Molecular epidemiologic and clinical characteristics of influenza B-associated complications among hospitalized patients during an outbreak in Taiwan

International Journal of Infectious Diseases

Volumn 23, Issue , 2014, Pages 94-100

  Chiu, Shu Chun ^a   Lin, Jih Hui ^a   Wang, Hsiao Chi ^a   Wu, Ho Sheng ^a,b   Chang, Hui Wen ^a   Lin, Yung Cheng ^c   Liu, Hsin Fu ^c,d,e,f  

^a CENTER FOR DISEASE CONTROL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN OCEAN UNIVERSITY   (Taiwan)

^d MACKAY MEMORIAL HOSPITAL   (Taiwan)

^e NATIONAL YANG MING UNIVERSITY   (Taiwan)

^f NATIONAL TAIPEI UNIVERSITY OF NURSING AND HEALTH SCIENCES   (Taiwan)

Author keywords

Hospitalized patients; Influenza virus; Influenza associated complications; Molecular epidemiology; Taiwan

Indexed keywords

HEMAGGLUTININ; INFLUENZA VACCINE; ANTIVIRUS AGENT;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AGED; ANTIVIRAL THERAPY; ARTICLE; BRAIN DISEASE; CHILD; COUGHING; DIARRHEA; DISEASE ASSOCIATION; DISEASE SURVEILLANCE; DROWSINESS; DYSPNEA; ENCEPHALITIS; EPIDEMIC; FATALITY; FATIGUE; FEMALE; FEVER; GENETIC ANALYSIS; HOSPITAL INFECTION; HOSPITAL PATIENT; HUMAN; HYPOTENSION; INFANT; INFLUENZA B; INFLUENZA VACCINATION; INTENSIVE CARE UNIT; LOWER RESPIRATORY TRACT INFECTION; MAJOR CLINICAL STUDY; MALE; MOLECULAR EPIDEMIOLOGY; MYALGIA; NAUSEA; NEWBORN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PNEUMONIA; RHINORRHEA; SORE THROAT; TAIWAN; THORAX PAIN; CLASSIFICATION; DNA SEQUENCE; EPIDEMIOLOGY; GENETIC VARIABILITY; GENETICS; HOSPITALIZATION; INCIDENCE; INFLUENZA VIRUS B; INFLUENZA, HUMAN; ISOLATION AND PURIFICATION; MIDDLE AGED; PRESCHOOL CHILD; RISK FACTOR; SEASON; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTIVIRAL AGENTS; CHILD; CHILD, PRESCHOOL; DISEASE OUTBREAKS; FEMALE; GENETIC VARIATION; HOSPITALIZATION; HUMANS; INCIDENCE; INFANT; INFLUENZA B VIRUS; INFLUENZA, HUMAN; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; MOLECULAR EPIDEMIOLOGY; PHYLOGENY; RISK FACTORS; SEASONS; SEQUENCE ANALYSIS, DNA; TAIWAN; YOUNG ADULT;

EID: 84899790981     PISSN: 12019712     EISSN: 18783511     Source Type: Journal    
DOI: 10.1016/j.ijid.2014.02.017     Document Type: Article

References (29)

