MicroRNA-203 inhibits the progression of esophageal squamous cell carcinoma with restored epithelial tissue architecture in vivo

International Journal of Oncology

Volumn 45, Issue 6, 2014, Pages 1923-1932

  Okumura, Tomoyuki ^a   Shimada, Yutaka ^a,b   Moriyama, Makoto ^a   Takei, Yoshinori ^b   Omura, Tetsuya ^a   Sekine, Shinichi ^a   Nagata, Takuya ^a   Shimizu, Kazuharu ^b   Tsukada, Kazuhiro ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Basal cells; Differentiation; Esophageal cancer; miR 203; Tissue architecture

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; COMPLEMENTARY DNA; INVOLUCRIN; KI 67 ANTIGEN; LAMININ; MICRORNA; MICRORNA 203; NEUROTROPHIN RECEPTOR P75; PROTEIN P63; PROTEIN ZO1; UNCLASSIFIED DRUG; MIRN203 MICRORNA, HUMAN; MIRN203 MICRORNA, MOUSE; BMI1 PROTEIN; COLLAGEN TYPE 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; EPITHELIUM; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STABLE TRANSFECTION; TISSUE STRUCTURE; TUMOR XENOGRAFT; UPREGULATION; AGED; ANIMAL; BAGG ALBINO MOUSE; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; DRUG SCREENING; ESOPHAGEAL NEOPLASMS; EXPERIMENTAL NEOPLASM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; KERATINOCYTE; MALE; METABOLISM; MIDDLE AGED; NEOPLASMS, BASAL CELL; PATHOLOGY; TUMOR CELL LINE; VERY ELDERLY; ADULT; BASEMENT MEMBRANE; CANCER GROWTH; CANCER STAGING; CARCINOGENESIS; CELL RENEWAL; CROSS LINKING; DISTANT METASTASIS; GENE EXPRESSION; HUMAN TISSUE; IN VITRO STUDY; LYMPH NODE METASTASIS; PROMOTER REGION;

AGED; AGED, 80 AND OVER; ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; ESOPHAGEAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KERATINOCYTES; MALE; MICE; MICE, INBRED BALB C; MICRORNAS; MIDDLE AGED; NEOPLASMS, BASAL CELL; NEOPLASMS, EXPERIMENTAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84899524018     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2365     Document Type: Article

References (34)

