Recent structural alteration of the peripheral lamina cribrosa near the location of disc hemorrhage in glaucoma

Investigative Ophthalmology and Visual Science

Volumn 55, Issue 4, 2014, Pages 2805-2815

  Lee, Eun Ji ^a   Kim, Tae Woo ^a   Kim, Mijin ^a   Girard, Michaël J A ^b,c   Mari, Jean Martial ^d   Weinreb, Robert N ^e  

^a Seoul National University Bundang Hospital   (South Korea)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^d UNIVERSITÉ DE LYON   (France)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Disc hemorrhage; Lamina cribrosa; Primary open angle glaucoma; Spectral domain optical coherence tomography

Indexed keywords

ADULT; AGED; ARTICLE; B SCAN; CLINICAL ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CORNEA THICKNESS; EYE AXIS LENGTH; EYE REFRACTION; FEMALE; FOLLOW UP; GOLDMANN APPLANATION TONOMETER; GONIOSCOPY; HUMAN; HUMAN TISSUE; INTRAOCULAR HEMORRHAGE; LAMINA CRIBROSA; MALE; OPEN ANGLE GLAUCOMA; OPTIC DISK; OPTIC NERVE LESION; PRIORITY JOURNAL; SCLERA; SLIT LAMP; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; VISUAL ACUITY; VISUAL FIELD DEFECT;

DISC HEMORRHAGE; LAMINA CRIBROSA; PRIMARY OPEN-ANGLE GLAUCOMA; SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY;

ADULT; AGED; AGED, 80 AND OVER; EYE HEMORRHAGE; FEMALE; GLAUCOMA, OPEN-ANGLE; HUMANS; IMAGING, THREE-DIMENSIONAL; INTRAOCULAR PRESSURE; MALE; MIDDLE AGED; OPTIC DISK; OPTIC NERVE DISEASES; PROGNOSIS; TOMOGRAPHY, OPTICAL COHERENCE; YOUNG ADULT;

EID: 84899686718     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-12742     Document Type: Article

References (56)

