Resistance to erythropoiesis stimulating agents in patients treated with online hemodiafiltration and ultrapure low-flux hemodialysis: Results from a randomized controlled trial (CONTRAST)

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Van Der Weerd, Neelke C ^a,b   Hoedt, Claire H Den ^c,d   Blankestijn, Peter J ^c   Bots, Michiel L ^c   Van Den Dorpel, Marinus A ^d   Lévesque, Renée ^e   Mazairac, Albert H A ^c   Nubé, Menso J ^b,f   Lars Penne, E ^b,g   Ter Wee, Pieter M ^b,f   Grooteman, Muriel P C ^b,f  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d Maasstad Hospital Rotterdam   (Netherlands)

^e St Luc Hospital   (Canada)

^f VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^g Location Alkmaar   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANEMIC AGENT; FERRITIN; HEMOGLOBIN; IRON; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; RECOMBINANT ERYTHROPOIETIN; TRANSFERRIN;

ADULT; ANEMIA; ARTICLE; ARTIFICIAL KIDNEY; DIET SUPPLEMENTATION; FEMALE; HEMATOCRIT; HEMATOLOGICAL PARAMETERS; HEMODIAFILTRATION; HEMODIALYSIS; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON SUPPLEMENTATION; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL (TOPIC); ULTRAPURE DIALYSIS FLUID; ULTRAPURE LOW FLUX HEMODIALYSIS; CONTROLLED STUDY; DRUG RESISTANCE; METABOLISM; MIDDLE AGED; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

DRUG RESISTANCE; FEMALE; HEMATINICS; HEMODIAFILTRATION; HEMOGLOBINS; HUMANS; IRON; MALE; MIDDLE AGED; TREATMENT OUTCOME;

EID: 84899727376     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094434     Document Type: Article

References (51)

