Cerebral oxygenation during the Richalet hypoxia sensitivity test and cycling time-trial performance in severe hypoxia

European Journal of Applied Physiology

Volumn 114, Issue 5, 2014, Pages 1037-1048

  Bourdillon, Nicolas ^a   Fan, Jui Lin ^a   Kayser, Bengt ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Altitude; Brain; Exercise; Hypoxia; Performance

Indexed keywords

OXYHEMOGLOBIN;

ADULT; ALTITUDE; ANOXIA; BLOOD FLOW VELOCITY; BRAIN CIRCULATION; EXERCISE; EXERCISE TEST; HUMAN; MALE; METABOLISM; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; ALTITUDE; ANOXIA; BLOOD FLOW VELOCITY; CEREBROVASCULAR CIRCULATION; EXERCISE; EXERCISE TEST; HUMANS; MALE; OXYGEN CONSUMPTION; OXYHEMOGLOBINS;

EID: 84899631613     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-014-2835-8     Document Type: Article

References (54)

1. Ainslie PN, Ogoh S (2010) Regulation of cerebral blood flow in mammals during chronic hypoxia: a matter of balance. Exp Physiol 95:251-262
2. Amann M, Kayser B (2009) Nervous System Function during Exercise in Hypoxia. High Alt Med Biol 10:149-164
3. Amann M, Romer LM, Subudhi AW et al (2007) Severity of arterial hypoxaemia affects the relative contributions of peripheral muscle fatigue to exercise performance in healthy humans. J Physiol 581:389-403
4. Bernardi L, Schneider A, Pomidori L et al (2006) Hypoxic ventilatory response in successful extreme altitude climbers. Eur Respir J 27:165-171
5. Bourdillon N, Perrey S (2012) What does cerebral oxygenation tell us about central motor output? Neuroimaging. Cogn Clin Neurosci. doi: 10.5772/23609
6. Bourdillon N, Mollard P, Letournel M et al (2009) Interaction between hypoxia and training on NIRS signal during exercise: contribution of a mathematical model. Respir Physiol Neurobiol 169:50-61
7. Brugniaux JV, Hodges ANH, Hanly PJ, Poulin MJ (2007) Cerebrovascular responses to altitude. Respir Physiol Neurobiol 158:212-223
8. 2 delivery during exercise at altitude. High Alt Med Biol 10:123-134
9. Calbet JAL, Robach P, Lundby C (2009) The exercising heart at altitude. Cell Mol Life Sci 66:3601-3613
10. Chapman RF, Emery M, Stager JM (1999) Degree of arterial desaturation in normoxia influences VO2max decline in mild hypoxia. Med Sci Sports Exerc 31:658-663
11. Ekblom B, Huot R, Stein EM, Thorstensson AT (1975) Effect of changes in arterial oxygen content on circulation and physical performance. J Appl Physiol 39:71-75
12. Fan J-L, Kayser B (2013) The effect of adding CO2 to hypoxic inspired gas on cerebral blood flow velocity and breathing during incremental exercise. PLoS One 8:e81130
13. Fan J-L, Bourdillon N, Kayser B (2013) Effect of end-tidal CO2 clamping on cerebrovascular function, oxygenation, and performance during 15-km time trial cycling in severe normobaric hypoxia: the role of cerebral O2 delivery. Physiol Rep 1:e00066
14. Ferretti G, Moia C, Thomet JM, Kayser B (1997) The decrease of maximal oxygen consumption during hypoxia in man: a mirror image of the oxygen equilibrium curve. J Physiol 498(Pt 1):231-237
15. Gore CJ, Hahn AG, Scroop GC et al (1996) Increased arterial desaturation in trained cyclists during maximal exercise at 580 m altitude. J Appl Physiol 80:2204-2210
16. Hackett PH, Rennie D, Levine HD (1976) The incidence, importance, and prophylaxis of acute mountain sickness. Lancet 2:1149-1155
17. Hornbein TF, Townes BD, Schoene RB et al (1989) The cost to the central nervous system of climbing to extremely high altitude. N Engl J Med 321:1714-1719
18. Ide K, Horn A, Secher NH (1999) Cerebral metabolic response to submaximal exercise. J Appl Physiol 87:1604-1608
19. Jørgensen LG, Perko G, Secher NH (1992) Regional cerebral artery mean flow velocity and blood flow during dynamic exercise in humans. J Appl Physiol 73:1825-1830
20. Kayser B (2003) Exercise starts and ends in the brain. Eur J Appl Physiol 90:411-419
21. Kayser B, Narici M, Binzoni T et al (1994) Fatigue and exhaustion in chronic hypobaric hypoxia: influence of exercising muscle mass. J Appl Physiol 76:634-640
22. Kleinschmidt A, Obrig H, Requardt M et al (1996) Simultaneous recording of cerebral blood oxygenation changes during human brain activation by magnetic resonance imaging and near-infrared spectroscopy. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab 16:817-826
23. Koglin L, Kayser B (2013) Control and sensation of breathing during cycling exercise in hypoxia under naloxone: a randomised controlled crossover trial. Extrem Physiol Med 2:1
24. Lawler J, Powers SK, Thompson D (1988) Linear relationship between VO2max and VO2max decrement during exposure to acute hypoxia. J Appl Physiol 64:1486-1492
25. Lindegaard KF, Lundar T, Wiberg J et al (1987) Variations in middle cerebral artery blood flow investigated with noninvasive transcranial blood velocity measurements. Stroke J Cereb Circ 18:1025-1030
