Hyperpnea-induced bronchoconstriction and urinary CC16 levels in athletes

Medicine and Science in Sports and Exercise

Volumn 43, Issue 7, 2011, Pages 1207-1213

  Bolger, Claire ^a   Tufvesson, Ellen ^b   Sue Chu, Malcolm ^c,d   Devereux, Graham ^a   Ayres, Jon G ^a,e   Bjermer, Leif ^b   Kippelen, Pascale ^a,f  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^d NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^e UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^f BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

ASTHMA; EPITHELIAL INJURY; EUCAPNIC VOLUNTARY HYPERPNEA; EXERCISE INDUCED BRONCHOCONSTRICTION; FEMALES

Indexed keywords

CLARA CELL SECRETORY PROTEIN; UTEROGLOBIN;

ADOLESCENT; ADULT; ARTICLE; ATHLETE; BRONCHOSPASM; EXERCISE INDUCED ASTHMA; EXERCISE TEST; FEMALE; HUMAN; HYPERVENTILATION; LUNG FUNCTION TEST; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; URINE;

ADOLESCENT; ADULT; ASTHMA, EXERCISE-INDUCED; ATHLETES; BRONCHOCONSTRICTION; EXERCISE TEST; FEMALE; HUMANS; HYPERVENTILATION; MIDDLE AGED; RESPIRATORY FUNCTION TESTS; UTEROGLOBIN; YOUNG ADULT;

EID: 79959860128     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e31820750d8     Document Type: Article

References (39)