1. Frank H, Heusser K, Hoffken B, Huber P, Schmieder RE, et al. (2004) Effect of erythropoietin on cardiovascular prognosis parameters in hemodialysis patients. Kidney Int 66: 832-840. (Pubitemid 38982028)
2. Foley RN, Curtis BM, Parfrey PS (2009) Erythropoietin therapy, hemoglobin targets, and quality of life in healthy hemodialysis patients: a randomized trial. ClinJAmSocNephrol 4: 726-733.
3. Besarab A, Bolton WK, Browne JK, Egrie JC, Nissenson AR, et al. (1998) The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin. NEnglJMed 339: 584-590. (Pubitemid 28385655)
4. Drueke TB, Locatelli F, Clyne N, Eckardt KU, Macdougall IC, et al. (2006) Normalization of hemoglobin level in patients with chronic kidney disease and anemia. NEnglJMed 355: 2071-2084. (Pubitemid 44749316)
5. Pfeffer MA, Burdmann EA, Chen CY, Cooper ME, de ZD, et al. (2009) A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. NEnglJMed 361: 2019-2032.
6. Singh AK, Szczech L, Tang KL, Barnhart H, Sapp S, et al. (2006) Correction of anemia with epoetin alfa in chronic kidney disease. NEnglJMed 355: 2085-2098. (Pubitemid 44749317)
7. Kalantar-Zadeh K, McAllister CJ, Lehn RS, Lee GH, Nissenson AR, et al. (2003) Effect of malnutrition-inflammation complex syndrome on EPO hyporesponsiveness in maintenance hemodialysis patients. AmJKidney Dis 42: 761-773. (Pubitemid 37187377)
8. Locatelli F, Andrulli S, Memoli B, Maffei C, Del VL, et al. (2006) Nutritional-inflammation status and resistance to erythropoietin therapy in haemodialysis patients. NephrolDialTransplant 21: 991-998.
9. Susantitaphong P, Riella C, Jaber BL (2013) Effect of ultrapure dialysate on markers of inflammation, oxidative stress, nutrition and anemia parameters: a meta-analysis. Nephrol Dial Transplant 28: 438-446.
10. Lee CT, Chou FF, Chang HW, Hsu YH, Lee WC, et al. (2003) Effects of parathyroidectomy on iron homeostasis and erythropoiesis in hemodialysis patients with severe hyperparathyroidism. Blood Purif 21: 369-375.
11. Movilli E, Cancarini GC, Zani R, Camerini C, Sandrini M, et al. (2001) Adequacy of dialysis reduces the doses of recombinant erythropoietin independently from the use of biocompatible membranes in haemodialysis patients. NephrolDialTransplant 16: 111-114. (Pubitemid 32051482)
12. Bosch JP, Lew SQ, Barlee V, Mishkin GJ, von AB (2006) Clinical use of high-efficiency hemodialysis treatments: long-term assessment. HemodialInt 10: 73-81. (Pubitemid 43263295)
13. Canaud B, Bragg-Gresham JL, Marshall MR, Desmeules S, Gillespie BW, et al. (2006) Mortality risk for patients receiving hemodiafiltration versus hemodialysis: European results from the DOPPS. Kidney Int 69: 2087-2093. (Pubitemid 43924275)
14. Jirka T, Cesare S, Di BA, Perera CM, Ponce P, et al. (2006) Mortality risk for patients receiving hemodiafiltration versus hemodialysis. Kidney Int 70: 1524-1525.
15. Vilar E, Fry AC, Wellsted D, Tattersall JE, Greenwood RN, et al. (2009) Long-term outcomes in online hemodiafiltration and high-flux hemodialysis: a comparative analysis. ClinJAmSocNephrol 4: 1944-1953.
16. Grooteman MP, van den Dorpel MA, Bots ML, Penne EL, van der Weerd NC, et al. (2012) Effect of Online Hemodiafiltration on All-Cause Mortality and Cardiovascular Outcomes. J Am Soc Nephrol 23: 1087-1096.
17. Ok E, Asci G, Toz H, Ok ES, Kircelli F, et al. (2013) Mortality and cardiovascular events in online haemodiafiltration (OL-HDF) compared with high-flux dialysis: results from the Turkish OL-HDF Study. Nephrol Dial Transplant 28: 192-202.
18. Maduell F, Moreso F, Pons M, Ramos R, Mora-Macia J, et al. (2013) High-efficiency postdilution online hemodiafiltration reduces all-cause mortality in hemodialysis patients. J Am Soc Nephrol 24: 487-497.
19. Macdougall IC (2001) Role of uremic toxins in exacerbating anemia in renal failure. Kidney IntSuppl 78: S67-S72. (Pubitemid 32144073)
20. Rioux JP, Chan CT (2010) Nocturnal home hemodialysis and its impact on erythropoietin responsiveness. Clin Nephrol 74: 167-172.
21. Kruse A, Uehlinger DE, Gotch F, Kotanko P, Levin NW (2008) Red blood cell lifespan, erythropoiesis and hemoglobin control. ContribNephrol 161: 247-254.
22. Ly J, Marticorena R, Donnelly S (2004) Red blood cell survival in chronic renal failure. Am J Kidney Dis 44: 715-719. (Pubitemid 39237616)
23. Lin CL, Huang CC, Yu CC, Wu CH, Chang CT, et al. (2002) Improved iron utilization and reduced erythropoietin resistance by on-line hemodiafiltration. Blood Purif 20: 349-356.
24. Penne EL, Blankestijn PJ, Bots ML, van den Dorpel MA, Grooteman MP, et al. (2005) Effect of increased convective clearance by on-line hemodiafiltration on all cause and cardiovascular mortality in chronic hemodialysis patients-the Dutch CONvective TRAnsport STudy (CONTRAST): rationale and design of a randomised controlled trial [ISRCTN38365125]. CurrControl Trials CardiovascMed 6: 8.
25. Locatelli F, Aljama P, Barany P, Canaud B, Carrera F, et al. (2004) Revised European best practice guidelines for the management of anaemia in patients with chronic renal failure. NephrolDialTransplant 19 Suppl 2: ii1-47.
26. (2006) KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease. AmJKidney Dis 47: S11-145.
