Association of serum Clara cell protein CC16 with respiratory infections and immune response to respiratory pathogens in elite athletes

Respiratory Research

Volumn 15, Issue 1, 2014, Pages

  Kurowski, Marcin ^a   Jurczyk, Janusz ^b   Jarzebska, Marzanna ^a   Moskwa, Sylwia ^a   Makowska, Joanna S ^a   Krysztofiak, Hubert ^b   Kowalski, Marek L ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b National Centre for Sports Medicine   (Poland)

Author keywords

Allergy; Asthma; Clara cell protein; Club cell protein; Exercise training; Respiratory viruses

Indexed keywords

CC16 PROTEIN; CLARA CELL PROTEIN; IMMUNOGLOBULIN G; SALBUTAMOL; UNCLASSIFIED DRUG; VIRUS ANTIBODY; BIOLOGICAL MARKER; SCGB1A1 PROTEIN, HUMAN; UTEROGLOBIN;

ADENOVIRUS; ADULT; ALLERGIC ASTHMA; ALLERGIC RHINITIS; ARTICLE; ATHLETE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; IMMUNE RESPONSE; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; MYCOPLASMA PNEUMONIAE; PARAINFLUENZA VIRUS; PRACTICE GUIDELINE; PROTEIN BLOOD LEVEL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY VIRUS; SEROLOGY; ADOLESCENT; BLOOD; CELLULAR IMMUNITY; ENDURANCE; EXERCISE; IMMUNOLOGY; MIDDLE AGED; PHYSIOLOGY; RESPIRATORY TRACT INFECTION; SPORT; YOUNG ADULT;

ADOLESCENT; ADULT; ATHLETES; BIOLOGICAL MARKERS; EXERCISE; FEMALE; HUMANS; IMMUNITY, CELLULAR; MALE; MIDDLE AGED; PHYSICAL ENDURANCE; RESPIRATORY TRACT INFECTIONS; SPORTS; UTEROGLOBIN; YOUNG ADULT;

EID: 84899493673     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-15-45     Document Type: Article

References (29)

