Human immune responses to H. Pylori HLA class II epitopes identified by immunoinformatic methods

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Zhang, Songhua ^a   Desrosiers, Joseph ^b   Aponte Pieras, Jose R ^a   Dasilva, Kristen ^b   Fast, Loren D ^a,b   Terry, Frances ^c   Martin, William D ^c   De Groot, Anne S ^b,c   Moise , Leonard ^b,c   Moss, Steven F ^a  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY OF RHODE ISLAND   (United States)

^c EpiVax Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HLA ANTIGEN CLASS 2; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; EPITOPE; HLA D ANTIGEN; PEPTIDE;

ADULT; ARTICLE; BACTERIAL GENOME; CD4+ T LYMPHOCYTE; CELL COUNT; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOKINE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; EPITOPE MAPPING; FEMALE; GENETIC CONSERVATION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; TH1 CELL; AMINO ACID SEQUENCE; BIOLOGY; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MIDDLE AGED; MOLECULAR GENETICS; MONONUCLEAR CELL; PHYSIOLOGY; PROCEDURES;

AMINO ACID SEQUENCE; COMPUTATIONAL BIOLOGY; CYTOKINES; ENZYME-LINKED IMMUNOSPOT ASSAY; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; FEMALE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HLA-D ANTIGENS; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERFERON-GAMMA; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PEPTIDES;

EID: 84899741307     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094974     Document Type: Article

References (51)