27. (2007) KDOQI Clinical Practice Guideline and Clinical Practice Recommendations for anemia in chronic kidney disease: 2007 update of hemoglobin target. AmJKidney Dis 50: 471-530.
28. Ledebo I, Nystrand R (1999) Defining the microbiological quality of dialysis fluid. Artif Organs 23: 37-43. (Pubitemid 29047494)
29. Penne EL, Visser L, van den Dorpel MA, van der Weerd NC, Mazairac AH, et al. (2009) Microbiological quality and quality control of purified water and ultrapure dialysis fluids for online hemodiafiltration in routine clinical practice. Kidney Int 76: 665-672.
30. Kaysen GA, Muller HG, Ding J, Chertow GM (2006) Challenging the validity of the EPO index. AmJKidney Dis 47: 166.
31. Gambino R, Desvarieux E, Orth M, Matan H, Ackattupathil T, et al. (1997) The relation between chemically measured total iron-binding capacity concentrations and immunologically measured transferrin concentrations in human serum. ClinChem 43: 2408-2412. (Pubitemid 28022980)
32. Clase CM, St Pierre MW, Churchill DN (2001) Conversion between bromcresol green-and bromcresol purple-measured albumin in renal disease. Nephrol Dial Transplant 16: 1925-1929. (Pubitemid 32821429)
33. Daugirdas JT (1993) Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. JAmSocNephrol 4: 1205-1213.
34. Tattersall JE, Ward RA (2013) Online haemodiafiltration: definition, dose quantification and safety revisited. Nephrol Dial Transplant 28: 542-550.
35. Schiffl H (2007) Prospective randomized cross-over long-term comparison of online haemodiafiltration and ultrapure high-flux haemodialysis. EurJMedRes 12: 26-33.
36. Vaslaki L, Major L, Berta K, Karatson A, Misz M, et al. (2006) On-line haemodiafiltration versus haemodialysis: stable haematocrit with less erythro-poietin and improvement of other relevant blood parameters. Blood Purif 24: 163-173. (Pubitemid 43259169)
37. Bonforte G, Grillo P, Zerbi S, Surian M (2002) Improvement of anemia in hemodialysis patients treated by hemodiafiltration with high-volume on-line-prepared substitution fluid. Blood Purif 20: 357-363. (Pubitemid 34920517)
38. Oates T, Pinney JH, Davenport A (2011) Haemodiafiltration versus High-Flux Haemodialysis: Effects on Phosphate Control and Erythropoietin Response. AmJNephrol 33: 70-75.
39. Ward RA, Schmidt B, Hullin J, Hillebrand GF, Samtleben W (2000) A comparison of on-line hemodiafiltration and high-flux hemodialysis: a prospective clinical study. JAmSocNephrol 11: 2344-2350.
40. Wizemann V, Lotz C, Techert F, Uthoff S (2000) On-line haemodiafiltration versus low-flux haemodialysis. A prospective randomized study. NephrolDial-Transplant 15 Suppl 1: 43-48. (Pubitemid 30114209)
41. Locatelli F, Altieri P, Andrulli S, Sau G, Bolasco P, et al. (2012) Predictors of haemoglobin levels and resistance to erythropoiesis-stimulating agents in patients treated with low-flux haemodialysis, haemofiltration and haemodiafiltration: results of a multicentre randomized and controlled trial. Nephrol Dial Transplant 27: 3594-3600.
42. Asci G, Tz H, Ozkahya M, Duman S, Demirci MS, et al. (2013) The Impact of Membrane Permeability and Dialysate Purity on Cardiovascular Outcomes. J Am Soc Nephrol.
43. Hsu PY, Lin CL, Yu CC, Chien CC, Hsiau TG, et al. (2004) Ultrapure dialysate improves iron utilization and erythropoietin response in chronic hemodialysis patients-a prospective cross-over study. JNephrol 17: 693-700.
44. Johnson DW, Pollock CA, Macdougall IC (2007) Erythropoiesis-stimulating agent hyporesponsiveness. Nephrology(Carlton) 12: 321-330.
45. Sitter T, Bergner A, Schiffl H (2000) Dialysate related cytokine induction and response to recombinant human erythropoietin in haemodialysis patients. NephrolDialTransplant 15: 1207-1211. (Pubitemid 30487799)
46. Morena M, Cristol JP, Bosc JY, Tetta C, Forret G, et al. (2002) Convective and diffusive losses of vitamin C during haemodiafiltration session: a contributive factor to oxidative stress in haemodialysis patients. NephrolDialTransplant 17: 422-427. (Pubitemid 34211138)
47. Deved V, Poyah P, James MT, Tonelli M, Manns BJ, et al. (2009) Ascorbic acid for anemia management in hemodialysis patients: a systematic review and meta-analysis. AmJKidney Dis 54: 1089-1097.
48. Fouque D, Vennegoor M, ter WP, Wanner C, Basci A, et al. (2007) EBPG guideline on nutrition. NephrolDialTransplant 22 Suppl 2: ii45-ii87.
49. Klingel R, Schaefer M, Schwarting A, Himmelsbach F, Altes U, et al. (2004) Comparative analysis of procoagulatory activity of haemodialysis, haemofiltra-tion and haemodiafiltration with a polysulfone membrane (APS) and with different modes of enoxaparin anticoagulation. NephrolDialTransplant 19: 164-170. (Pubitemid 38072628)
50. Bock HA, Hirt-Minkowski P, Brunisholz M, Keusch G, Rey S, et al. (2008) Darbepoetin alpha in lower-than-equimolar doses maintains haemoglobin levels in stable haemodialysis patients converting from epoetin alpha/beta. Nephrol-DialTransplant 23: 301-308. (Pubitemid 351767386)
51. Tattersall J, Canaud B, Heimburger O, Pedrini L, Schneditz D, et al. (2010) High-flux or low-flux dialysis: a position statement following publication of the Membrane Permeability Outcome study. Nephrol Dial Transplant 25: 1230-1232.