β-Thalassemia and Polycythemia vera: Targeting chronic stress erythropoiesis

International Journal of Biochemistry and Cell Biology

Volumn 51, Issue 1, 2014, Pages 89-92

  Crielaard, Bart J ^a   Rivella, Stefano ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

beta; Thalassemia; Chronic stress erythropoiesis; Iron metabolism; Macrophages; Polycythemia vera

Indexed keywords

IMMUNOGLOBULIN A1; JANUS KINASE 2; STAT5 PROTEIN;

ARTICLE; BETA THALASSEMIA; CELL INTERACTION; CHRONIC STRESS ERYTHROPOIESIS; ERYTHROCYTE VOLUME; ERYTHROPOIESIS; HUMAN; IRON METABOLISM; IRON OVERLOAD; MACROPHAGE; NONHUMAN; PATHOGENESIS; PHENOTYPE; POLYCYTHEMIA VERA; STEADY STATE; ANIMAL; BLOOD; PHYSIOLOGY;

ANIMALS; BETA-THALASSEMIA; ERYTHROPOIESIS; HUMANS; POLYCYTHEMIA VERA;

EID: 84899573273     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2014.03.029     Document Type: Short Survey

References (30)

1. Sheila A. Anderson, P. Nizzi Christopher, Y.-I. Chang, M. Deck Kathryn, J. Schmidt Paul, and B. Galy et al. The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption Cell Metab 17 2013 282 290
2. A. Chow, M. Huggins, J. Ahmed, D. Hashimoto, D. Lucas, and Y. Kunisaki et al. CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress Nat Med 19 2013 429 436
3. S. Coulon, M. Dussiot, D. Grapton, T.T. Maciel, P.H.M. Wang, and C. Callens et al. Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia Nat Med 17 2011 1456 1465
4. J. Flygare, V.R. Estrada, C. Shin, S. Gupta, and H.F. Lodish HIF1 synergizes with glucocorticoids to promote BFU-E progenitor self-renewal Blood 117 2011 3435 3444
5. Y. Ginzburg, and S. Rivella β-Thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism Blood 118 2011 4321 4330
6. M.A. Goodell, E. Porpiglia, D. Hidalgo, M. Koulnis, A.R. Tzafriri, and M. Socolovsky Stat5 signaling specifies basal versus stress erythropoietic responses through distinct binary and graded dynamic modalities PLoS Biol 10 2012 e1001383
7. S. Guo, C. Casu, S. Gardenghi, S. Booten, M. Aghajan, and R. Peralta et al. Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice J Clin Invest 123 2013 1531 1541
8. V.H. Haase Regulation of erythropoiesis by hypoxia-inducible factors Blood Rev 27 2013 41 53
9. M.W. Hentze, M.U. Muckenthaler, B. Galy, and C. Camaschella Two to tango: regulation of mammalian iron metabolism Cell 142 2010 24 38
10. D.R. Higgs, J.D. Engel, and G. Stamatoyannopoulos Thalassaemia Lancet 379 2012 373 383
11. M.A. Kerenyi, F. Grebien, H. Gehart, M. Schifrer, M. Artaker, and B. Kovacic et al. Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1 Blood 112 2008 3878 3888
12. C.I. Lau, S.V. Outram, J. Ignacio Saldana, A.L. Furmanski, J.T. Dessens, and T. Crompton Regulation of murine normal and stress-induced erythropoiesis by Desert Hedgehog Blood 119 2012 4741 4751
13. L.E. Lenox, J.M. Perry, and R.F. Paulson BMP4 and Madh5 regulate the erythroid response to acute anemia Blood 105 2005 2741 2748
14. H. Li, A.C. Rybicki, S.M. Suzuka, L. von Bonsdorff, W. Breuer, and C.B. Hall et al. Transferrin therapy ameliorates disease in β-thalassemic mice Nat Med 16 2010 177 182
15. I.V. Libani, E.C. Guy, L. Melchiori, R. Schiro, P. Ramos, and L. Breda et al. Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in β-thalassemia Blood 112 2008 875 885
16. R. Marchioli, G. Finazzi, G. Specchia, R. Cacciola, R. Cavazzina, and D. Cilloni et al. Cardiovascular events and intensity of treatment in polycythemia vera N Engl J Med 368 2013 22 33
17. P. Oh, C. Lobry, J. Gao, A. Tikhonova, E. Loizou, and J. Manent et al. In vivo mapping of notch pathway activity in normal and stress hematopoiesis Cell Stem Cell 13 2013 190 204
18. J.M. Perry, O.F. Harandi, and R.F. Paulson BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors Blood 109 2007 4494 4502
19. J.M. Perry, O.F. Harandi, P. Porayette, S. Hegde, A.K. Kannan, and R.F. Paulson Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling Blood 113 2009 911 918
20. S.A. Peslak, J. Wenger, J.C. Bemis, P.D. Kingsley, A.D. Koniski, and K.E. McGrath et al. EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress Blood 120 2012 2501 2511
21. E. Ramos, P. Ruchala, J.B. Goodnough, L. Kautz, G.C. Preza, and E. Nemeth et al. Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis Blood 120 2012 3829 3836
22. P. Ramos, C. Casu, S. Gardenghi, L. Breda, B.J. Crielaard, and E. Guy et al. Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia Nat Med 19 2013 437 445
23. P.J. Schmidt, I. Toudjarska, A.K. Sendamarai, T. Racie, S. Milstein, and B.R. Bettencourt et al. An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe-/- mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia Blood 121 2012 1200 1208
24. M. Socolovsky Ineffective erythropoiesis in Stat5a-/-5b-/- mice due to decreased survival of early erythroblasts Blood 98 2001 3261 3273
25. A. Tefferi, E. Rumi, G. Finazzi, H. Gisslinger, A.M. Vannucchi, and F. Rodeghiero et al. Survival and prognosis among 1545 patients with contemporary polycythemia vera: an international study Leukemia 27 2013 1874 1881
26. T. Ulyanova, S.M. Padilla, and T. Papayannopoulou Stage specific functional roles of integrins in erythropoiesis Exp Hematol 2014 [Epub ahead of print]
27. L. Varricchio, V. Tirelli, E. Masselli, B. Ghinassi, N. Saha, and P. Besmer et al. The expression of the glucocorticoid receptor in human erythroblasts is uniquely regulated by KIT ligand: implications for stress erythropoiesis Stem Cells Dev 21 2012 2852 2865
28. S. Vemula, B. Ramdas, P. Hanneman, J. Martin, H.E. Beggs, and R. Kapur Essential role for focal adhesion kinase in regulating stress hematopoiesis Blood 116 2010 4103 4115
29. Z. Wang, O. Vogel, G. Kuhn, M. Gassmann, and J. Vogel Decreased stability of erythroblastic islands in integrin β3-deficient mice Physiol Rep 1 2013 e00018
30. L. Zhang, L. Prak, V. Rayon-Estrada, P. Thiru, J. Flygare, and B. Lim et al. ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors Nature 499 2013 92 96