1. Thallinger CM, Raderer M and Hejna M: Esophageal cancer: a critical evaluation of systemic second-line therapy. J Clin Oncol 29: 4709-4714, 2011.
2. Watt FM: Stem cell fate and patterning in mammalian epidermis. Curr Opin Genet Dev 11: 410-417, 2001.
3. Bilder D, Li M and Perrimon N: Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289: 113-116, 2000.
4. Visvader JE and Lindeman GJ: Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8: 755-768, 2008.
5. Ginestier C, Wicinski J, Cervera N, Monville F, Finetti P, Bertucci F, et al: Retinoid signaling regulates breast cancer stem cell differentiation. Cell Cycle 8: 3297-3302, 2009.
6. Baek D, Villén J, Shin C, Camargo FD, Gygi SP and Bartel DP: The impact of microRNAs on protein output. Nature 455: 464-471, 2008.
7. Lena AM, Shalom-Feuerstein R, Rivetti di Val Cervo P, Aberdam D, Knight RA, Melino G and Candi E: miR-203 represses 'stemness' by repressing DeltaNp63. Cell Death Differ 15: 1187-1195, 2008.
8. Yi R, Poy MN, Stoffel M and Fuchs E: A skin microRNA promotes differentiation by repressing 'stemness'. Nature 452: 225-229, 2008.
9. Okumura T, Tsunoda S, Mori Y, Ito T, Kikuchi K, Wang TC, et al: The biological role of the low-affinity p75 neurotrophin receptor in esophageal squamous cell carcinoma. Clin Cancer Res 12: 5096-5103, 2006.
10. Shimada Y, Imamura M, Wagata T, Yamaguchi N and Tobe T: Characterization of 21 newly established esophageal cancer cell lines. Cancer 69: 277-284, 1992.
11. Sobin LH, Gospodarowicz M and Wittekind C (eds): TNM Classification of Malignant Tumours. UICC International Union Against Cancer 2010. 7th edition. Wiley-Blackwell, Hoboken, NJ, 2010.
12. Osawa S, Shimada Y, Sekine S, Okumura T, Nagata T, Fukuoka J and Tsukada K: MicroRNA profiling of gastric cancer patients from formalin-fixed paraffin-embedded samples. Oncol Lett 2: 613-619, 2011.
13. Okumura T, Shimada Y, Imamura M and Yasumoto S: Neuro trophin receptor p75(NTR) characterizes human esophageal keratinocyte stem cells in vitro. Oncogene 22: 4017-4026, 2003.
14. Liu S, Dontu G, Mantle ID, Patel S, Ahn NS, Jackson KW, Suri P and Wicha MS: Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 66: 6063-6071, 2006.
15. Hosen N, Yamane T, Muijtjens M, Pham K, Clarke MF and Weissman IL: Bmi-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells. Stem Cells 25: 1635-1644, 2007.
16. Koster MI, Kim S, Mills AA, DeMayo FJ and Roop DR: p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev 18: 126-131, 2004.
17. Jin J, Deng J, Wang F, Xia X, Qiu T, Lu W, Li X, Zhang H, Gu X, Liu Y, Cao W and Shao W: The expression and function of microRNA-203 in lung cancer. Tumour Biol 34: 349-357, 2013.
18. Daniely Y, Liao G, Dixon D, Linnoila RI, Lori A, Randell SH, et al: Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. Am J Physiol Cell Physiol 287: C171-C181, 2004.
19. Truong AB, Kretz M, Ridky TW, Kimmel R and Khavari PA: p63 regulates proliferation and differentiation of developmentally mature keratinocytes. Genes Dev 20: 3185-3197, 2006.
20. Wang C, Zheng X, Shen C and Shi Y: MicroRNA-203 suppresses cell proliferation and migration by targeting BIRC5 and LASP1 in human triple-negative breast cancer cells. J Exp Clin Cancer Res 31: 58, 2012.
21. Viticchiè G, Lena AM, Latina A, Formosa A, Gregersen LH, Lund AH, et al: MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines. Cell Cycle 10: 1121-1131, 2011.
22. Yuan Y, Zeng ZY, Liu XH, Gong DJ, Tao J, Cheng HZ and Huang SD: MicroRNA-203 inhibits cell proliferation by repressing ΔNp63 expression in human esophageal squamous cell carcinoma. BMC Cancer 11: 57, 2011.
23. Takeshita N, Mori M, Kano M, Hoshino I, Akutsu Y, Hanari N, et al: miR-203 inhibits the migration and invasion of esophageal squamous cell carcinoma by regulating LASP1. Int J Oncol 41: 1653-1661, 2012.
24. Yurchenco PD: Basement membranes: cell scaffoldings and signaling platforms. Cold Spring Harb Perspect Biol 3: pii: a004911, 2011.
25. Yoshida S, Yasuda M, Miyashita H, Ogawa Y, Yoshida T, Matsuzaki Y, et al: Generation of stratified squamous epithelial progenitor cells from mouse induced pluripotent stem cells. PLoS One 6: e28856, 2011.
26. Nagaoka K, Udagawa T and Richter JD: CPEB-mediated ZO-1 mRNA localization is required for epithelial tight-junction assembly and cell polarity. Nat Commun 3: 675, 2012.
27. Daley WP, Gervais EM, Centanni SW, Gulfo KM, Nelson DA and Larsen M: ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity. Development 139: 411-422, 2012.
28. Zen K, Yasui K, Gen Y, Dohi O, Wakabayashi N, Mitsufuji S, et al: Defective expression of polarity protein PAR-3 gene (PARD3) in esophageal squamous cell carcinoma. Oncogene 28: 2910-2918, 2009.
29. Bryant DM and Mostov KE: From cells to organs: building polarized tissue. Nat Rev Mol Cell Biol 9: 887-901, 2008.
30. Pellegrini G, Dellambra E, Golisano O, Martinelli E, Fantozzi I, Bondanza S, et al: p63 identifies keratinocyte stem cells. Proc Natl Acad Sci USA 98: 3156-3161, 2001.
31. Saini S, Majid S, Yamamura S, Tabatabai L, Suh SO, Shahryari V, et al: Regulatory role of miR-203 in prostate cancer progression and metastasis. Clin Cancer Res 17: 5287-5298, 2011.
32. Boll K, Reiche K, Kasack K, Mörbt N, Kretzschmar AK, Tomm JM, et al: MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma. Oncogene 32: 277-285, 2012.
33. Nakamura T, Endo K and Kinoshita S: Identification of human oral keratinocyte stem/progenitor cells by neurotrophin receptor p75 and the role of neurotrophin/p75 signaling. Stem Cells 25: 628-638, 2007.
34. Huang SD, Yuan Y, Liu XH, Gong DJ, Bai CG, Wang F, et al: Self-renewal and chemotherapy resistance of p75NTR positive cells in esophageal squamous cell carcinomas. BMC Cancer 9: 9, 2009.