1. Budenz DL, Anderson DR, Feuer WJ, et al. Detection and prognostic significance of optic disc hemorrhages during the Ocular Hypertension Treatment Study. Ophthalmology. 2006; 113:2137-2143.
2. Miglior S, Torri V, Zeyen T, et al. Intercurrent factors associated with the development of open-angle glaucoma in the European glaucoma prevention study. Am J Ophthalmol. 2007;144:266-275.
3. Drance S, Anderson DR, Schulzer M. Collaborative Normal-Tension Glaucoma Study G. Risk factors for progression of visual field abnormalities in normal-tension glaucoma. Am J Ophthalmol. 2001;131:699-708.
4. Leske MC, Heijl A, Hussein M, et al. Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial. Arch Ophthalmol. 2003;121:48-56.
5. Siegner SW, Netland PA. Optic disc hemorrhages and progression of glaucoma. Ophthalmology. 1996;103:1014-1024.
6. Rasker MT, van den Enden A, Bakker D, Hoyng PF. Deterioration of visual fields in patients with glaucoma with and without optic disc hemorrhages. Arch Ophthalmol. 1997; 115:1257-1262.
7. Ishida K, Yamamoto T, Sugiyama K, Kitazawa Y. Disk hemorrhage is a significantly negative prognostic factor in normal-tension glaucoma. Am J Ophthalmol. 2000;129:707-714.
8. Kim SH, Park KH. The relationship between recurrent optic disc hemorrhage and glaucoma progression. Ophthalmology. 2006;113:598-602.
9. Bengtsson B, Leske MC, Yang Z, Heijl A. Group E. Disc hemorrhages and treatment in the early manifest glaucoma trial. Ophthalmology. 2008;115:2044-2048.
10. Sugiyama K, Tomita G, Kitazawa Y, Onda E, Shinohara H, Park KH. The associations of optic disc hemorrhage with retinal nerve fiber layer defect and peripapillary atrophy in normaltension glaucoma. Ophthalmology. 1997;104:1926-1933.
11. Sugiyama K, Uchida H, Tomita G, Sato Y, Iwase A, Kitazawa Y. Localized wedge-shaped defects of retinal nerve fiber layer and disc hemorrhage in glaucoma. Ophthalmology. 1999;106: 1762-1767.
12. Gunvant P, Zheng Y, Essock EA, et al. Predicting subsequent visual field loss in glaucomatous subjects with disc hemorrhage using retinal nerve fiber layer polarimetry. J Glaucoma. 2005;14:20-25.
13. Hernandez MR. The optic nerve head in glaucoma: role of astrocytes in tissue remodeling. Prog Retin Eye Res. 2000;19: 297-321.
14. Diehl DL, Quigley HA, Miller NR, Sommer A, Burney EN. Prevalence and significance of optic disc hemorrhage in a longitudinal study of glaucoma. Arch Ophthalmol. 1990;108: 545-550.
15. Klein BE, Klein R, Sponsel WE, et al. Prevalence of glaucoma. The Beaver Dam Eye Study. Ophthalmology. 1992;99:1499-1504.
16. Hendrickx KH, van den Enden A, Rasker MT, Hoyng PF. Cumulative incidence of patients with disc hemorrhages in glaucoma and the effect of therapy. Ophthalmology. 1994; 101:1165-1172.
17. Jonas JB, Xu L. Optic disk hemorrhages in glaucoma. Am J Ophthalmol. 1994;118:1-8.
18. Healey PR, Mitchell P, Smith W, Wang JJ. Optic disc hemorrhages in a population with and without signs of glaucoma. Ophthalmology. 1998;105:216-223.
19. Suh MH, Park KH. Period prevalence and incidence of optic disc haemorrhage in normal tension glaucoma and primary open-angle glaucoma. Clin Exp Ophthalmol. 2011;39:513-519.
20. Airaksinen PJ, Mustonen E, Alanko HI. Optic disc hemorrhages. Analysis of stereophotographs and clinical data of 112 patients. Arch Ophthalmol. 1981;99:1795-1801.
21. Airaksinen PJ, Mustonen E, Alanko HI. Optic disc haemorrhages precede retinal nerve fibre layer defects in ocular hypertension. Acta Ophthalmol. 1981;59:627-641.
22. Quigley HA, Addicks EM, Green WR, Maumenee AE. Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage. Arch Ophthalmol. 1981;99:635-649.
23. Emery JM, Landis D, Paton D, Boniuk M, Craig JM. The lamina cribrosa in normal and glaucomatous human eyes. Trans Am Acad Ophthalmol Otolaryngol. 1974;78:OP290-OP297.
24. Radius RL, Gonzales M. Anatomy of the lamina cribrosa in human eyes. Arch Ophthalmol. 1981;99:2159-2162.
25. Nitta K, Sugiyama K, Higashide T, Ohkubo S, Tanahashi T, Kitazawa Y. Does the enlargement of retinal nerve fiber layer defects relate to disc hemorrhage or progressive visual field loss in normal-tension glaucoma? J Glaucoma. 2011;20:189-195.
26. Yang H, Williams G, Downs JC, et al. Posterior (outward) migration of the lamina cribrosa and early cupping in monkey experimental glaucoma. Invest Ophthalmol Vis Sci. 2011;52: 7109-7121.
27. Drance SM, Begg IS. Sector haemorrhage-a probable acute ischaemic disc change in chronic simple glaucoma. Can J Ophthalmol. 1970;5:137-141.
28. Begg IS, Drance SM, Sweeney VP. Haemorrhage on the disc-a sign of acute ischaemic optic neuropathy in chronic simple glaucoma. Can J Ophthalmol. 1970;5:321-330.
29. Begg IS, Drance SM, Sweeney VP. Ischaemic optic neuropathy in chronic simple glaucoma. Br J Ophthalmol. 1971;55:73-90.
