Interplay between CXCR2 and BLT1 facilitates neutrophil infiltration and resultant keratinocyte activation in a murine model of imiquimod-induced psoriasis

Journal of Immunology

Volumn 192, Issue 9, 2014, Pages 4361-4369

  Sumida, Hayakazu ^a   Yanagida, Keisuke ^a,b   Kita, Yoshihiro ^a   Abe, Jun ^c   Matsushima, Kouji ^c   Nakamura, Motonao ^a   Ishii, Satoshi ^a   Sato, Shinichi ^a   Shimizu, Takao ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3 (4 BIPHENYLYLMETHYL) 4 HYDROXYCHROMAN 7 YL]CYCLOPENTANECARBOXYLIC ACID; CHEMOKINE RECEPTOR CXCR2; IMIQUIMOD; INTERLEUKIN 19; INTERLEUKIN 1BETA; LEUKOTRIENE B4 RECEPTOR; LEUKOTRIENE B4 RECEPTOR 1; UNCLASSIFIED DRUG; ZILEUTON;

ACANTHOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CELL ACTIVATION; CELL ISOLATION; CONTROLLED STUDY; DEPLETION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATION; KERATINOCYTE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ADJUVANTS, IMMUNOLOGIC; AMINOQUINOLINES; ANIMALS; CHEMOTAXIS, LEUKOCYTE; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; KERATINOCYTES; MICE; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; NEUTROPHILS; PSORIASIS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, INTERLEUKIN-8B; RECEPTORS, LEUKOTRIENE B4;

EID: 84899551203     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1302959     Document Type: Article

References (48)

