miR-200c Regulates IL8 expression by targeting IKBKB: A potential mediator of inflammation in leiomyoma pathogenesis

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Chuang, Tsai Der ^a,b   Khorram, Omid ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; I KAPPA B ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MICRORNA 200C; SYNAPTOTAGMIN I; I KAPPA B KINASE; IKBKB PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; MICRORNA; MIRN200 MICRORNA, HUMAN; TRANSCRIPTION FACTOR RELA;

3' UNTRANSLATED REGION; ADULT; ARTICLE; CANCER CELL; CELL FRACTIONATION; CELL NUCLEUS TRANSPLANTATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; GAIN OF FUNCTION MUTATION; GENE; GENE EXPRESSION; GENE FUNCTION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; IKBKB:A GENE; IL8 GENE; IMMUNOPATHOGENESIS; INFLAMMATION; LEIOMYOMA; LEIOMYOMA SMOOTH MUSCLE CELL; LOSS OF FUNCTION MUTATION; MYOMETRIUM; PROMOTER REGION; PROTEIN EXPRESSION; RNA ISOLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHOSPHORYLATION;

ADULT; BASE SEQUENCE; CASPASE 3; CASPASE 7; DOWN-REGULATION; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B KINASE; INFLAMMATION; INTERLEUKIN-8; LEIOMYOMA; MICRORNAS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA;

EID: 84899751551     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0095370     Document Type: Article

References (47)

