Polycythaemia-inducing mutations in the erythropoietin receptor (EPOR): Mechanism and function as elucidated by epidermal growth factor receptor-EPOR chimeras

British Journal of Haematology

Volumn 165, Issue 4, 2014, Pages 519-528

  Gross, Mor ^a   Ben Califa, Nathalie ^a   Mcmullin, Mary F ^b   Percy, Melanie J ^b   Bento, Celeste ^c   Cario, Holger ^d   Minkov, Milen ^e   Neumann, Drorit ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^d UNIVERSITY HOSPITAL ULM   (Germany)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Chimeric receptors; Erythrocytosis; Erythropoietin receptor; Myeloproliferative disorder

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ERYTHROPOIETIN RECEPTOR; GLYCAN;

ARTICLE; CELL MATURATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME MECHANISM; ERYTHROCYTE; GENE DELETION; HEREDITARY SPHEROCYTOSIS; HUMAN; HUMAN CELL; MISSENSE MUTATION; NONSENSE MUTATION; POLYCYTHEMIA; PRIMARY FAMILIAL AND CONGENITAL POLYCYTHAEMIA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

CHIMERIC RECEPTORS; ERYTHROCYTOSIS; ERYTHROPOIETIN RECEPTOR; MYELOPROLIFERATIVE DISORDER;

CELL LINE; CELL MEMBRANE; CODON, NONSENSE; DNA MUTATIONAL ANALYSIS; GLYCOSYLATION; HUMANS; JANUS KINASE 2; MAP KINASE SIGNALING SYSTEM; MUTATION, MISSENSE; POLYCYTHEMIA; POLYSACCHARIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ERYTHROPOIETIN; RECOMBINANT FUSION PROTEINS; SEQUENCE DELETION; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 84899486717     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12782     Document Type: Article

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