induced toxicity in Saccharomyces cerevisiae. PLoS One 5:e15539. http://dx. doi. org/10. 1371/journal. pone. 0015539.
    • (2010) PLoS One , vol.5
    • Mittelman, K.1    Ziv, K.2    Maoz, T.3    Kleinberger, T.4
  • 30
    • 0034705522 scopus 로고    scopus 로고
    • First apyrase splice variants have different enzymatic properties
    • Biederbick A, Kosan C, Kunz J, Elsasser HP, Rose S. 2000. First apyrase splice variants have different enzymatic properties. J. Biol. Chem. 275: 19018-19024. http://dx. doi. org/10. 1074/jbc. M001245200.
    • (2000) J. Biol. Chem. , vol.275 , pp. 19018-19024
    • Biederbick, A.1    Kosan, C.2    Kunz, J.3    Elsasser, H.P.4    Rose, S.5
  • 31
    • 0032802274 scopus 로고    scopus 로고
    • A human intracellular apyraselike protein, LALP70, localizes to lysosomal/autophagic vacuoles
    • Biederbick A, Rose S, Elsasser HP. 1999. A human intracellular apyraselike protein, LALP70, localizes to lysosomal/autophagic vacuoles. J. Cell Sci. 112:2473-2484.
    • (1999) J. Cell Sci. , vol.112 , pp. 2473-2484
    • Biederbick, A.1    Rose, S.2    Elsasser, H.P.3
  • 32
    • 0032079546 scopus 로고    scopus 로고
    • Golgi localization and functional expression of human uridine diphosphatase
    • Wang TF, Guidotti G. 1998. Golgi localization and functional expression of human uridine diphosphatase. J. Biol. Chem. 273:11392-11399. http://dx. doi. org/10. 1074/jbc. 273. 18. 11392.
    • (1998) J. Biol. Chem. , vol.273 , pp. 11392-11399
    • Wang, T.F.1    Guidotti, G.2
  • 33
    • 4544266664 scopus 로고    scopus 로고
    • The VSFASSQQ motif confers calcium sensitivity to the intracellular apyrase LALP70
    • Biederbick A, Rosser R, Storre J, Elsasser HP. 2004. The VSFASSQQ motif confers calcium sensitivity to the intracellular apyrase LALP70. BMC Biochem. 5:8. http://dx. doi. org/10. 1186/1471-2091-5-8.
    • (2004) BMC Biochem. , vol.5 , pp. 8
    • Biederbick, A.1    Rosser, R.2    Storre, J.3    Elsasser, H.P.4
  • 34
    • 0031949940 scopus 로고    scopus 로고
    • Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells
    • Shtrichman R, Kleinberger T. 1998. Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells. J. Virol. 72:2975-2982.
    • (1998) J. Virol. , vol.72 , pp. 2975-2982
    • Shtrichman, R.1    Kleinberger, T.2
  • 35
    • 0025618980 scopus 로고
    • Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes
    • Hinds P, Finlay CA, Quartin RS, Baker SJ, Fearon ER, Vogelstein B, Levine AJ. 1990. Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes. Cell Growth Differ. 1:571-580.
    • (1990) Cell Growth Differ. , vol.1 , pp. 571-580
    • Hinds, P.1    Finlay, C.A.2    Quartin, R.S.3    Baker, S.J.4    Fearon, E.R.5    Vogelstein, B.6    Levine, A.J.7
  • 36
    • 84868293022 scopus 로고    scopus 로고
    • Preparation of cell-lines for conditional knockdown of gene expression and measurement of the knockdown effects on E4orf4-induced cell death
    • Brestovitsky A, Sharf R, Kleinberger T. 2012. Preparation of cell-lines for conditional knockdown of gene expression and measurement of the knockdown effects on E4orf4-induced cell death. J. Vis. Exp. 2012:4442. http://dx. doi. org/10. 3791/4442.
    • (2012) J. Vis. Exp. , vol.2012 , pp. 4442
    • Brestovitsky, A.1    Sharf, R.2    Kleinberger, T.3
  • 37
    • 0032498630 scopus 로고    scopus 로고
    • E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk
    • Lavoie JN, Nguyen M, Marcellus RC, Branton PE, Shore GC. 1998. E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk. J. Cell Biol. 140:637-645. http://dx. doi. org/10. 1083/jcb. 140. 3. 637.
    • (1998) J. Cell Biol. , vol.140 , pp. 637-645
    • Lavoie, J.N.1    Nguyen, M.2    Marcellus, R.C.3    Branton, P.E.4    Shore, G.C.5
  • 38
    • 59649087879 scopus 로고    scopus 로고
    • The adenovirus E4orf4 protein induces growth arrest and mitotic catastrophe in H1299 human lung carcinoma cells
    • Li S, Szymborski A, Miron MJ, Marcellus R, Binda O, Lavoie JN, Branton PE. 2009. The adenovirus E4orf4 protein induces growth arrest and mitotic catastrophe in H1299 human lung carcinoma cells. Oncogene 28:390-400. http://dx. doi. org/10. 1038/onc. 2008. 393.
    • (2009) Oncogene , vol.28 , pp. 390-400
    • Li, S.1    Szymborski, A.2    Miron, M.J.3    Marcellus, R.4    Binda, O.5    Lavoie, J.N.6    Branton, P.E.7
  • 39
    • 0035163836 scopus 로고    scopus 로고
    • Caspase activation by adenovirus E4orf4 protein is cell line-specific and is mediated by the death receptor pathway
    • Livne A, Shtrichman R, Kleinberger T. 2001. Caspase activation by adenovirus E4orf4 protein is cell line-specific and is mediated by the death receptor pathway. J. Virol. 75:789-798. http://dx. doi. org/10. 1128/JVI. 75. 2. 789-798. 2001.
    • (2001) J. Virol. , vol.75 , pp. 789-798
    • Livne, A.1    Shtrichman, R.2    Kleinberger, T.3
  • 40
    • 0036324663 scopus 로고    scopus 로고
    • Distinct cell death pathways triggered by the adenovirus early region 4 ORF 4 protein
    • Robert A, Miron MJ, Champagne C, Gingras MC, Branton PE, Lavoie JN. 2002. Distinct cell death pathways triggered by the adenovirus early region 4 ORF 4 protein. J. Cell Biol. 158:519-528. http://dx. doi. org/10. 1083/jcb. 200201106.
    • (2002) J. Cell Biol. , vol.158 , pp. 519-528
    • Robert, A.1    Miron, M.J.2    Champagne, C.3    Gingras, M.C.4    Branton, P.E.5    Lavoie, J.N.6
  • 42
    • 0031816872 scopus 로고    scopus 로고
    • The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis
    • Marcellus RC, Lavoie JN, Boivin D, Shore GC, Ketner G, Branton PE. 1998. The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis. J. Virol. 72:7144-7153.
    • (1998) J. Virol. , vol.72 , pp. 7144-7153
    • Marcellus, R.C.1    Lavoie, J.N.2    Boivin, D.3    Shore, G.C.4    Ketner, G.5    Branton, P.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.