1. Lin J.H., Chiu S.C., Shaw M.W., Lin Y.C., Lee C.H., Chen H.Y., et al. Characterization of the epidemic influenza B viruses isolated during 2004-2005 season in Taiwan. Virus Res 2007, 124:204-211.
2. Wang C.C., Chen P.Y., Wang J.D., Liu F.C., Huang F.L., Lee C.Y. Clinical and laboratory analysis of influenza B infection in children in Taichung, Taiwan during the 2006-2007 flu season. Pediatr Neonatol 2009, 50:54-58.
3. Chowell G., Bertozzi S.M., Colchero M.A., Lopez-Gatell H., Alpuche-Aranda C., Hernandez M., et al. Severe respiratory disease concurrent with the circulation of H1N1 influenza. N Engl J Med 2009, 361:674-679.
4. Kash J.C., Tumpey T.M., Proll S.C., Carter V., Perwitasari O., Thomas M.J., et al. Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Nature 2006, 443:578-581.
5. Taubenberger J.K., Morens D.M. The pathology of influenza virus infections. Annu Rev Pathol 2008, 3:499-522.
6. Paddock C.D., Liu L., Denison A.M., Bartlett J.H., Holman R.C., Deleon-Carnes M., et al. Myocardial injury and bacterial pneumonia contribute to the pathogenesis of fatal influenza B virus infection. J Infect Dis 2012, 205:895-905.
7. Peltola V., Ziegler T., Ruuskanen O. Influenza A and B virus infections in children. Clin Infect Dis 2003, 36:299-305.
8. Chen R., Holmes E.C. The evolutionary dynamics of human influenza B virus. J Mol Evol 2008, 66:655-663.
9. Lindstrom S.E., Hiromoto Y., Nishimura H., Saito S., Nerome R., Nerome K. Comparative analysis of evolutionary mechanisms of the hemagglutinin and three internal protein genes of influenza B virus: multiple cocirculating lineages and frequent reassortment of the NP M, and NS genes. J Virol 1999, 73:4413-4426.
10. Nobusawa E., Sato K. Comparison of the mutation rates of human influenza A and B viruses. J Virol 2006, 80:3675-3678.
11. Lo Y.C., Chuang J.H., Kuo H.W., Huang W.T., Hsu Y.F., Liu M.T., et al. Surveillance and vaccine effectiveness of an influenza epidemic predominated by vaccine-mismatched influenza B/Yamagata-lineage viruses in Taiwan, 2011-12 season. PLoS One 2013, 8:e58222.
12. Guindon S., Gascuel O. A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol 2003, 52:696-704.
13. Tamura K., Peterson D., Peterson N., Stecher G., Nei M., Kumar S. Mega5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 2011, 28:2731-2739.
14. Schmidt H.A., Strimmer K., Vingron M., von Haeseler A. Tree-puzzle: maximum likelihood phylogenetic analysis using quartets and parallel computing. Bioinformatics 2002, 18:502-504.
15. Kendal A.P., Joseph J.M., Kobayashi G., Nelson D., Reyes C.R., Ross M.R., et al. Laboratory-based surveillance of influenza virus in the United States during the winter of 1977-1978. I. Periods of prevalence of H1N1 and H3N2 influenza A strains, their relative rates of isolation in different age groups, and detection of antigenic variants. Am J Epidemiol 1979, 110:449-461.
16. Kendal A.P., Lee D.T., Parish H.S., Raines D., Noble G.R., Dowdle W.R. Laboratory-based surveillance of influenza virus in the United States during the winter of 1977-1978. II. Isolation of a mixture of A/Victoria- and A/USSR-like viruses from a single person during an epidemic in Wyoming, USA, January 1978. Am J Epidemiol 1979, 110:462-468.
17. Kendal A.P., Schieble J., Cooney M.K., Chin J., Foy H.M., Noble G.R. Co-circulation of two influenza A (H3N2) antigenic variants detected by virus surveillance in individual communities. Am J Epidemiol 1978, 108:308-311.
18. Wiley D.C., Skehel J.J. The structure and function of the hemagglutinin membrane glycoprotein of influenza virus. Annu Rev Biochem 1987, 56:365-394.
19. European Centre for Disease Prevention and Control. Influenza virus characterization. ECDC; Available at: (accessed 24.08.12). http://www.ecdc.europa.eu/en/publications/Publications/CNRL-July-2012.pdf.
20. Dao C.N., Kamimoto L., Nowell M., Reingold A., Gershman K., Meek J., et al. Adult hospitalizations for laboratory-positive influenza during the 2005-2006 through 2007-2008 seasons in the United States. J Infect Dis 2010, 202:881-888.
21. Feng L., Shay D.K., Jiang Y., Zhou H., Chen X., Zheng Y., et al. Influenza-associated mortality in temperate and subtropical Chinese cities, 2003-2008. Bull World Health Organ 2012, 90. 279-88B.
22. Simmerman J.M., Chittaganpitch M., Levy J., Chantra S., Maloney S., Uyeki T., et al. Incidence, seasonality and mortality associated with influenza pneumonia in Thailand: 2005-2008. PLoS One 2009, 4:e7776.
23. Camilloni B., Neri M., Lepri E., Basileo M., Sigismondi N., Puzelli S., et al. An influenza B outbreak during the 2007/2008 winter among appropriately immunized elderly people living in a nursing home. Vaccine 2010, 28:7536-7541.
24. Shaw M.W., Xu X., Li Y., Normand S., Ueki R.T., Kunimoto G.Y., et al. Reappearance and global spread of variants of influenza B/Victoria/2/87 lineage viruses in the 2000-2001 and 2001-2002 seasons. Virology 2002, 303:1-8.
25. World Health Organization. Recommendations for influenza vaccine composition, Northern Hemisphere: 2008-2009. Geneva: WHO; Available at: (accessed 29.02.08). http://www.who.int/influenza/vaccines/vaccinerecommendations1/en/index3.html.
26. Krystal M., Young J.F., Palese P., Wilson I.A., Skehel J.J., Wiley D.C. Sequential mutations in hemagglutinins of influenza B virus isolates: definition of antigenic domains. Proc Natl Acad Sci U S A 1983, 80:4527-4531.
27. Stray S.J., Pittman L.B. Subtype- and antigenic site-specific differences in biophysical influences on evolution of influenza virus hemagglutinin. Virol J 2012, 9:91.
28. Update: influenza activity-United States, 2011-2012 season and composition of the 2012-13 influenza vaccines. Morb Mortal Wkly Rep (MMWR) 2012, 61:414-420. Centers for Disease Control and Prevention.
29. Lin J.H., Chiu S.C., Lin Y.C., Cheng J.C., Wu H.S., Salemi M., et al. Exploring the molecular epidemiology and evolutionary dynamics of influenza A virus in Taiwan. PLoS One 2013, 8:e61957.