Prenatal exposure to glucocorticoids affects body weight, serum leptin levels, and hypothalamic neuropeptide-Y expression in pre-pubertal female rat offspring

International Journal of Developmental Neuroscience

Volumn 36, Issue , 2014, Pages 1-4

  Iwasa, Takeshi ^a   Matsuzaki, Toshiya ^a   Munkhzaya, Munkhsaikhan ^a   Tungalagsuvd, Altankhuu ^a   Kawami, Takako ^a   Murakami, Masahiro ^a   Yamasaki, Mikio ^a   Kato, Takeshi ^a   Kuwahara, Akira ^a   Yasui, Toshiyuki ^a   Irahara, Minoru ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Glucocorticoid; Leptin; NPY

Indexed keywords

GLUCOCORTICOID; LEPTIN; NEUROPEPTIDE Y; DEXAMETHASONE; MESSENGER RNA;

ANIMAL EXPERIMENT; APPETITE; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; GESTATION PERIOD; HORMONE BLOOD LEVEL; HORMONE SYNTHESIS; HYPOTHALAMUS; NEUROPEPTIDE Y GENE; NONHUMAN; PERINATAL PERIOD; PRENATAL EXPOSURE; PREPUBERTY; PRIORITY JOURNAL; PROGENY; RAT; UPREGULATION; WEIGHT CHANGE; WEIGHT GAIN; ANIMAL; BLOOD; BODY WEIGHT; DRUG EFFECTS; GENETICS; MALE; METABOLISM; NEWBORN; PATHOLOGY; PATHOPHYSIOLOGY; PREGNANCY; RADIOIMMUNOASSAY; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; DEXAMETHASONE; FEMALE; GLUCOCORTICOIDS; HYPOTHALAMUS; LEPTIN; MALE; NEUROPEPTIDE Y; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RADIOIMMUNOASSAY; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TIME FACTORS;

EID: 84899670885     PISSN: 07365748     EISSN: 1873474X     Source Type: Journal    
DOI: 10.1016/j.ijdevneu.2014.03.011     Document Type: Article

References (12)

1. Arsenault D., St-Amour I., Cisbani G., Rousseau L.S., Cicchetti F. The different effects of LPS and poly I:C prenatal immune challenges on the behaviour, development and inflammatory responses in pregnant mice and their offspring. Brain Behav. Immun. 2014, (in press).
2. Brabham T., Phelka A., Zimmer C., Nash A., Lopez J.F., Vazquez D.M. Effects of prenatal dexamethasone on spatial learning and response to stress is influenced by maternal factors. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2000, 279:1899-1909.
3. Iwasa T., Matsuzaki T., Kinouchi R., Gereltsetseg G., Murakami M., Nakazawa H., Yasui T., Irahara M. Changes in the responsiveness of serum leptin and hypothalamic neuropeptide Y mRNA levels to food deprivation in developing rats. Int. J. Dev. Neurosci. 2011, 29:377-380.
4. Iwasa T., Matsuzaki T., Murakami M., Kinouchi R., Osugi T., Gereltsetseg G., Yoshida S., Irahara M., Tsutsui K. Developmental changes in the mammalian gonadotropin-inhibitory hormone (GnIH) ortholog RFamide-related peptide (RFRP) and its cognate receptor GPR147 in the rat hypothalamus. Int. J. Dev. Neurosci. 2012, 30:31-37.
5. Iwasa T., Matsuzaki T., Munkhzaya M., Tungalagsuvd A., Kawami T., Murakami M., Yamasaki M., Kato T., Kuwahara A., Yasui T., Irahara M. Changes in the responsiveness of hypothalamic prokineticin 2 mRNA expression to food deprivation in developing female rats. Int. J. Dev. Neurosci. 2014, 34:76-78.
6. Kinouchi R., Matsuzaki T., Iwasa T., Gereltsetseg G., Nakazawa H., Kunimi K., Kuwahara A., Yasui T., Irahara M. Prepubertal exposure to glucocorticoid delays puberty independent of the hypothalamic Kiss1-GnRH system in female rats. Int. J. Dev. Neurosci. 2012, 30:596-601.
7. Nilsson C., Larsson B.M., Jennische E., Eriksson E., Bjorntorp P., York D.A., Holmang A. Maternal endotoxemia results in obesity and insulin resistance in adult male offspring. Endocrinology 2001, 142:2622-2630.
8. Nyirenda M.J., Welberg L.A.M., Seckl J.R. Programming hyperglycaemia in the rat through prenatal exposure to glucocorticoids - fetal effect or maternal influence?. J. Endocrinol. 2001, 170:653-660.
9. Sapolsky R.M., Romero L.M., Munck A.U. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr. Rev. 2000, 21:55-89.
10. Shanks N., Windle R.J., Perks P.A., Harbuz M.S., Jessop D.S., Ingram C.D., Lightmen S.L. Early-life exposure to endotoxin alters hypothalamic-pituitary-adrenal function and predisposition to inflammation. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:5645-5650.
11. Smith J.T., Waddell B.J. Increased fetal glucocorticoid exposure delays puberty onset in postnatal life. Endocrinology 2000, 141:2422-2428.
12. Stephens T.W., Basinski M., Bristow P.K., Bue-Valleskey J.M., Burgett S.G., Craft L., Hale J., Hoffmann J., Hsiung H.M. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995, 377:530-532.