1. National Institute of Allergy and Infectious Diseases (2013) Emerging and reemerging infectious diseases. Available: http://www.niaid.nih.gov/topics/ emerging/pages/list.aspx Accessed 2013 Nov 14.
2. McColl KE (2010) Clinical practice. Helicobacter pylori infection. N Engl J Med 362: 1597-1604. PMID: 20427808.
3. Parkin DM (2006) The global health burden of infection-associated cancers in the year 2002. Int J Cancer 118: 3030-3044. PMID: 16404738.
4. National Cancer Institute. Stomach (Gastric) Cancer Homepage (2013) Available: http://www.cancer.gov/cancertopics/types/stomach/. Accessed 2013 15 Nov 15.
5. Bray F, Center MM, Ferlay J, Ward E, et al. (2011) Global cancer statistics. CA Cancer J Clin 61: 69-90. PMID:21296855.
6. Atherton JC (2006) The pathogenesis of Helicobacter pylori-induced gastroduodenal diseases. Annu Rev Pathol 1: 63-96. Review. PMID:18039108.
7. Wroblewski LE, Peek RM Jr (2013) Helicobacter pylori in gastric carcinogenesis: mechanisms. Gastroenterol Clin North Am 42: 285-298. PMID:23639641.
8. Islami F, Kamangar F (2008) Helicobacter pylori and esophageal cancer risk: A meta-analysis. Cancer Prev Res (Phila) 1: 329-338. PMCID:PMC3501739.
9. Dellon ES, Peery AF, Shaheen NJ, Morgan DR, Hurrell JM, et al. (2011). Inverse association of esophageal eosinophilia with Helicobacter pylori based on analysis of a US pathology database. Gastroenterology 141: 1586-1592. PMCID:PMC3202656.
10. Chen Y, Blaser MJ (2007) Inverse associations of Helicobacter pylori with asthma and allergy. Arch Intern Med 167: 821-827. PMID:17452546. (Pubitemid 46658341)
11. Reibman J, Marmor M, Filner J, Fernandez-Beros ME, Rogers L, et al. (2008) Asthma is inversely associated with Helicobacter pylori status in an urban population. PLoS One 3: e4060. PMCID:PMC2603593.
12. Luther J, Dave M, Higgins PD, Kao JY (2010) Association between Helicobacter pylori infection and inflammatory bowel disease: A meta-analysis and systematic review of the literature. Inflamm Bowel Dis 16: 1077-1084. PMID:19760778.
13. Oertli M, Müller A (2012) Helicobacter pylori targets dendritic cells to induce immune tolerance, promote persistence and confer protection against allergic asthma. Gut Microbes 3: 566-571. PMCID:PMC3495795.
14. Arnold IC, Dehzad N, Reuter S, Martin H, Becher B, et al. (2011) Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells. J Clin Invest 121: 3088-3093. PMCID:PMC3148731.
15. Ardito M, Fueyo J, Tassone R, Terry F, DaSilva K, et al. (2011) An integrated genomic and immunoinformatic approach to H. pylori vaccine design. Immunome Res 7: 1. PMID: 22130156. Available: http://www.omicsonline.com/open- access/1745-7580/1745-7580-7-049.pdf. Accessed 2013 Dec 15.
16. Wulf M, Hoehn P, Trinder P (2009) Identification and validation of T-cell epitopes using the IFN-c ELISPOT assay. Methods Mol Biol. 524: 439-446. PMID:19377964.
17. Chen L, Li B, Yang WC, He JL, Li NY, et al. (2013) A dominant CD4(+) T-cell response to Helicobacter pylori reduces risk for gastric disease in humans. Gastroenterology 144: 591-600. PMID:23232294.
18. Yang WC, Chen L, Li HB, Li B, Hu J, et al. (2013). Identification of two novel immunodominant UreB CD4(+) T cell epitopes in Helicobacter pylori infected subjects. Vaccine 31: 1204-9. PMID:23306364.
19. Arnold IC, Lee JY, Amieva MR, Roers A, Flavell RA, et al. (2011) Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia. Gastroenterology 140: 199-209. PMID:20600031.
20. Taylor AW (2009) Review of the activation of TGF-beta in immunity. J Leukoc Biol. 85: 29-33. PMID:18818372.
21. Cohen T, Moise L, Ardito M, Martin W, De Groot AS (2010) A method for individualizing the prediction of immunogenicity of protein vaccines and biologic therapeutics: individualized T cell epitope measure (iTEM). J Biomed Biotechnol 2010: 2010. PMID: 20706613. Available: http://www.hindawi.com/ journals/bmri/2010/961752. Accessed 2014 Mar 24.
22. Bogdanos DP, Baum H, Gunsar F, Arioli D, Polymeros D, et al. (2004) Extensive homology between the major immunodominant mitochondrial antigen in primary biliary cirrhosis and Helicobacter pylori does not lead to immunological cross-reactivity. Ma Y, . Burroughs AK, . Vergani D. Scand J Gastroenterol. 39:981-7. PMID:15513338. (Pubitemid 39388463)
23. Hansen BE, Rasmussen AH, Jakobsen BK, Ryder LP, Svejgaard A (2007) Extraordinary cross-reactivity of an autoimmune T-cell receptor recognizing specific peptides both on autologous and on allogeneic HLA class II molecules. Tissue Antigens. 70:42-52. PMID:17559580. (Pubitemid 46890281)
24. Kotloff KL, Sztein MB, Wasserman SS, Losonsky GA, DiLorenzo SC, et al. (2001) Safety and immunogenicity of oral inactivated whole-cell Helicobacter pylori vaccine with adjuvant among volunteers with or without subclinical infection. Infect Immun. 69:3581-90. PMID:11349017. (Pubitemid 32493271)
25. Michetti P, Kreiss C, Kotloff KL, Porta N, Blanco JL, et al. (1999) Oral immunization with urease and Escherichia coli heat-labile enterotoxin is safe and immunogenic in Helicobacter pylori-infected adults. Gastroenterology 116: 804-12. PMID:10092302. (Pubitemid 29153528)
