Kappa-opioid receptor antagonism: A mechanism for treatment of relief drinking?

Biological Psychiatry

Volumn 75, Issue 10, 2014, Pages 750-751

  Heilig, Markus ^a   Schank, Jesse R ^b  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; DYNORPHIN; ENDORPHIN; KAPPA OPIATE RECEPTOR ANTAGONIST; MU OPIATE RECEPTOR; NALMEFENE; NALTREXONE; NORBINALTORPHIMINE; ALCOHOL; CENTRAL DEPRESSANT AGENT; DYNORPHIN RECEPTOR; KAPPA OPIATE RECEPTOR; OPIATE RECEPTOR;

ALCOHOL CONSUMPTION; ALCOHOL INTOXICATION; ALCOHOLISM; CENTRAL NUCLEUS (AMYGDALA); EMOTIONALITY; HUMAN; NONHUMAN; NOTE; PRIORITY JOURNAL; ANIMAL; MALE; METABOLISM;

ALCOHOLISM; ANIMALS; CENTRAL AMYGDALOID NUCLEUS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; MALE; RECEPTORS, OPIOID; RECEPTORS, OPIOID, KAPPA;

EID: 84899509190     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2014.03.004     Document Type: Note

References (10)

1. B.M. Walker, and G.F. Koob Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence Neuropsychopharmacology 33 2008 643 652
2. J.L. Kissler, S. Sirohi, D.J. Reis, H.T. Jansen, R.M. Quock, and D.G. Smith et al. The one-two punch of alcoholism: Role of central amygdala dynorphins/kappa-opioid receptors Biol Psychiatry 75 2014 774 782
3. S. Wee, L. Orio, S. Ghirmai, J.R. Cashman, and G.F. Koob Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine Psychopharmacology 205 2009 565 575
4. J.E. Schlosburg, T.W. Whitfield Jr, P.E. Park, E.F. Crawford, O. George, and L.F. Vendruscolo et al. Long-term antagonism of kappa opioid receptors prevents escalation of and increased motivation for heroin intake J Neurosci 33 2013 19384 19392
5. B.M. Walker, E.P. Zorrilla, and G.F. Koob Systemic kappa-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats Addict Biol 16 2011 116 119
6. J.R. Schank, A.L. Goldstein, K.E. Rowe, C.E. King, J.A. Marusich, and J.L. Wiley et al. The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety Addict Biol 17 2012 634 647
7. J.M. Mitchell, M.T. Liang, and H.L. Fields A single injection of the kappa opioid antagonist norbinaltorphimine increases ethanol consumption in rats Psychopharmacology 182 2005 384 392
8. M.R. Bruchas, T. Yang, S. Schreiber, M. Defino, S.C. Kwan, and S. Li et al. Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase J Biol Chem 282 2007 29803 29811
9. I. Carroll, J.B. Thomas, L.A. Dykstra, A.L. Granger, R.M. Allen, J.L. Howard, G.T. Pollard, M.D. Aceto, and L.S. Harris Pharmacological properties of JDTic: a novel kappa-opioid receptor antagonist Eur Journal of Pharmacol 501 2004 111 119
10. B.B. Land, M.R. Bruchas, J.C. Lemos, M. Xu, E.J. Melief, and C. Chavkin The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system J Neurosci 28 2008 407 414