1. Perera, G. K., P. Di Meglio, and F. O. Nestle. 2012. Psoriasis. Annu. Rev. Pathol. 7: 385-422
2. Pelletier, M., L. Maggi, A. Micheletti, E. Lazzeri, N. Tamassia, C. Costantini, L. Cosmi, C. Lunardi, F. Annunziato, S. Romagnani, and M. A. Cassatella. 2010. Evidence for a cross-talk between human neutrophils and Th17 cells. Blood 115: 335-343
3. Amulic, B., C. Cazalet, G. L. Hayes, K. D. Metzler, and A. Zychlinsky. 2012. Neutrophil function: From mechanisms to disease. Annu. Rev. Immunol. 30: 459-489
4. MantoVani, A., M. A. Cassatella, C. Costantini, and S. Jaillon. 2011. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat. Rev. Immunol. 11: 519-531
5. Sadik, C. D., N. D. Kim, and A. D. Luster. 2011. Neutrophils cascading their way to inflammation. Trends Immunol. 32: 452-460
6. Albanesi, C., C. Scarponi, D. Bosisio, S. Sozzani, and G. Girolomoni. 2010. Immune functions and recruitment of plasmacytoid dendritic cells in psoriasis. Autoimmunity 43: 215-219
7. Lew, W., E. Lee, and J. G. Krueger. 2004. Psoriasis genomics: Analysis of proinflammatory (type 1) gene expression in large plaque (Western) and small plaque (Asian) psoriasis vulgaris. Br. J. Dermatol. 150: 668-676
8. Iversen, L., K. Kragballe, and V. A. Ziboh. 1997. Significance of leukotriene-A4 hydrolase in the pathogenesis of psoriasis. Skin Pharmacol. 10: 169-177
9. Toichi, E., T. Tachibana, and F. Furukawa. 2000. Rapid improvement of psoriasis vulgaris during drug-induced agranulocytosis. J. Am. Acad. Dermatol. 43: 391-395
10. Van Der Fits, L., S. Mourits, J. S. Voerman, M. Kant, L. Boon, J. D. Laman, F. Cornelissen, A. M. Mus, E. Florencia, E. P. Prens, and E. Lubberts. 2009. Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J. Immunol. 182: 5836-5845
11. Schön, M. P., M. Schön, and K. N. Klotz. 2006. The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7-and TLR8-independent fashion. J. Invest. Dermatol. 126: 1338-1347
12. Terawaki, K., T. Yokomizo, T. Nagase, A. Toda, M. Taniguchi, K. Hashizume, T. Yagi, and T. Shimizu. 2005. Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2-type immune responses. J. Immunol. 175: 4217-4225
13. Jamieson, T., D. N. Cook, R. J. Nibbs, A. Rot, C. Nixon, P. McLean, A. Alcami, S. A. Lira, M. Wiekowski, and G. J. Graham. 2005. The chemokine receptor D6 limits the inflammatory response in vivo. Nat. Immunol. 6: 403-411
14. Jamieson, T., M. Clarke, C. W. Steele, M. S. Samuel, J. Neumann, A. Jung, D. Huels, M. F. Olson, S. Das, R. J. Nibbs, and O. J. Sansom. 2012. Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. J. Clin. Invest. 122: 3127-3144
15. Hikiji, H., S. Ishii, T. Yokomizo, T. Takato, and T. Shimizu. 2009. A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss. Proc. Natl. Acad. Sci. USA 106: 21294-21299
16. Kita, Y., T. Takahashi, N. Uozumi, and T. Shimizu. 2005. A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry. Anal. Biochem. 342: 134-143
17. Buerger, C., B. Richter, K. Woth, R. Salgo, B. Malisiewicz, S. Diehl, K. Hardt, S. Boehncke, and W. H. Boehncke. 2012. Interleukin-1b interferes with epidermal homeostasis through induction of insulin resistance: Implications for psoriasis pathogenesis. J. Invest. Dermatol. 132: 2206-2214
18. Daley, J. M., A. A. Thomay, M. D. Connolly, J. S. Reichner, and J. E. Albina. 2008. Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice. J. Leukoc. Biol. 83: 64-70
19. Serbina, N. V., and E. G. Pamer. 2006. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat. Immunol. 7: 311-317
20. Kulke, R., E. Bornscheuer, C. Schluter, J. Bartels, J. Röwert, M. Sticherling, and E. Christophers. 1998. The CXC receptor 2 is overexpressed in psoriatic epidermis. J. Invest. Dermatol. 110: 90-94
21. Yokomizo, T., T. Izumi, K. Chang, Y. Takuwa, and T. Shimizu. 1997. A Gprotein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 387: 620-624
22. Ford-Hutchinson, A. W., M. A. Bray, M. V. Doig, M. E. Shipley, and M. J. Smith. 1980. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286: 264-265
23. Funk, C. D. 2001. Prostaglandins and leukotrienes: AdVances in eicosanoid biology. Science 294: 1871-1875
24. Shimizu, T. 2009. Lipid mediators in health and disease: Enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation. Annu. Rev. Pharmacol. Toxicol. 49: 123-150
25. Yokomizo, T. 2011. Leukotriene B4 receptors: Novel roles in immunological regulations. Adv. Enzyme Regul. 51: 59-64
26. Chan, J. R.,W. Blumenschein, E. Murphy, C. Diveu, M.Wiekowski, S. Abbondanzo, L. Lucian, R. Geissler, S. Brodie, A. B. Kimball, et al. 2006. IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J. Exp. Med. 203: 2577-2587
