Changes in salivary hormones, immunoglobulin A, and C-reactive protein in response to ultra-endurance exercises

Applied Physiology, Nutrition and Metabolism

Volumn 39, Issue 5, 2014, Pages 560-565

  Tauler, Pedro ^a   Martinez, Sonia ^a   Moreno, Carlos ^a   Martínez, Pau ^a   Aguilo, Antoni ^a  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

Author keywords

Cortisol; Crp; Iga; Saliva; Salivary flow rate; Testosterone; Ultra endurance exercises

Indexed keywords

C REACTIVE PROTEIN; HYDROCORTISONE; IMMUNOGLOBULIN A; TESTOSTERONE;

ADULT; CHEMISTRY; ENDURANCE; EXERCISE; FEMALE; HUMAN; MALE; PHYSIOLOGY; SALIVA;

ADULT; C-REACTIVE PROTEIN; EXERCISE; FEMALE; HUMANS; HYDROCORTISONE; IMMUNOGLOBULIN A; MALE; PHYSICAL ENDURANCE; SALIVA; TESTOSTERONE;

EID: 84899537698     PISSN: 17155312     EISSN: 17155320     Source Type: Journal    
DOI: 10.1139/apnm-2013-0466     Document Type: Article

References (39)

1. Bishop, N.C., and Gleeson, M. 2009. Acute and chronic effects of exercise on markers of mucosal immunity. Front. Biosci. 14:4444-4456.
2. Cadore, E., Lhullier, F., Brentano, M., Silva, E., Ambrosini, M., Spinelli, R., Silva, R., and Kruel, L. 2008. Correlations between serum and salivary hormonal concentrations in response to resistance exercise. J. Sports Sci. 26(10): 1067-1072. doi:10.1080/02640410801919526.
3. Chicharro, J.L., Lucia, A., Perez, M., Vaquero, A.F., and Urena, R. 1998. Saliva composition and exercise. Sports Med. 26(1): 17-27. doi:10.2165/00007256-199826010-00002.
4. Cook, N.J., Ng, A., Read, G.F., Harris, B., and Riad-Fahmy, D. 1987. Salivary cortisol for monitoring adrenal activity during marathon runs. Horm. Res. 25(1): 18-23. doi:10.1159/000180628.
5. Cumming, D.C., Quigley, M.E., andYen, S.S. 1983.Acute suppression of circulating testosterone levels by cortisol in men. J. Clin. Endocrinol. Metab. 57(3): 671-673. doi:10.1210/jcem-57-3-671.
6. Daly, W., Seegers, CA., Rubin, DA., Dobridge, J.D., and Hackney, A.C. 2005. Relationship between stress hormones and testosterone with prolonged endurance exercise. Eur.J.Appl. Physiol. 93(4): 375-380. doi:10.1007/s00421-004-1223-1.
7. Davies, C.T., and Few, J.D. 1973. Effects of exercise on adrenocortical function. J. Appl. Physiol. 35(6): 887-891.
8. Fahlman, M.M., and Engels, H.J. 2005. Mucosal IgAandURTI inAmerican college football players: a year longitudinal study. Med. Sci. Sports Exerc. 37(3): 374-380. doi:10.1249/01.MSS.0000155432.67020.88.
9. Friden, J., and Lieber, R.L. 1992. Structural and mechanical basis of exercise- induced muscle injury. Med. Sci. Sports Exerc. 24(5): 521-530. doi:10.1249/00005768-199205000-00005.
10. Froehlich, DA., Pangborn, R.M., and Whitaker, J.R. 1987. The effect of oral stimulation on human parotid salivary flow rate and alpha-amylase secretion. Physiol. Behav. 41(3): 209-217. doi:10.1016/0031-9384(87)90355-6.
11. Gatti, R., and De Palo, E.F. 2011. An update: salivary hormones and physical exercise. Scand. J. Med. Sci. Sports, 21(2): 157-169. doi:10.1111/j.1600-0838.2010.01252.x.
