Effect of precipitation inhibitors on indomethacin supersaturation maintenance: Mechanisms and modeling

Molecular Pharmaceutics

Volumn 11, Issue 5, 2014, Pages 1489-1499

  Patel, Dhaval D ^a,b   Anderson, Bradley D ^a  

^a University of Kentucky   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

adsorption; crystal growth kinetics; cyclodextrin; HPMC; indomethacin; precipitation inhibitors; PVP; reactive diffusion layer theory; solubility; supersaturation

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; HYDROXYPROPYLMETHYLCELLULOSE; INDOMETACIN; PHARMACEUTICAL VEHICLES AND ADDITIVES; POLYMERIC PRECIPITATION INHIBITOR; POVIDONE; UNCLASSIFIED DRUG; CYCLODEXTRIN;

ADSORPTION; ARTICLE; CHEMICAL PHENOMENA; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTALLIZATION; DIFFUSION; DRUG SOLUBILITY; GROWTH INHIBITION; GROWTH RATE; PRECIPITATION; PRIORITY JOURNAL; SUPERSATURATION; ULTRAVIOLET SPECTROSCOPY; CHEMISTRY; SOLUBILITY;

ADSORPTION; CHEMICAL PRECIPITATION; CRYSTALLIZATION; CYCLODEXTRINS; INDOMETHACIN; SOLUBILITY;

EID: 84899786051     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400658k     Document Type: Article

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