1. Chegini N (2010) Proinflammatory and profibrotic mediators: principal effectors of leiomyoma development as a fibrotic disorder. Semin Reprod Med 28: 180-203.
2. Schafer M, Werner S (2008) Cancer as an overhealing wound: an old hypothesis revisited. Nat Rev Mol Cell Biol 9: 628-638.
3. Wynn TA (2008) Cellular and molecular mechanisms of fibrosis. J Pathol 214: 199-210.
4. Fabian MR, Sonenberg N, Filipowicz W (2010) Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem 79: 351-379.
5. Huntzinger E, Izaurralde E (2011) Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet 12: 99-110.
6. Ma X, Becker Buscaglia LE, Barker JR, Li Y (2011) MicroRNAs in NF-kappaB signaling. J Mol Cell Biol 3: 159-166.
7. Schickel R, Boyerinas B, Park SM, Peter ME (2008) MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death. Oncogene 27: 5959-5974.
8. Elsharkawy AM, Mann DA (2007) Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis. Hepatology 46: 590-597. (Pubitemid 47344795)
9. Julien S, Puig I, Caretti E, Bonaventure J, Nelles L, et al. (2007) Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition. Oncogene 26: 7445-7456. (Pubitemid 350158710)
10. Karin M (2009) NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol 1: a000141.
11. Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, et al. (2004) IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117: 225-237. (Pubitemid 38496242)
12. Khanjani S, Terzidou V, Johnson MR, Bennett PR (2012) NFkappaB and AP-1 drive human myometrial IL8 expression. Mediators Inflamm 2012: 504952.
13. Bhattacharyya S, Balakathiresan NS, Dalgard C, Gutti U, Armistead D, et al. (2011) Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8. J Biol Chem 286: 11604-11615.
14. Bhaumik D, Scott GK, Schokrpur S, Patil CK, Campisi J, et al. (2008) Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells. Oncogene 27: 5643-5647.
15. Chen R, Alvero AB, Silasi DA, Kelly MG, Fest S, et al. (2008) Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells. Oncogene 27: 4712-4723.
16. Fang Y, Shi C, Manduchi E, Civelek M, Davies PF (2010) MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro. Proc Natl Acad Sci U S A 107: 13450-13455.
17. Song L, Huang Q, Chen K, Liu L, Lin C, et al. (2010) miR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-beta. Biochem Biophys Res Commun 402: 135-140.
18. Katoh Y, Katoh M (2008) Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review). Int J Mol Med 22: 271-275.
19. Panda H, Pelakh L, Chuang TD, Luo X, Bukulmez O, et al. (2012) Endometrial miR-200c is altered during transformation into cancerous states and targets the expression of ZEBs, VEGFA, FLT1, IKKbeta, KLF9, and FBLN5. Reprod Sci 19: 786-796.
20. Reddy MA, Jin W, Villeneuve L, Wang M, Lanting L, et al. (2012) Proinflammatory role of microrna-200 in vascular smooth muscle cells from diabetic mice. Arterioscler Thromb Vasc Biol 32: 721-729.
21. Chuang TD, Panda H, Luo X, Chegini N (2012) miR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5. Endocr Relat Cancer 19: 541-556.
22. Stanisavljevic J, Porta-de-la-Riva M, Batlle R, de Herreros AG, Baulida J (2011) The p65 subunit of NF-kappaB and PARP1 assist Snail1 in activating fibronectin transcription. J Cell Sci 124: 4161-4171.
23. Chegini N, Ma C, Tang XM, Williams RS (2002) Effects of GnRH analogues, 'add-back' steroid therapy, antiestrogen and antiprogestins on leiomyoma and myometrial smooth muscle cell growth and transforming growth factor-beta expression. Mol Hum Reprod 8: 1071-1078. (Pubitemid 36032844)
24. Chuang TD, Guh JY, Chiou SJ, Chen HC, Huang JS, et al. (2007) Phosphoinositide 3-kinase is required for high glucose-induced hypertrophy and p21WAF1 expression in LLC-PK1 cells. Kidney Int 71: 867-874.
25. Chuang TD, Luo X, Panda H, Chegini N (2012) miR-93/106b and their host gene, MCM7, are differentially expressed in leiomyomas and functionally target F3 and IL-8. Mol Endocrinol 26: 1028-1042.
26. Yu Z, Willmarth NE, Zhou J, Katiyar S, Wang M, et al. (2010) microRNA 17/ 20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling. Proc Natl Acad Sci U S A 107: 8231-8236.
27. Schmeck B, Zahlten J, Moog K, van Laak V, Huber S, et al. (2004) Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor. J Biol Chem 279: 53241-53247. (Pubitemid 40051827)
28. Solanas G, Porta-de-la-Riva M, Agusti C, Casagolda D, Sanchez-Aguilera F, et al. (2008) E-cadherin controls beta-catenin and NF-kappaB transcriptional activity in mesenchymal gene expression. J Cell Sci 121: 2224-2234.
29. Selam B, Kayisli UA, Garcia-Velasco JA, Akbas GE, Arici A (2002) Regulation of fas ligand expression by IL-8 in human endometrium. J Clin Endocrinol Metab 87: 3921-3927. (Pubitemid 34879549)
30. Fujimoto J, Aoki I, Khatun S, Toyoki H, Tamaya T (2002) Clinical implications of expression of interleukin-8 related to myometrial invasion with angiogenesis in uterine endometrial cancers. Ann Oncol 13: 430-434. (Pubitemid 34705005)
31. Waugh DJ, Wilson C (2008) The interleukin-8 pathway in cancer. Clin Cancer Res 14: 6735-6741.
32. Pecot CV, Rupaimoole R, Yang D, Akbani R, Ivan C, et al. (2013) Tumour angiogenesis regulation by the miR-200 family. Nat Commun 4: 2427.
33. Wang S, Liu Z, Wang L, Zhang X (2009) NF-kappaB signaling pathway, inflammation and colorectal cancer. Cell Mol Immunol 6: 327-334.
34. Delhase M, Hayakawa M, Chen Y, Karin M (1999) Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 284: 309-313. (Pubitemid 129523447)
35. Dai L, Gu L, Di W (2012) MiR-199a attenuates endometrial stromal cell invasiveness through suppression of the IKKbeta/NF-kappaB pathway and reduced interleukin-8 expression. Mol Hum Reprod 18: 136-145.
36. Bhaumik D, Scott GK, Schokrpur S, Patil CK, Orjalo AV, et al. (2009) MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY) 1: 402-411.
37. Malik M, Mendoza M, Payson M, Catherino WH (2009) Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression. Fertil Steril 91: 2177-2184.
38. Senturk LM, Sozen I, Gutierrez L, Arici A (2001) Interleukin 8 production and interleukin 8 receptor expression in human myometrium and leiomyoma. Am J Obstet Gynecol 184: 559-566. (Pubitemid 32234966)
39. Syssoev KA, Kulagina NV, Chukhlovin AB, Morozova EB, Totolian AA (2008) Expression of mRNA for chemokines and chemokine receptors in tissues of the myometrium and uterine leiomyoma. Bull Exp Biol Med 145: 84-89.
40. Traenckner EB, Pahl HL, Henkel T, Schmidt KN, Wilk S, et al. (1995) Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli. Embo j 14: 2876-2883.
41. Gao Z, Chiao P, Zhang X, Zhang X, Lazar MA, et al. (2005) Coactivators and corepressors of NF-kappaB in IkappaB alpha gene promoter. J Biol Chem 280: 21091-21098. (Pubitemid 40805668)
42. Li A, Dubey S, Varney ML, Dave BJ, Singh RK (2003) IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol 170: 3369-3376. (Pubitemid 36302216)
43. Wilson C, Wilson T, Johnston PG, Longley DB, Waugh DJ (2008) Interleukin-8 signaling attenuates TRAIL- and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells. Mol Cancer Ther 7: 2649-2661.
44. Schickel R, Park SM, Murmann AE, Peter ME (2010) miR-200c regulates induction of apoptosis through CD95 by targeting FAP-1. Mol Cell 38: 908-915.
45. Howe EN, Cochrane DR, Richer JK (2011) Targets of miR-200c mediate suppression of cell motility and anoikis resistance. Breast Cancer Res 13: R45.
46. Uhlmann S, Zhang JD, Schwager A, Mannsperger H, Riazalhosseini Y, et al. (2010) miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer. Oncogene 29: 4297-4306.
47. Brandl M, Seidler B, Haller F, Adamski J, Schmid RM, et al. (2010) IKK(alpha) controls canonical TGF(ss)-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells. J Cell Sci 123: 4231-4239.