T-cell immunity in the aging human

Haematologica

Volumn 99, Issue 5, 2014, Pages 795-797

  Pawelec, Graham ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGE; AGING; BONE MARROW; CELLULAR IMMUNITY; CYTOMEGALOVIRUS; EDITORIAL; EPSTEIN BARR VIRUS; HEMATOPOIETIC STEM CELL; HERPES VIRUS; HUMAN; IMMUNE RESPONSE; IMMUNITY; NONHUMAN; PHENOTYPE; RISK FACTOR; SIGNAL TRANSDUCTION; CELL AGING; IMMUNOLOGY; T LYMPHOCYTE;

AGING; CELL AGING; HUMANS; IMMUNITY; T-LYMPHOCYTES;

EID: 84899757905     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2013.094383     Document Type: Editorial

References (15)

1. Müller L, Fülöp T, Pawelec G. Immunosenescence in vertebrates and invertebrates. Immun Ageing. 2013; 10(1): 12.
2. Bertram L, Böckenhoff A, Demuth I, Düzel S, Eckardt R, Li SC, et al. Cohort Profile: The Berlin Aging Study II (BASE-II). Int J Epidemiol. 2013 Mar 14. [Epub ahead of print].
3. Pawelec G, Akbar A, Caruso C, Solana R, Grubeck-Loebenstein B, Wikby A. Human immunosenescence: is it infectious? Immunol Rev. 2005; 205: 257-68.
4. Gruver AL, Hudson LL, Sempowski GD. Immunosenescence of ageing. J Pathol. 2007; 211(2): 144-56.
5. Solana R, Pawelec G, Tarazona R. Aging and innate immunity. Immunity. 2006; 24(5): 491-4.
6. Pawelec G. Hallmarks of human "immunosenescence": adaptation or dysregulation? Immun Ageing. 2012; 9(1): 15.
7. Komatsu H, Inui A, Sogo T, Fujisawa T, Nagasaka H, Nonoyama S, et al. Large scale analysis of pediatric antiviral CD8+ T cell populations reveals sustained, functional and mature responses. Immun Ageing. 2006; 3: 11.
8. van Leeuwen EM, Remmerswaal EB, Vossen MT, Rowshani AT, Wertheim-van Dillen PM, van Lier RA, et al. Emergence of a CD4+CD28-granzyme B+, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection. J Immunol. 2004; 173(3): 1834-41.
9. Ouyang Q, Wagner WM, Walter S, Müller CA, Wikby A, Aubert G, et al. An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness. Mech Ageing Dev. 2003; 124(4): 477-85.
10. Derhovanessian E, Maier AB, Beck R, Jahn G, Hähnel K, Slagboom PE, et al. Hallmark features of immunosenescence are absent in familial longevity. J Immunol. 2010; 185(8): 4618-24.
11. Chidrawar S, Khan N, Wei W, McLarnon A, Smith N, Nayak L, et al. Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals. Clin Exp Immunol. 2009; 155(3): 423-32.
12. Derhovanessian E, Maier AB, Hähnel K, Zelba H, de Craen AJ, Roelofs H, et al. Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people. Age (Dordr). 2013; 35(4): 1387-99.
13. Geiger H, de Haan G, Florian MC. The ageing haematopoietic stem cell compartment. Nat Rev Immunol. 2013; 13(5): 376-89.
14. Tsukamoto H, Clise-Dwyer K, Huston GE, Duso DK, Buck AL, Johnson LL, et al. Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects. Proc Natl Acad Sci USA. 2009; 106(43): 18333-8.
15. Larbi A, Pawelec G, Wong SC, Goldeck D, Tai JJ, Fulop T. Impact of age on T cell signaling: a general defect or specific alterations? Ageing Res Rev. 2011; 10(3): 370-8.