12. Gleeson, M., and Pyne, D.B. 2000. Special feature for the Olympics: effects of exercise on the immune system: exercise effects on mucosal immunity. Immunol. Cell Biol. 78(5): 536-544. doi:10.1111/j.1440-1711.2000.t01-8-.x.
13. Gleeson, M., McDonald, W.A., Pyne, D.B., Cripps, A.W., Francis, J.L., Fricker, PA., and Clancy, R.L. 1999. Salivary IgA levels and infection risk in elite swimmers. Med. Sci. Sports Exerc. 31(1): 67-73. doi:10.1097/00005768-199901000-00012.
14. Hill, E.E., Zack, E., Battaglini, C., Viru, M., Viru, A., and Hackney, A.C. 2008. Exercise and circulating cortisol levels: the intensity threshold effect. J. Endocrinol. Invest. 31(7): 587-591.
15. Jacks, D.E., Sowash, J., Anning, J., McGloughlin, T., and Andres, F. 2002. Effect of exercise at three exercise intensities on salivary cortisol. J. Strength Cond. Res. 16(2): 286-289. doi:10.1519/00124278-200205000-00018.
16. Kim, H.J., Lee, Y.H., and Kim, C.K. 2007. Biomarkers of muscle and cartilage damage and inflammation during a 200 km run. Eur. J. Appl. Physiol. 99(4): 443-447. doi:10.1007/s00421-006-0362-y.
17. Kraemer, W.J., Fragala, M.S., Watson, G., Volek, J.S., Rubin, M.R., French, D.N., et al. 2008. Hormonal responses to a 160-km race across frozen Alaska. Br. J. Sports Med. 42(2): 116-120; discussion 20. doi:10.1136/bjsm.2007.035535.
18. Loebel, C., and Kraemer, W. 1998. A brief review: testosterone and resistance exercise in men. J. Strength Cond. Res. 12(1): 57-63. doi:10.1519/1533-4287(1998)012<0057:ABRTAR>2.3.C0;2.
19. Mastaloudis, A., Morrow, J.D., Hopkins, D.W., Devaraj, S., and Traber, M.G. 2004. Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners. Free Radic. Biol. Med. 36(10): 1329-1341. doi:10.1016/j.freeradbiomed.2004.02.069.
20. McGuigan, M.R., Egan, A.D., and Foster, C. 2004. Salivary cortisol responses and perceived exertion during high intensity and low intensity bouts of resistance exercise. J. Sport Sci. Med. 3: 8-15.
21. Miles, M.P., Walker, E.E., Conant, S.B., Hogan, S.P., and Kidd, J.R. 2006. Carbohydrate influences plasma interleukin-6 but not C-reactive protein or creatine kinase following a 32-km mountain trail race. Int. J. Sport Nutr. Exerc. Metab. 16(1): 36-46.
22. Neville, V., Gleeson, M., and Folland, J.P. 2008. Salivary IgA as a risk factor for upper respiratory infections in elite professional athletes. Med. Sci. Sports Exerc. 40(7): 1228-1236. doi:10.1249/MSS.0b013e31816be9c3.
23. Nieman, D.C., Henson, DA., Fagoaga, O.R., Utter, A.C., Vinci, D.M., Davis, J.M., and Nehlsen-Cannarella, S.L. 2002. Change in salivary IgA following a competitive marathon race. Int. J. Sports Med. 23(1): 69-75. doi:10.1055/s-2002-19375.
24. Nieman, D.C., Henson, DA., Dumke, C.L., Lind, R.H., Shooter, L.R., and Gross, S.J. 2006. Relationship between salivary IgA secretion and upper respiratory tract infection following a 160-km race. J. Sports Med. Phys. Fitness, 46(1): 158-162.
25. Oliveira, E.B., Gotschlich, C., and Liu, T.Y. 1979. Primary structure of human C-reactive protein. J. Biol. Chem. 254(2): 489-502.