1. Anderson SD, Holzer K. Exercise-induced asthma: is it the right diagnosis in elite athletes? J Allergy Clin Immunol. 2000;106(3): 419-28. (Pubitemid 32037692)
2. Anderson SD, Kippelen P. Airway injury as a mechanism for ex¬ercise-induced bronchoconstriction in elite athletes. J Allergy Clin Immunol. 2008;122(2):225-35.
3. Anderson SD, Kippelen P. Exercise-induced bronchoconstriction: pathogenesis. Curr Allergy Asthma Rep. 2005;5(2):116-22. (Pubitemid 40331067)
4. Andersson L, Lundberg PA, Barregard L. Methodological aspects on measurement of Clara cell protein in urine as a biomarker for airway toxicity, compared with serum levels. J Appl Toxicol. 2007; 27(1):60-6. (Pubitemid 46180787)
5. Arsalane K, Broeckaert F, Knoops B, Clippe A, Buchet JP, Bernard A. Increased serum and urinary concentrations of lung Clara cell protein in rats acutely exposed to ozone. Toxicol Appl Pharmacol. 1999;159(3):169-74. (Pubitemid 29451124)
6. Arsalane K, Broeckaert F, Knoops B, Wiedig M, Toubeau G, Bernard A. Clara cell specific protein (CC16) expression after acute lung inflammation induced by intratracheal lipopolysaccha-ride administration. Am J Respir Crit Care Med. 2000;161(5): 1624-30. (Pubitemid 30329039)
7. Bonsignore MR, Morici G, Riccobono L, et al. Airway inflam¬mation in nonasthmatic amateur runners. Am J Physiol Lung Cell Mol Physiol. 2001;281(3):668-76.
8. Bougault V, Turmel J, St-Laurent J, Bertrand M, Boulet LP. Asthma, airway inflammation and epithelial damage in swimmers and cold-air athletes. Eur Respir J. 2009;33(4):740-6.
9. Broeckaert F, Arsalane K, Hermans C, et al. Serum Clara cell protein: a sensitive biomarker of increased lung epithelium per¬meability caused by ambient ozone. Environ Health Perspect. 2000;108(6):533-7. (Pubitemid 30453775)
10. Cabral AL, Conceicao GM, Fonseca-Guedes CH, Martins MA. Exercise-induced bronchospasm in children: effects of asthma se¬verity. Am J Respir Crit Care Med. 1999;159(6):1819-23. (Pubitemid 29275049)
11. Carbonnelle S, Francaux M, Doyle I, et al. Changes in serum pneumoproteins caused by short-term exposures to nitrogen tri¬chloride in indoor chlorinated swimming pools. Biomarkers. 2002; 7(6):464-78. (Pubitemid 36113426)
12. Carlsen KH, Anderson SD, Bjermer L, et al. Exercise-induced asthma, respiratory and allergic disorders in elite athletes: epide¬miology, mechanisms and diagnosis: part I of the report from the Joint Task Force of the European Respiratory Society (ERS) and the European Academy of Allergy and Clinical Immunology (EAACI) in cooperation with GA2LEN. Allergy. 2008;63(4):387-403. (Pubitemid 351341832)
13. Chen LC, Zhang Z, Myers AC, Huang SK. Cutting edge: altered pulmonary eosinophilic inflammation in mice deficient for Clara cell secretory 10-kDa protein. J Immunol. 2001;167(6):3025-8. (Pubitemid 32852537)
14. Chimenti L, Morici G, Paterno A, et al. Endurance training dam¬ages small airway epithelium in mice. Am J Respir Crit Care Med. 2007;175(5):442-9. (Pubitemid 46354247)
15. Chimenti L, Morici G, Paterno A, et al. Bronchial epithelial dam¬age after a half-marathon race in non-asthmatic amateur runners. Am J Physiol Lung Cell Mol Physiol. 2010;298(6):L857-62.
16. Davis MS, Lockard AJ, Marlin DJ, Freed AN. Airway cooling and mucosal injury during cold weather exercise. Equine Vet J Suppl. 2002;(34):413-6.
17. 99Tc m] DTPA: effects of ventilation pattern. Clin Physiol. 1990; 10(2):189-99. (Pubitemid 20129170)
18. Freed AN, Davis MS. Hyperventilation with dry air increases air¬way surface fluid osmolality in canine peripheral airways. Am J Respir Crit Care Med. 1999;159(4):1101-7. (Pubitemid 29202542)
19. Global Initiative for Asthma (GINA) Web site [Internet]: Global Strategy for Asthma Management and Prevention; [cited Jun 14 2010]. Available from: http://www.ginasthma.org.
20. Hallstrand TS, Moody MW, Aitken ML, Henderson WR Jr. Air¬way immunopathology of asthma with exercise-induced broncho-constriction. J Allergy Clin Immunol. 2005;116(3):586-93. (Pubitemid 41267132)
21. Hallstrand T, Moody M, Wurfel M, Schwartz L, Henderson W, Aitken M. Inflammatory basis of exercise-induced bronchocon-striction. Am J Respir Crit Care Med. 2005;172:679-86.
22. Hermans C, Bernard A. Pneumoproteinaemia: a new perspective in the assessment of lung disorders. Eur Respir J. 1998;11(4):801-3. (Pubitemid 28231269)
23. 2 inhibitor, in acute lung injury. Eur Respir J. 1995;8(10):1647-53.
24. Kippelen P, Larsson J, Anderson SD, Brannan JD, Dahlén B, Dahlén SE. Effect of sodium cromoglycate on mast cell mediators during hyperpnea in athletes. Med Sci Sports Exerc. 2010;42(10): 1853-60.
25. Kippelen P, Larsson J, Anderson S, et al. Acute effects of beclo-methasone on hyperpnoea-induced bronchoconstriction. Med Sci Sports Exerc. 2010;42(2):273-80.
26. Lagerkvist BJ, Bernard A, Blomberg A, et al. Pulmonary epithe¬lial integrity in children: relationship to ambient ozone exposure and swimming pool attendance. Environ Health Perspect. 2004; 112(17):1768-71. (Pubitemid 40017300)
27. 2-mediated inhibition of fibroblast mi¬gration in vitro. Am J Respir Crit Care Med. 1995;152(1):290-7.
28. Mickleborough TD, Murray RL, Ionescu AA, Lindley MR. Fish oil supplementation reduces severity of exercise-induced bron-choconstriction in elite athletes. Am J Respir Crit Care Med. 2003; 168(10):1181-9. (Pubitemid 37421835)
29. Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J. 2005;26(2):319-38. (Pubitemid 41079078)
30. Nanson CJ, Burgess JL, Robin M, Bernard AM. Exercise alters serum pneumoprotein concentrations. Respir Physiol. 2001;127(2-3): 259-65. (Pubitemid 32720511)
31. Nilsson H, Dragomir A, Ahlander A, Johannesson M, Roomans GM. Effects of hyperosmotic stress on cultured airway epithelial cells. Cell Tissue Res. 2007;330(2):257-69. (Pubitemid 47512594)
32. Omori C, Schofield B, Mitzner W, Freed A. Hyperpnea with dry air causes time-dependent alterations in mucosal morphol¬ogy and bronchovascular permeability. J Appl Physiol. 1995; 78(3):1043-51.
33. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Lung volumes and forced ventilatory flows: report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl. 1993;16:5-40.
34. Reiss TF, Hill JB, Harman E, et al. Increased urinary excretion of LTE4 after exercise and attenuation of exercise-induced broncho-spasm by montelukast, a cysteinyl leukotriene receptor antagonist. Thorax. 1997;52(12):1030-5. (Pubitemid 27515780)
35. Romberg K, Bjermer L, Tufvesson E. Exercise but not mannitol provocation increases urinary Clara cell protein (CC16) in elite swimmers. Respir Med. 2011;105(1):31-6.
36. Singh G, Singh J, Katyal SL, et al. Identification, cellular locali¬zation, isolation, and characterization of human Clara cell-specific 10 kD protein. J Histochem Cytochem. 1988;36(1):73-80. (Pubitemid 18023406)
37. Stanford KI, Mickleborough TD, Ray S, Lindley MR, Koceja DM, Stager JM. Influence of menstrual cycle phase on pulmonary function in asthmatic athletes. Eur J Appl Physiol. 2006;96(6): 703-10.
38. 99mTc-DTPA clear¬ance in humans. Am J Respir Crit Care Med. 1995;152(1):108-12.
39. Timonen KL, Hoek G, Heinrich J, et al. Daily variation in fine and ultrafine particulate air pollution and urinary concentrations of lung Clara cell protein CC16. Occup Environ Med. 2004;61: 908-14 (Pubitemid 39389351)