30. Lichter PR, Henderson JW. Optic nerve infarction. Am J Ophthalmol. 1978;85:302-310.
31. Grieshaber MC, Terhorst T, Flammer J. The pathogenesis of optic disc splinter haemorrhages: a new hypothesis. Acta Ophthalmol Scand. 2006;84:62-68.
32. Golubnitschaja O, Yeghiazaryan K, Liu R, et al. Increased expression of matrix metalloproteinases in mononuclear blood cells of normal-tension glaucoma patients. J Glaucoma. 2004;13:66-72.
33. Kiumehr S, Park SC, Syril D, et al. In vivo evaluation of focal lamina cribrosa defects in glaucoma. Arch Ophthalmol. 2012; 130:552-559.
34. You JY, Park SC, Su D, Teng CC, Liebmann JM, Ritch R. Focal lamina cribrosa defects associated with glaucomatous rim thinning and acquired pits. JAMA Ophthalmol. 2013;131:314-320.
35. Tatham AJ, Miki A, Weinreb RN, Zangwill LM, Medeiros FA. Defects of the lamina cribrosa in eyes with localized retinal nerve fiber layer loss. Ophthalmology. 2014;121:110-118.
36. Park SC, Hsu AT, Su D, et al. Factors associated with focal lamina cribrosa defects in glaucoma. Invest Ophthalmol Vis Sci. 2013;54:8401-8407.
37. Radius RL, Maumenee AE, Green WR. Pit-like changes of the optic nerve head in open-angle glaucoma. Br J Ophthalmol. 1978;62:389-393.
38. Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol. 2008;146:496-500.
39. Lee EJ, Kim TW, Weinreb RN, Park KH, Kim SH, Kim DM. Visualization of the lamina cribrosa using enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol. 2011;152:87-95.
40. Girard MJ, Strouthidis NG, Ethier CR, Mari JM. Shadow removal and contrast enhancement in optical coherence tomography images of the human optic nerve head. Invest Ophthalmol Vis Sci. 2011;52:7738-7748.
41. Foin N, Mari JM, Davies JE, Di Mario C, Girard MJ. Imaging of coronary artery plaques using contrast-enhanced optical coherence tomography. Eur Heart J Cardiovasc Imaging. 2013;14:85.
42. Lee EJ, Kim TW, Weinreb RN, et al. Three-dimensional evaluation of the lamina cribrosa using spectral-domain optical coherence tomography in glaucoma. Invest Ophthalmol Vis Sci. 2012;53:198-204.
43. Lee EJ, Kim TW, Weinreb RN. Reversal of lamina cribrosa displacement and thickness after trabeculectomy in glaucoma. Ophthalmology. 2012;119:1359-1366.
44. Lee EJ, Kim TW, Weinreb RN, Kim H. Reversal of lamina cribrosa displacement after intraocular pressure reduction in open-angle glaucoma. Ophthalmology. 2013;120:553-559.
45. Chauhan BC, Burgoyne CF. From clinical examination of the optic disc to clinical assessment of the optic nerve head: a paradigm change. Am J Ophthalmol. 2013;156:218-227.
46. Jampel HD, Vitale S, Ding Y, et al. Test-retest variability in structural and functional parameters of glaucoma damage in the glaucoma imaging longitudinal study. J Glaucoma. 2006; 15:152-157.
47. Burgoyne CF, Downs JC, Bellezza AJ, Suh JK, Hart RT. The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage. Prog Retin Eye Res. 2005;24:39-73.
48. Quill B, Docherty NG, Clark AF, O'Brien CJ. The effect of graded cyclic stretching on extracellular matrix-related gene expression profiles in cultured primary human lamina cribrosa cells. Invest Ophthalmol Vis Sci. 2011;52:1908-1915.
49. Yang J, Yang P, Tezel G, Patil RV, Hernandez MR, Wax MB. Induction of HLA-DR expression in human lamina cribrosa astrocytes by cytokines and simulated ischemia. Invest Ophthalmol Vis Sci. 2001;42:365-371.
50. Park SC, Kiumehr S, Teng CC, Tello C, Liebmann JM, Ritch R. Horizontal central ridge of the lamina cribrosa and regional differences in laminar insertion in healthy subjects. Invest Ophthalmol Vis Sci. 2012;53:1610-1616.
51. Crawford Downs J, Roberts MD, Sigal IA. Glaucomatous cupping of the lamina cribrosa: a review of the evidence for active progressive remodeling as a mechanism. Exp Eye Res. 2011;93:133-140.
52. Quigley HA, Dorman-Pease ME, Brown AE. Quantitative study of collagen and elastin of the optic nerve head and sclera in human and experimental monkey glaucoma. Curr Eye Res. 1991;10:877-888.
53. Arend O, Plange N, Sponsel WE, Remky A. Pathogenetic aspects of the glaucomatous optic neuropathy: fluorescein angiographic findings in patients with primary open angle glaucoma. Brain Res Bull. 2004;62:517-524.
54. Downs JC, Roberts MD, Burgoyne CF. Mechanical environment of the optic nerve head in glaucoma. Optom Vis Sci. 2008;85: 425-435.
55. Ohno-Matsui K, Akiba M, Moriyama M, et al. Acquired optic nerve and peripapillary pits in pathologic myopia. Ophthalmology. 2012;119:1685-1692.
56. Takayama K, Hangai M, Kimura Y, et al. Three-dimensional imaging of lamina cribrosa defects in glaucoma using sweptsource optical coherence tomography. Invest Ophthalmol Vis Sci. 2013;54:4798-4807.