Longterm treatment with endothelin receptor antagonist bosentan and iloprost improves fingertip blood perfusion in systemic sclerosis

Journal of Rheumatology

Volumn 41, Issue 5, 2014, Pages 881-886

  Cutolo, Maurizio ^a   Ruaro, Barbara ^c   Pizzorni, Carmen ^c   Ravera, Francesca ^a   Smith, Vanessa ^b   Zampogna, Giuseppe ^c   Paolino, Sabrina ^c   Seriolo, Bruno ^c   Cimmino, Marco ^c   Sulli, Alberto ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c NONE

Author keywords

Endothelin 1 antagonist; Iloprost; Laser doppler flowmetry; Nailfold videocapillaroscopy; Raynaud phenomenon; Systemic sclerosis

Indexed keywords

ACETYLSALICYLIC ACID; AMINOTRANSFERASE; ANTIHYPERTENSIVE AGENT; ANTINUCLEAR ANTIBODY; BOSENTAN; CENTROMERE ANTIBODY; ILOPROST; IMMUNOSUPPRESSIVE AGENT; PROTON PUMP INHIBITOR; ENDOTHELIN RECEPTOR ANTAGONIST; SULFONAMIDE; VASODILATOR AGENT;

ADULT; ARTICLE; CAPILLAROSCOPY; CLINICAL ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DISEASE COURSE; DISEASE DURATION; DRUG WITHDRAWAL; FEMALE; FINGER; FINGER BLOOD FLOW; FINGER ULCER; HUMAN; LASER DOPPLER FLOWMETRY; LONG TERM CARE; MALE; MICROANGIOPATHY; NAIL; PRIORITY JOURNAL; PROSPECTIVE STUDY; RAYNAUD PHENOMENON; SIDE EFFECT; SKIN TEMPERATURE; SYSTEMIC SCLEROSIS; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT; VASODILATATION; VIDEOCAPILLAROSCOPY; AGED; ANGIOSCOPY; BLOOD FLOW; CLINICAL TRIAL; DRUG EFFECTS; MIDDLE AGED; SCLERODERMA, SYSTEMIC; TIME; TREATMENT OUTCOME; VASCULARIZATION;

AGED; ENDOTHELIN RECEPTOR ANTAGONISTS; FEMALE; FINGERS; HUMANS; ILOPROST; LASER-DOPPLER FLOWMETRY; MALE; MICROSCOPIC ANGIOSCOPY; MIDDLE AGED; PROSPECTIVE STUDIES; REGIONAL BLOOD FLOW; SCLERODERMA, SYSTEMIC; SULFONAMIDES; TIME FACTORS; TREATMENT OUTCOME; VASODILATOR AGENTS;

EID: 84899717942     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.131284     Document Type: Article

References (18)

1. Cutolo M, Sulli A, Smith V. Assessing microvascular changes in systemic sclerosis diagnosis and management. Nat Rev Rheumatol 2010;6:578-87
2. Cutolo M, Ferrone C, Pizzorni C, Soldano S, Seriolo B, Sulli A. Peripheral blood perfusion correlates with microvascular abnormalities in systemic sclerosis: a laser-Doppler and nailfold videocapillaroscopy study. J Rheumatol 2010;37:1174-80
3. Rosato E, Molinaro I, Borghese F, Rossi C, Pisarri S, Salsano F. Bosentan improves skin perfusion of hands in patients with systemic sclerosis with pulmonary arterial hypertension. J Rheumatol 2010;37:2531-9
4. Herrick AL. Contemporary management of Raynaud's phenomenon and digital ischaemic complications. Curr Opin Rheumatol 2011;23:555-61
5. Sulli A, Ruaro B, Alessandri E, Pizzorni C, Cimmino MA, Zampogna G, et al. Correlations between nailfold microangiopathy severity, finger dermal thickness and fingertip blood perfusion in systemic sclerosis patients. Ann Rheum Dis 2014;73:247-51
6. Caramaschi P, Canestrini S, Martinelli N, Volpe A, Pieropan S, Ferrari M, et al. Scleroderma patients nailfold videocapillaroscopic patterns are associated with disease subset and disease severity. Rheumatology 2007;46:1566-9 (Pubitemid 47500571)
7. Mubarak KK. A review of prostaglandin analogs in the management of patients with pulmonary arterial hypertension. Respir Med 2010;104:9-21
8. Silver RM. Endothelin and scleroderma lung disease. Rheumatology 2008;47 Suppl 5:v25-6
9. Cutolo M, Zampogna G, Vremis L, Smith V, Pizzorni C, Sulli A. Longterm effects of endothelin receptor antagonism on microvascular damage evaluated by nailfold capillaroscopic analysis in systemic sclerosis. J Rheumatol 2013;40:40-5
10. Sulli A, Secchi ME, Pizzorni C, Cutolo M. Scoring the nailfold microvascular changes during the capillaroscopic analysis in systemic sclerosis patients. Ann Rheum Dis 2008;67:885-7 (Pubitemid 351829394)
11. Smith V, Pizzorni C, De Keyser F, Decuman S, Van Praet JT, Deschepper E, et al. Reliability of the quantitative and semiquantitative nailfold videocapillaroscopy assessment in a systemic sclerosis cohort: a two-centre study. Ann Rheum Dis 2010;69:1092-6
12. Smith V, De Keyser F, Pizzorni C, Van Praet JT, Decuman S, Sulli A, et al. A nailfold capillaroscopy for day-to-day clinical use: construction of a simple scoring modality as a clinical prognostic index for digital trophic lesions. Ann Rheum Dis 2011;70:180-3
13. Steen V, Denton CP, Pope JE, Matucci-Cerinic M. Digital ulcers: overt vascular disease in systemic sclerosis. Rheumatology 2009;48:iii19-24
14. Moore TL, Vail A, Herrick AL. Assessment of digital vascular structure and function in response to bosentan in patients with systemic sclerosis-related Raynaud's phenomenon. Rheumatology 2007;46:363-4 (Pubitemid 46189802)
15. Hettema ME, Zhang D, Stienstra Y, Smit AJ, Bootsma H, Kallenberg CG. No effects of bosentan on microvasculature in patients with limited cutaneous systemic sclerosis. Clin Rheumatol 2009;28:825-33
16. Guiducci S, Bellando-Randone S, Bruni C, Carnesecchi G, Maresta A, Iannone F, et al. Bosentan fosters microvascular de-remodelling in systemic sclerosis. Clin Rheumatol 2012;31:1723-5
17. Lambova SN, Müller-Ladner U. New lines in therapy of Raynaud's phenomenon. Rheumatol Int 2009;29:355-63
18. Sulli A, Ruaro B, Smith V, Pizzorni C, Zampogna G, Gallo M, et al. Progression of nailfold microvascular damage and antinuclear antibody pattern in systemic sclerosis. J Rheumatol 2013;40:634-9.