1. Helenius I, Rytilä P, Metso P, Haahtela T, Venge P, Tikkanen H. Respiratory symptoms, bronchial responsiveness, and cellular characteristics of induced sputum in elite swimmers. Allergy 1998, 53:346-352. 10.1111/j.1398-9995.1998.tb03904.x, 9574875.
2. Helenius I, Tikkanen H, Sarna S, Haahtela T. Asthma and increased bronchial responsiveness in elite athletes: atopy and sport event as risk factors. J Allergy Clin Immunol 1998, 101:646-652. 10.1016/S0091-6749(98)70173-3, 9600502.
3. Carlsen K. Sports in extreme conditions: the impact of exercise in cold temperatures on asthma and bronchial hyper-responsiveness in athletes. Br J Sports Med 2012, 46:796-799. 10.1136/bjsports-2012-091292, 22906782.
4. Carlsen K-H, Kowalski ML. Asthma, allergy, the athlete and the Olympics. Allergy 2008, 63:383-386. 10.1111/j.1398-9995.2008.01630.x, 18315726.
5. Walsh N, Gleeson M, Shephard R, Gleeson M, Woods J, Bishop N, Fleshner M, Green C, Pedersen BK, Hoffman-Goetz L, Rogers CJ, Northoff H, Abbasi A, Simon P. Position statement. Part one: immune function and exercise. Exerc Immunol Rev 2011, 17:6-63.
6. Bougault V, Turmel J, St-Laurent J, Bertrand M, Boulet LP. Asthma, airway inflammation and epithelial damage in swimmers and cold-air athletes. Eur Respir J 2009, 33:740-746. 10.1183/09031936.00117708, 19129276.
7. Font-Ribera L, Kogevinas M, Zock J, Gómez F, Barreiro E, Nieuwenhuijsen M, Fernandez P, Lourencetti C, Pérez-Olabarría M, Bustamante M, Marcos R, Grimalt JO, Villanueva CM. Short-term changes in respiratory biomarkers after swimming in a chlorinated pool. Environ Health Perspect 2010, 118:1538-1544. 10.1289/ehp.1001961, 2974690, 20833607.
8. Shorter J, Nelson D, McManus J, Zahniser M, Sama S, Milton D. Clinical study of multiple breath biomarkers of asthma and COPD (NO, CO(2), CO and N(2)O) by infrared laser spectroscopy. J Breath Res 2011, 5:037108. doi:10.1088/1752-7155/5/3/, 10.1088/1752-7155/5/3/037108, 3169766, 21757803.
9. Braido F, Bagnasco D, Scichilone N, Santus P, Solidoro P, Di Marco F, Corsico A, Canonica GW. Biomarkers in obstructive respiratory diseases: an update. Panminerva Med 2012, 54:119-127.
10. Broeckaert F, Bernard A. Clara cell secretory protein (CC16): characteristics and perspectives as lung peripheral biomarker. Clin Exp Allergy 2000, 30:469-475. 10.1046/j.1365-2222.2000.00760.x, 10718843.
11. LaKind J, Holgate S, Ownby D, Mansur A, Helms P, Pyatt D, Hays SM. A critical review of the use of Clara cell secretory protein (CC16) as a biomarker of acute or chronic pulmonary effects. Biomarkers 2007, 12:445-467. 10.1080/13547500701359327, 17701745.
12. Bolger C, Tufvesson E, Sue-Chu M, Devereux G, Ayres J, Bjermer L, Kippelen P. Hyperpnea-induced bronchoconstriction and urinary CC16 levels in athletes. Med Sci Sports Exerc 2011, 43:1207-1213. 10.1249/MSS.0b013e31820750d8, 21131866.
13. Romberg K, Bjermer L, Tufvesson E. Exercise but not mannitol provocation increases urinary Clara cell protein (CC16) in elite swimmers. Resp Med 2011, 105:31-36.
14. Carbonnelle S, Francaux M, Doyle I, Dumont X, de Burbure C, Morel G, Michel O, Bernard A. Changes in serum pneumoproteins caused by short-term exposures to nitrogen trichloride in indoor chlorinated swimming-pools. Biomarkers 2002, 7:464-478. 10.1080/13547500210166612, 12581482.
15. Benson M, Fransson M, Martinsson T, Naluai A, Uddman R, Cardell L. Inverse relation between nasal fluid Clara cell protein 16 levels and symptoms and signs of rhinitis in allergen-challenged patients with intermittent allergic rhinitis. Allergy 2007, 62:178-183.
16. Shijubo N, Itoh Y, Yamaguchi T, Sugaya F, Hirasawa M, Yamada T, Kawai T, Abe S. Serum levels of Clara cell 10-kDa protein are decreased in patients with asthma. Lung 1999, 177:45-52. 10.1007/PL00007626, 9835633.
17. Wang S, Rosenberger C, Bao Y, Stark J, Harrod K. Clara cell secretory protein modulates lung inflammatory and immune responses to respiratory syncytial virus infection. J Immunol 2003, 171:1051-1060. 10.4049/jimmunol.171.2.1051, 12847279.
18. GINA Report, Global Strategy for Asthma Management and Prevention 2011, Updated 2011. http://www.ginasthma.org/uploads/users/files/GINA_Report2011_May4.pdf [accessed 23 June 2012].
19. Bousquet J, Schünemann H, Samolinski B, Demoly P, Baena-Cagnani C, Bachert C, Bonini S, Boulet LP, Bousquet PJ, Brozek JL, Canonica GW, Casale TB, Cruz AA, Fokkens WJ, Fonseca JA, van Wijk RG, Grouse L, Haahtela T, Khaltaev N, Kuna P, Lockey RF, Lodrup Carlsen KC, Mullol J, Naclerio R, O'Hehir RE, Ohta K, Palkonen S, Papadopoulos NG, Passalacqua G, Pawankar R. Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs. J Allergy Clin Immunol 2012, 130:1049-1062. 10.1016/j.jaci.2012.07.053, 23040884.
20. Bonini M, Braido F, Baiardini I, Del Giacco S, Gramiccioni C, Manara M, Tagliapietra G, Scardigno A, Sargentini V, Brozzi M, Rasi G, Bonini S. AQUA: Allergy Questionnaire for Athletes. Development and validation. Med Sci Sports Exerc 2009, 41:1034-1041. 10.1249/MSS.0b013e318193c663, 19346984.
21. Miller M, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J, ATS/ERS Task Force Standardisation of spirometry. Eur Respir J 2005, 26:319-338. 10.1183/09031936.05.00034805, 16055882, ATS/ERS Task Force.
22. Bernard A, Carbonnelle S, Dumont X, Nickmilder M. Infant swimming practice, pulmonary epiuthelium integrity, and the risk of allergic and respiratory diseases later in childhood. Pediatrics 2007, 119:1095-1103. 10.1542/peds.2006-3333, 17545376.
23. Lagerkvist B, Bernard A, Blomberg A, Bergstrom E, Forsberg B, Holmstrom K, Karp K, Lundstrom NG, Segerstedt B, Svensson M, Nordberg G. Pulmonary epithelial integrity in children: relationship to ambient ozone exposure and swimming pool attendance. Environ Health Perspect 2004, 112:1768-1771. 10.1289/ehp.7027, 1253671, 15579425.
24. Carbonnelle S, Bernard A, Doyle I, Grutters J, Francaux M. Fractional exhaled NO and serum pneumoproteins after swimming in a chlorinated pool. Med Sci Sports Exerc 2008, 40:1472-1476. 10.1249/MSS.0b013e3181733159, 18614944.
25. Fernández-Luna T, Gallardo L, Plaza-Carmona M, García-Unanue J, Sánchez-Sánchez J, Felipe J, Burillo P, Ara I. Respiratory function and changes in lung epithelium biomarkers after a short-training intervention in chlorinated vs. ozone indoor pools. PLoS One 2013, 8:e68447. 10.1371/journal.pone.0068447, 3709909, 23874631.
26. Braido F, Riccio A, Guerra L, Gamalero C, Zolezzi A, Tarantini F, De Giovanni B, Folli C, Descalzi D, Canonica GW. Clara cell 16 protein in COPD sputum: a marker of small airways damage?. Resp Med 2007, 101:2119-2124.
27. Jacobs J, Fuertes E, Krop E, Spithoven J, Tromp P, Heederik D. Swimming pool attendance and respiratory symptoms and allergies among Dutch children. Occup Environ Med 2012, 69:823-830. 10.1136/oemed-2011-100621, 22864284.
28. Broeckaert F, Clippe A, Knoops B, Hermans C, Bernard A. Clara Cell Secretory Protein (CC16): features as a peripheral lung biomarker. Ann N Y Acad Sci 2000, 923:68-77.
29. Sengler C, Heinzmann A, Jerkic S, Haider A, Sommerfeld C, Niggemann B, Lau S, Forster J, Schuster A, Kamin W, Bauer C, Laing I, LeSouef P, Wahn U, Deichmann K, Nickel R. Clara cell protein 16 (CC16) gene polymorphism influences the degree of airway responsiveness in asthmatic children. J Allergy Clin Immunol 2003, 111:515-519. 10.1067/mai.2003.180, 12642831.