26. Madsen PL, Sperling BK, Warming T et al (1993) Middle cerebral artery blood velocity and cerebral blood flow and O2 uptake during dynamic exercise. J Appl Physiol 74:245-250
27. Martin D, O'Kroy J (1993) Effects of acute hypoxia on the VO2 max of trained and untrained subjects. J Sports Sci 11:37-42
28. Nishimura N, Iwasaki K, Ogawa Y, Aoki K (2010) Decreased steady-state cerebral blood flow velocity and altered dynamic cerebral autoregulation during 5-h sustained 15% O2 hypoxia. J Appl Physiol 108:1154-1161
29. Peltonen JE, Kowalchuk JM, Paterson DH et al (2007) Cerebral and muscle tissue oxygenation in acute hypoxic ventilatory response test. Respir Physiol Neurobiol 155:71-81
30. Peltonen JE, Paterson DH, Shoemaker JK et al (2009) Cerebral and muscle deoxygenation, hypoxic ventilatory chemosensitivity and cerebrovascular responsiveness during incremental exercise. Respir Physiol Neurobiol 169:24-35
31. Rasmussen P, Nielsen J, Overgaard M et al (2010) Reduced muscle activation during exercise related to brain oxygenation and metabolism in humans. J Physiol 588:1985-1995
32. Richalet JP, Rathat C, Keromes A et al (1983) Plasma volume, body weight, and acute mountain sickness. Lancet 1:525
33. Richalet J-P, Herry J-P, Blein J-P (2006) Médecine de l'alpinisme et des sports de montagne. Masson, Paris, pp 258-260
34. Richalet J-P, Larmignat P, Poitrine E et al (2012) Physiological risk factors for severe high-altitude illness: a prospective cohort study. Am J Respir Crit Care Med 185:192-198
35. Roach RC, Kayser B (2001) Exercise and hypoxia: performance, limits, and training. High Alt. Explor. Hum. Adapt., Marcel Dekker. T. Hornbein and R. B. Schoene, New York, pp 663-705
36. Roy SB, Guleria JS, Khanna PK et al (1968) Immediate circulatory response to high altitude hypoxia in man. Nature 217:1177-1178
37. Rupp T, Perrey S (2008) Prefrontal cortex oxygenation and neuromuscular responses to exhaustive exercise. Eur J Appl Physiol 102:153-163
38. 2 in human internal and external carotid and vertebral arteries. J Physiol 590:3277-3290
39. Schoene RB, Lahiri S, Hackett PH et al (1984) Relationship of hypoxic ventilatory response to exercise performance on Mount Everest. J Appl Physiol 56:1478-1483
40. Seifert T, Fisher JP, Young CN et al (2010) Glycopyrrolate abolishes the exercise-induced increase in cerebral perfusion in humans. Exp Physiol 95:1016-1025
41. Siggaard-Andersen O (1974) The acid-base status of the blood. Williams and Wilkins, Baltimore
42. Siggaard-Andersen O (2003) OSA.exe. Charlottenlund, Denmark
43. Smith KJ, Wong LE, Eves ND et al (2012) Regional cerebral blood flow distribution during exercise: influence of oxygen. Respir Physiol Neurobiol 184:97-105
44. Smith ZM, Krizay E, Guo J et al (2013) Sustained high-altitude hypoxia increases cerebral oxygen metabolism. J Appl Physiol 114:11-18
45. Strangman G, Culver JP, Thompson JH, Boas DA (2002) A quantitative comparison of simultaneous BOLD fMRI and NIRS recordings during functional brain activation. Neuroimage 17:719-731
46. Subudhi AW, Dimmen AC, Roach RC (2007) Effects of acute hypoxia on cerebral and muscle oxygenation during incremental exercise. J Appl Physiol 103:177-183
47. Subudhi AW, Lorenz MC, Fulco CS, Roach RC (2008) Cerebrovascular responses to incremental exercise during hypobaric hypoxia: effect of oxygenation on maximal performance. Am J Physiol Heart Circ Physiol 294:H164-H171
48. Subudhi AW, Miramon BR, Granger ME, Roach RC (2009) Frontal and motor cortex oxygenation during maximal exercise in normoxia and hypoxia. J Appl Physiol 106:1153-1158
49. Subudhi AW, Olin JT, Dimmen AC et al (2011) Does cerebral oxygen delivery limit incremental exercise performance? J Appl Physiol 111:1727-1734
50. Tew GA, Ruddock AD, Saxton JM (2010) Skin blood flow differentially affects near-infrared spectroscopy-derived measures of muscle oxygen saturation and blood volume at rest and during dynamic leg exercise. Eur J Appl Physiol 110:1083-1089
51. Van der Zee P, Cope M, Arridge SR et al (1992) Experimentally measured optical pathlengths for the adult head, calf and forearm and the head of the newborn infant as a function of inter optode spacing. Adv Exp Med Biol 316:143-153
52. Van Dorp E, Los M, Dirven P et al (2007) Inspired carbon dioxide during hypoxia: effects on task performance and cerebral oxygen saturation. Aviat Space Environ Med 78:666-672
53. Verges S, Rupp T, Jubeau M et al (2012) Cerebral perturbations during exercise in hypoxia. Am J Physiol Regul Integr Comp Physiol 302:R903-R916
54. Woorons X, Mollard P, Pichon A et al (2007) Moderate exercise in hypoxia induces a greater arterial desaturation in trained than untrained men. Scand J Med Sci Sports 17:431-436