26. Ouellet-Morin, I., Danese, A., Williams, B., andArseneault, L. 2011.Validation of a high-sensitivity assay for C-reactive protein in human saliva. Brain Behav Immun. 25(4): 640-646. doi:10.1016/j.bbi.2010.12.020.
27. Palmer, F.M., Nieman, D.C., Henson, D.A., McAnulty, S.R., McAnulty, L., Swick, N.S., et al. 2003. Influence of vitamin C supplementation on oxidative and salivary IgA changes following an ultramarathon. Eur. J. Appl. Physiol. 89(1): 100-107. doi:10.1007/s00421-002-0756-4.
28. Papacosta, E., and Nassis, G.P. 2011. Saliva as a tool for monitoring steroid, peptide and immune markers in sport and exercise science. J. Sci. Med. Sport, 14(5): 424-434. doi:10.1016/j.jsams.2011.03.004.
29. Pedersen, B.K., and Hoffman-Goetz, L. 2000. Exercise and the immune system: regulation, integration, and adaptation. Physiol. Rev. 80(3): 1055-1081.
30. Pepys, M.B., and Hirschfield, G.M. 2003. C-reactive protein: a critical update. J. Clin. Invest. 111(12): 1805-1812. doi:10.1172/JCI200318921.
31. Peters, E.M., Anderson, R., and Theron, A.J. 2001. Attenuation of increase in circulating cortisol and enhancement of the acute phase protein response in vitamin C-supplemented ultramarathoners. Int.J. Sports Med. 22(2): 120-126. doi:10.1055/s-2001-11364.
32. Petraglia, F., Barletta, C., Facchinetti, F., Spinazzola, F., Monzani, A., Scavo, D., and Genazzani, A.R. 1988. Response of circulating adrenocorticotropin, beta- endorphin, beta-lipotropin and cortisol to athletic competition. Acta Endocrinol. (Copenh.), 118(3): 332-336. doi:10.1530/acta.0.1180332.
33. Rudolph, D.L., and McAuley, E. 1998. Cortisol and affective responses to exercise. J. Sports Sci. 16(2): 121-128. doi:10.1080/026404198366830.
34. Scheele, K., Herzog, W., Ritthaler, G., Wirth, A., and Weicker, H. 1979. Metabolic adaptation to prolonged exercise. Eur. J. Appl. Physiol. Occup. Physiol. 41(2): 101-108. doi:10.1007/BF00421657.
35. Suzuki, K., Peake, J., Nosaka, K., Okutsu, M., Abbiss, C.R., Surriano, R., etal. 2006. Changes in markers of muscle damage, inflammation and HSP70 after an Ironman Triathlon race. Eur. J. Appl. Physiol. 98(6): 525-534. doi:10.1007/s00421-006-0296-4.
36. Tanaka, H., Cleroux, J., de Champlain, J., Ducharme, J.R., and Collu, R. 1986. Persistent effects of a marathon run on the pituitary-testicular axis. J. Endocrinol. Invest. 9(2): 97-101.
37. Thomas, N.E., Leyshon, A., Hughes, M.G., Davies, B., Graham, M., and Baker, J.S. 2009. The effect of anaerobic exercise on salivary cortisol, testosterone and immunoglobulin (A) in boys aged 15-16 years. Eur. J. Appl. Physiol. 107(4): 455-461. doi:10.1007/s00421-009-1146-y.
38. Viru, A. 1985. The pituitary-adrenocortical system. In Hormones in Muscular Activity: Hormonal ensemble in exercise. Boca Raton: CRC Press Inc., pp. 25-36.
39. Walsh, N.P., Montague, J.C., Callow, N., and Rowlands, A.V. 2004. Saliva flow rate, total protein concentration and osmolality as potential markers of whole body hydration status during progressive acute dehydration in humans. Arch. Oral Biol. 49(2): 149-154. doi:10.1016/j.archoralbio.2003.08.001.