Strained cycloalkynes as new protein sulfenic acid traps

Journal of the American Chemical Society

Volumn 136, Issue 17, 2014, Pages 6167-6170

  Poole, Thomas H ^a   Reisz, Julie A ^b   Zhao, Weiling ^b   Poole, Leslie B ^a,b   Furdui, Cristina M ^a,b   King, S Bruce ^a,b  

^a WAKE FOREST UNIVERSITY   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; COVALENT BONDS; PROBES;

1 ,3-DICARBONYL; CELLULAR REDOX REGULATION; DISULFIDE BONDS; HIGHLY STRAINED; KINETIC COMPETITIONS; REACTIVE OXYGEN SPECIES; SMALL MOLECULES; SULFUR CHEMISTRY;

PROTEINS;

5,5 DIMETHYL 1,3 CYCLOHEXANEDIONE; ALKENYL GROUP; ALKYNE; CYCLOALKYNE; CYSTEINE; DISULFIDE; SULFENIC ACID DERIVATIVE; THIOL; UNCLASSIFIED DRUG; BICYCLO COMPOUND; BICYCLO(6.1.0)NONYNE; CYCLOALKANE DERIVATIVE; CYSTEINESULFENIC ACID; PROTEIN;

ARTICLE; COVALENT BOND; CYTOTOXICITY; NUCLEOPHILICITY; PROTEIN STRUCTURE; ANALOGS AND DERIVATIVES; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; OXIDATION REDUCTION REACTION;

BICYCLO COMPOUNDS; CELL LINE; CYCLOPARAFFINS; CYSTEINE; HUMANS; MODELS, MOLECULAR; OXIDATION-REDUCTION; PROTEINS; SULFENIC ACIDS;

EID: 84899766376     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja500364r     Document Type: Article

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