The corepressor Atrophin specifies odorant receptor expression in Drosophila

FASEB Journal

Volumn 28, Issue 3, 2014, Pages 1355-1364

  Alkhori, Liza ^a   Öst, Anita ^b   Alenius, Mattias ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

Epigenetic; HDAC; Neuronal differentiation; Notch; Olfactory system

Indexed keywords

ATROPHIN; HISTONE DEACETYLASE 3; HISTONE H3; NOTCH RECEPTOR; ODORANT RECEPTOR; PROTEIN; RECEPTOR; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; GRUNGE PROTEIN, DROSOPHILA; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DROSOPHILA; GENE EXPRESSION; GENE REPRESSION; GENETIC REGULATION; HISTONE ACETYLATION; IMMUNOHISTOCHEMISTRY; NERVE CELL DIFFERENTIATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SEGREGATION ANALYSIS; SENSORY NERVE CELL; ANIMAL; EPIGENETIC; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HDAC; IN SITU HYBRIDIZATION; NOTCH; OLFACTORY RECEPTOR; OLFACTORY SYSTEM; PHYSIOLOGY;

EPIGENETIC; HDAC; NEURONAL DIFFERENTIATION; NOTCH; OLFACTORY SYSTEM;

ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE; IN SITU HYBRIDIZATION; RECEPTORS, ODORANT; TRANSCRIPTION FACTORS;

EID: 84899522295     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-240325     Document Type: Article

References (29)

1. Couto, A., Alenius, M., and Dickson, B. J. (2005) Molecular, anatomical, and functional organization of the Drosophila olfactory system. Curr. Biol. 15, 1535-1547
2. Fishilevich, E., and Vosshall, L. B. (2005) Genetic and functional subdivision of the Drosophila antennal lobe. Curr. Biol. 15, 1548-1553
3. Fuss, S. H., and Ray, A. (2009) Mechanisms of odorant receptor gene choice in Drosophila and vertebrates. Mol. Cell. Neurosci. 41, 101-112
4. Goulding, S. E., zur Lage, P., and Jarman, A. P. (2000) amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge. Neuron 25, 69-78
5. Gupta, B. P., and Rodrigues, V. (1997) Atonal is a proneural gene for a subset of olfactory sense organs in Drosophila. Genes Cells 2, 225-233
6. Endo, K., Aoki, T., Yoda, Y., Kimura, K., and Hama, C. (2007) Notch signal organizes the Drosophila olfactory circuitry by diversifying the sensory neuronal lineages. Nat. Neurosci. 10, 153-160
7. Jafari, S., Alkhori, L., Schleiffer, A., Brochtrup, A., Hummel, T., and Alenius, M. (2012). Combinatorial activation and repression by seven transcription factors specify Drosophila odorant receptor expression. PLoS Biol. 10, e1001280
8. Bai, L., Goldman, A. L., and Carlson, J. R. (2009) Positive and negative regulation of odor receptor gene choice in Drosophila by acj6. J. Neurosci. 29, 12940-12947
9. Miller, C. J., and Carlson, J. R. (2010) Regulation of odor receptor genes in trichoid sensilla of the Drosophila antenna. Genetics 186, 79-95
10. Sim, C. K., Perry, S., Tharadra, S. K., Lipsick, J. S., and Ray, A. (2012) Epigenetic regulation of olfactory receptor gene expression by the Myb-MuvB/dREAM complex. Genes Dev. 26, 2483-2498
11. Wang, L., and Tsai, C. C. (2008) Atrophin proteins: an overview of a new class of nuclear receptor corepressors. Nucl. Recept. Signal. 6, e009
12. Koide, R., Ikeuchi, T., Onodera, O., Tanaka, H., Igarashi, S., Endo, K., Takahashi, H., Kondo, R., Ishikawa, A., Hayashi, T., Saito, M., Tomoda, A. Miike, T., Naito, H., Ikuta, F. and Tsuji, S. (1994) Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA). Nat. Genet. 6, 9-13
13. Nagafuchi, S., Yanagisawa, H., Ohsaki, E., Shirayama, T., Tadokoro, K., Inoue, T., and Yamada, M. (1994) Structure and expression of the gene responsible for the triplet repeat disorder, dentatorubral and pallidoluysian atrophy (DRPLA). Nat. Genet. 8, 177-182
14. Yang, C. H., Axelrod, J. D., and Simon, M. A. (2002) Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye. Cell 108, 675-688
15. Wang, L., Charroux, B., Kerridge, S., and Tsai, C. C. (2008) Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates. EMBO. Rep. 9, 555-562
16. Charroux, B., Freeman, M., Kerridge, S., and Baonza, A. (2006) Atrophin contributes to the negative regulation of epidermal growth factor receptor signaling in Drosophila. Dev. Biol. 291, 278-290
17. Gray, S., and Levine, M. (1996) Transcriptional repression in development. Curr. Opin. Cell Biol. 8, 358-364
18. Shen, Y., and Peterson, A. S. (2009) Atrophins' emerging roles in development and neurodegenerative disease. Cell. Mol. Life Sci. 66, 437-446
19. Endo, K., Karim, M. R., Taniguchi, H., Krejci, A., Kinameri, E., Siebert, M., Ito, K., Bray, S. J., and Moore, A. W. (2012) Chromatin modification of Notch targets in olfactory receptor neuron diversification. Nat. Neurosci. 15, 224-233
20. McGuire, S. E., Mao, Z., and Davis, R. L. (2004). Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila. Sci. STKE 2004, pl6
21. De Ruijter, A. J., van Gennip, A. H., Caron, H. N., Kemp, S., and van Kuilenburg, A. B. (2003) Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem. J. 370, 737-749
22. Bhaskara, S., Knutson, S. K., Jiang, G., Chandrasekharan, M. B., Wilson, A. J., Zheng, S., Yenamandra, A., Locke, K., Yuan, J. L., Bonine-Summers, A. R., Wells, C. E., Kaiser, J. F., Washington, M. K., Zhao, Z., Wagner, F. F., Sun, Z.-W., Xia, F., Holson, E. B., Khabele, D., and Hiebert, S. W. (2010) Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell 18, 436-447
23. Knutson, S. K., Chyla, B. J., Amann, J. M., Bhaskara, S., Huppert, S. S., and Hiebert, S. W. (2008) Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J. 27, 1017-1028
24. Flici, H., Erkosar, B., Komonyi, O., Karatas, O. F., Laneve, P., and Giangrande, A. (2011) Gcm/Glide-dependent conversion into glia depends on neural stem cell age, but not on division, triggering a chromatin signature that is conserved in vertebrate glia. Development 138, 4167-4178
25. Haecker, A., Qi, D., Lilja, T., Moussian, B., Andrioli, L. P., Luschnig, S., and Mannervik, M. (2007) Drosophila brakeless interacts with atrophin and is required for tailless-mediated transcriptional repression in early embryos. PLoS. Biol. 5, e145
26. Zhang, S., Xu, L., Lee, J., and Xu, T. (2002) Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes. Cell 108, 45-56
27. De la Cruz, X., Lois, S., Sanchez-Molina, S., and Martinez-Balbas, M. A. (2005) Do protein motifs read the histone code? Bioessays 27, 164-175
28. Martinez, C. A., and Arnosti, D. N. (2008) Spreading of a corepressor linked to action of long-range repressor hairy. Mol. Cell. Biol. 28, 2792-2802
29. Chen, G., and Courey, A. J. (2000) Groucho/TLE family proteins and transcriptional repression. Gene 249, 1-16