27. Sa, S. M., P. A. Valdez, J. Wu, K. Jung, F. Zhong, L. Hall, I. Kasman, J. Winer, Z. Modrusan, D. M. Danilenko, and W. Ouyang. 2007. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J. Immunol. 178: 2229-2240
28. Li, H. H., Y. C. Lin, P. J. Chen, C. H. Hsiao, J. Y. Lee, W. C. Chen, T. Y. Tzung, J. C. Wu, and M. S. Chang. 2005. Interleukin-19 upregulates keratinocyte growth factor and is associated with psoriasis. Br. J. Dermatol. 153: 591-595
29. Gillitzer, R., U. Ritter, U. Spandau, M. Goebeler, and E. B. Bröcker. 1996. Differential expression of GRO-alpha and IL-8 mRNA in psoriasis: A model for neutrophil migration and accumulation in vivo. J. Invest. Dermatol. 107: 778-782
30. Sutton, C. E., S. J. Lalor, C. M. Sweeney, C. F. Brereton, E. C. Lavelle, and K. H. Mills. 2009. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 31: 331-341
31. Gray, E. E., F. Ramérez-Valle, Y. Xu, S. Wu, Z. Wu, K. E. Karjalainen, and J. G. Cyster. 2013. Deficiency in IL-17-committed Vg4(+) gd T cells in a spontaneous Sox13-mutant CD45.1(+) congenic mouse substrain provides protection from dermatitis. Nat. Immunol. 14: 584-592
32. Uribe-Herranz, M., L. H. Lian, K. M. Hooper, K. A. Milora, and L. E. Jensen. 2013. IL-1R1 signaling facilitates Munro?s microabscess formation in psoriasiform imiquimod-induced skin inflammation. J. Invest. Dermatol. 133: 1541-1549
33. Chaudhari, U., P. Romano, L. D. Mulcahy, L. T. Dooley, D. G. Baker, and A. B. Gottlieb. 2001. Efficacy and safety of infliximab monotherapy for plaquetype psoriasis: A randomised trial. Lancet 357: 1842-1847
34. Mease, P. J., B. S. Goffe, J. Metz, A. VanderStoep, B. Finck, and D. J. Burge. 2000. Etanercept in the treatment of psoriatic arthritis and psoriasis: A randomised trial. Lancet 356: 385-390
35. Arenberger, P., L. Kemény, R. Suss, G. Michel, R. U. Peter, and T. Ruzicka. 1992. Interleukin-8 receptors in normal and psoriatic polymorphonuclear leukocytes. Acta Derm. Venereol. 72: 334-336
36. Zhang, Z., G. Cherryholmes, F. Chang, D. M. Rose, I. Schraufstatter, and J. E. Shively. 2009. Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils. Eur. J. Immunol. 39: 3181-3194
37. Frohm, M., B. Agerberth, G. Ahangari, M. Stâhle-Bäckdahl, S. Lidén, H. Wigzell, and G. H. Gudmundsson. 1997. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J. Biol. Chem. 272: 15258-15263
38. Morizane, S., and R. L. Gallo. 2012. Antimicrobial peptides in the pathogenesis of psoriasis. J. Dermatol. 39: 225-230
39. Wan, M., A. Sabirsh, A. Wetterholm, B. Agerberth, and J. Z. Haeggström. 2007. Leukotriene B4 triggers release of the cathelicidin LL-37 from human neutrophils: Novel lipid-peptide interactions in innate immune responses. FASEB J. 21: 2897-2905
40. Kim, N. D., R. C. Chou, E. Seung, A. M. Tager, and A. D. Luster. 2006. A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis. J. Exp. Med. 203: 829-835
41. Oyoshi, M. K., R. He, Y. Li, S. Mondal, J. Yoon, R. Afshar, M. Chen, D. M. Lee, H. R. Luo, A. D. Luster, et al. 2012. Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity 37: 747-758
42. Chou, R. C., N. D. Kim, C. D. Sadik, E. Seung, Y. Lan, M. H. Byrne, B. Haribabu, Y. Iwakura, and A. D. Luster. 2010. Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis. Immunity 33: 266-278
43. Afonso, P. V., M. Janka-Junttila, Y. J. Lee, C. P. McCann, C. M. Oliver, K. A. Aamer, W. Losert, M. T. Cicerone, and C. A. Parent. 2012. LTB4 is a signal-relay molecule during neutrophil chemotaxis. Dev. Cell 22: 1079-1091
44. Sadik, C. D., N. D. Kim, Y. Iwakura, and A. D. Luster. 2012. Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcgR signaling. Proc. Natl. Acad. Sci. USA 109: E3177-E3185
45. Lämmermann, T., P. V. Afonso, B. R. Angermann, J. M. Wang, W. Kastenmuller, C. A. Parent, and R. N. Germain. 2013. Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature 498: 371-375
46. Bélanger, C., H. Elimam, J. Lefebvre, P. Borgeat, and S. Marleau. 2008. Involvement of endogenous leukotriene B4 and platelet-activating factor in polymorphonuclear leucocyte recruitment to dermal inflammatory sites in rats. Immunology 124: 295-303
47. Fretland, D. J., R. Gokhale, L. Mathur, D. A. Baron, S. K. Paulson, and J. Stolzenbach. 1995. Dermal inflammation in primates, mice, and guinea pigs: Attenuation by second-generation leukotriene B4 receptor antagonist, SC-53228. Inflammation 19: 333-346
48. Mommers, J. M., M. M. Van Rossum, M. E. Kooijmans-Otero, G. L. Parker, and P. C.Van De Kerkhof. 2000. VML 295 (LY-293111), a novel LTB4 antagonist, is not effective in the prevention of relapse in psoriasis. Br. J. Dermatol. 142: 259-266