26. Aebischer T, Bumann D, Epple HJ, Metzger W, Schneider T, et al. (2008) Correlation of T cell response and bacterial clearance in human volunteers challenged with Helicobacter pylori revealed by randomized controlled vaccination with Ty21a-based Salmonella vaccines. Gut. 57:1065-72. PMID: 18417532.
27. Sachs G, Weeks DL, Melchers K, Scott DR (2003) The gastric biology of Helicobacter pylori. Annu Rev Physiol. 65: 349-69. PMID:12471160. (Pubitemid 38249158)
28. Malfertheiner P, Schultze V, Rosenkranz B, Kaufmann SH, Ulrichs T, et al. (2008) Safety and immunogenicity of an intramuscular Helicobacter pylori vaccine in noninfected volunteers: A phase I study. Gastroenterology 135: 787-95. PMID:18619971.
29. Tegtmeyer N, Wessler S, Backert S (2011) Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis. FEBS J. 278:1190-202. PMID:21352489.
30. Cendron L, Zanotti G (2011) Structural and functional aspects of unique type IV secretory components in the Helicobacter pylori cag-pathogenicity island. FEBS J. 278:1223-31. PMID:21284804.
31. Fischer W (2011) Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus. FEBS J 278:1203-12. PMID:21352490.
32. Hare S, Fischer W, Williams R, Terradot L, Bayliss R, et al. (2007) Identification, structure and mode of action of a new regulator of the Helicobacter pylori HP0525 ATPase. EMBO J. 26:4926-34. PMID:17972918. (Pubitemid 350191302)
33. Arnold IC, Hitzler I, Müller A (2012) The immunomodulatory properties of Helicobacter pylori confer protection against allergic and chronic inflammatory disorders. Front Cell Infect Microbiol 2: 10. PMCID:PMC3417532.
34. Kao JY, Zhang M, Miller MJ, Mills JC, Wang B, et al. (2010) Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice. Gastroenterology 138: 1046-1054. PMCID:PMC2831148.
35. Harris PR, Wright SW, Serrano C, Riera F, Duarte I, et al. (2008) Helicobacter pylori gastritis in children is associated with a regulatory T-cell response. Gastroenterology 134: 491-499. (Pubitemid 351173044)
36. Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, et al. (2007) Development, cytokine profile and function of human interleukin 17- producing helper T cells. Nat Immunol 8: 950-957. PMID:17676044. (Pubitemid 47300009)
37. Liu H, Rohowsky-Kochan C (2008) Regulation of IL-17 in human CCR6+ effector memory T cells. J Immunol 180: 7948-7957. PMID:18523258.
38. Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F (2007) Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8: 942-949. PMID:17676045. (Pubitemid 47300008)
39. Evans HG, Suddason T, Jackson I, Taams LS, Lord GM (2007) Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes. Proc Natl Acad Sci U S A 104: 17034-17039. PMCID:PMC2040448. (Pubitemid 350210986)
40. Moran AP, Lindner B, Walsh EJ (1997) Structural characterization of the lipid A component of Helicobacter pylori rough- And smooth-form lipopolysaccharides. J Bacteriol 179: 6453-6463. PMCID:PMC179563. (Pubitemid 27443930)
41. Gewirtz AT, Yu Y, Krishna US, Israel DA, Lyons SL, Peek RM Jr (2004) Helicobacter pylori flagellin evades toll-like receptor 5-mediated innate immunity. J Infect Dis 189: 1914-1920. PMID:15122529. (Pubitemid 38657228)
42. Andersen-Nissen E, Smith KD, Strobe KL, Barrett SL, Cookson BT, et al. (2005) Evasion of Toll-like receptor 5 by flagellated bacteria. Proc Natl Acad Sci U S A 102: 9247-52. PMCID:PMC1166605. (Pubitemid 40923549)
43. Rad R, Ballhorn W, Voland P, Eisenächer K, Mages J, et al. (2009) Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori. Gastroenterology. 136:2247-57. PMID:19272387.
44. Khamri W, Walker MM, Clark P, Atherton JC, Thursz MR, et al. (2010) Helicobacter pylori stimulates dendritic cells to induce interleukin-17 expression from CD4+ T lymphocytes. Infect Immun 78: 845-853. PMID: 19917709, PMCID: PMC2812220.
45. Veldhoen M, Hirota K, Christensen J, O'Garra A, Stockinger B (2009) Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells. J Exp Med. 206:43-9. PMID:19114668.
46. Volpe E, Servant N, Zollinger R, Bogiatzi SI, Hupé P, et al. (2008) A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T (H)-17 responses. Nat Immunol 9: 650-7. PMID:18454150. (Pubitemid 351712635)
47. Zhang S, Moise L, Moss SF (2011) H. pylori vaccines: Why we still don't have any. Hum Vaccin 7: 1153-1157. PMCID: PMC3360072.
48. Czinn SJ, Blanchard T (2011) Vaccinating against Helicobacter pylori infection. Nat Rev Gastroenterol Hepatol 8: 133-140. PMID: 21304478.
49. Graham DY, Fischbach L (2010) Helicobacter pylori treatment in the era of increasing antibiotic resistance. Gut 59: 1143-1153. PMID: 20525969.
50. Malfertheiner P, Megraud F, O'Morain CA, Atherton J, Axon AT, et al. (2012) European Helicobacter Study Group. Management of Helicobacter pylori infection-the Maastricht IV/Florence Consensus Report. Gut 61: 646-664. PMID: 22491499.
51. Caraux G, Pinloche S (2005) PermutMatrix: A graphical environment to arrange gene expression profiles in optimal linear order. Bioinformatics 21: 1280-1281. PMID: 15546938. (Pubitemid 40467961)