Mometasone furoate hydrogel for scalp use: In vitro and in vivo evaluation

Pharmaceutical Development and Technology

Volumn 19, Issue 5, 2014, Pages 618-622

  Salgado, Ana ^a   Raposo, Sara ^a   Marto, Joana ^a   Silva, Alexandra N ^a   Simões, Sandra ^a   Ribeiro, Helena M ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

Anti inflammatory activity; Hydroxypropyl methylcellulose gel; Skin permeation

Indexed keywords

2 PROPANOL; HYDROXYPROPYLMETHYLCELLULOSE; MOMETASONE FUROATE; PROPYLENE GLYCOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED DRUG RELEASE; CREAM; DERMATITIS; DRUG DOSAGE FORM; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG PENETRATION; DRUG STABILITY; EVALUATION STUDY; EYEBROW; FEMALE; HUMAN; HUMAN TISSUE; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; LOTION; MICROBIOLOGICAL EXAMINATION; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; SCALP; VISCOSITY;

ADHESIVENESS; ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFLAMMATORY AGENTS; DELAYED-ACTION PREPARATIONS; DERMATITIS; FEMALE; HUMANS; HYDROGEL; METHYLCELLULOSE; MICE; MIDDLE AGED; PREGNADIENEDIOLS; SCALP; SKIN; SKIN ABSORPTION;

EID: 84899807412     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450.2013.819012     Document Type: Article

References (22)

1. Agner T. Compliance among patients with atopic eczema. Acta Derm Venereol 2005;215:s33-s35.
2. Thestrup-Pedersen K. Treatment strategies and compliance for the adult patient with atopic eczema. Acta Derm Venereol 2005;215: s36-s40.
3. Koda M, Young L, Kradjan W, et al. Applied therapeutics: the clinical usage of drugs. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins; 2004:38-39.
4. Marks R, Pongsehirum D, Saylan T. A method for the assay of topical corticosteroids. Br J Dermatol 1973;88:69-74.
5. Hanifin JM, Cooper KD, Ho VC. Guidelines of care for atopic dermatitis, developed in accordance with the American Academy of Dermatology. J Am Acad Dermatol 2004; 50:391-404.
6. Raposo SC, Simões SD, Almeida AJ, Ribeiro HM. Advanced systems for glucocorticoids dermal delivery. Expert Opin Drug Deliv 2013;10:857-877.
7. Fang JY, Leu YL, Wang YY, Tsai YH. In vitro topical application and in vivo pharmacodynamic evaluation of nonivamide hydrogels using Wistar rat as an animal model. Eur J Pharm Sci 2002;15: 417-423.
8. Tavares R, Salgado S, Raposo S, et al. Emulsões não iónicas como transportadores de glucocorticoides: estudos de cedências e permeação. Revista Portuguesa de Farmácia 2011;LII:139.
9. Valotis A, Neukam K, Elert O, Högger P. Human receptor kinetics, tissue binding affinity, and stability of mometasone furoate. J Pharm Sci 2004;93:1337-1350.
10. Teng XW, Cutler DC, Davies NM. Degradation kinetics of mometasone furoate in aqueous systems. Int J Pharmaceutics 2003;259:129-141.
11. European Pharmacopeia 6.0 - microbiological examination of non sterile products, 2008, 1, 2.6.12.
12. GUIDELINE ICH. Q2 (R1). Validation of analytical procedures, text and methodology. EU: Adopted by CPMP, November 94 Issued as CPMP/ICH/381/95, 2005:2-15.
13. GUIDELINE EMEA. Stability testing: of existing active substances and related finished products. Issued as CPMP/QWP/122/02, 2003:5-13.
14. Farmacopeia Portuguesa 8, Lisboa: INFARMED/Ministério da Saúde e Instituto Nacional da Farmácia e do Medicamento, 157-159.
15. Guidance document for the conduct of skin absorption studies. Paris: Organization for Economic Cooperation and Development; 2004.
16. Young JM, De Young LM. Cutaneous models of inflammation for the evaluation of topical and systemic pharmacological agents. In: Spector J, Back N, Liss AR, eds. Pharmacological methods in the control of inflammation. New York: Alan R. Liss, Inc.; 1989:215-231.
17. Ferrão E, Salgado A, Bronze MR, Ribeiro H. Desenvolvimento e avaliação sensorial de formulações para aplicação no couro cabeludo. Revista Lusófona de Ciências e Tecnologias da Saúde 2007;4:242-250.
18. Magnusson BM, Cross SE, Winckle G, Roberts MS. Determination of in vitro permeability and tissue reservoir characteristics in human skin layers. Skin Pharmacol Physiol 2006;19:336-342.
19. Patel RP, Kamani R. Formulation, optimization and evaluation of mometasone furoate gel. J Pharm Res 2009;2:1842-1847.
20. Hadgraft J, Lane M. Skin permeation: the years of enlightenment. Int J Pharm 2005;305:2-12.
21. Vickers CF. Existence of reservoir in the SC. Arch Dermatol 1963; 88:20-23.
22. Abidi A, Ahmad F, Singh SK, Kumar A. Comparison of reservoir effect of topical corticosteroids in an experimental animal model by histamine-induced wheal suppression test. Indian J Pharmacol 2012; 44:722-725.