Measuring the effect of avermectins and milbemycins on somatic muscle contraction of adult Haemonchus contortus and on motility of Ostertagia circumcincta in vitro

Parasitology

Volumn 141, Issue 7, 2014, Pages 948-956

  Demeler, Janina ^a,b   Von Samson Himmelstjerna, Georg ^a   Sangster, Nicholas C ^b,c  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF SYDNEY   (Australia)

^c CHARLES STURT UNIVERSITY   (Australia)

Author keywords

anthelmintic resistance; contraction; in vitro assays; motility; muscle transducer; sheep nematodes

Indexed keywords

AVERMECTIN; IVERMECTIN; MILBEMYCIN; MOXIDECTIN; IVERMECTIN B1A; IVERMECTIN B1B; MILBEMYCIN A3; MILBEMYCIN A4; UNCLASSIFIED DRUG; ANTIPARASITIC AGENT; MACROLIDE;

ANALYTICAL EQUIPMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HAEMONCHUS CONTORTUS; IN VITRO STUDY; MICROMOTILITY METER; MONILIFORMIS; MUSCLE CONTRACTION; NONHUMAN; OSTERTAGIA CIRCUMCINCTA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; ADULT; ANTHELMINTIC ACTIVITY; DRUG POTENCY; TRANSDUCER; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; HAEMONCHUS; MUSCLE; OSTERTAGIA;

HAEMONCHUS CONTORTUS; NEMATODA; OVIS ARIES; TELADORSAGIA CIRCUMCINCTA;

ANIMALS; ANTIPARASITIC AGENTS; FEMALE; HAEMONCHUS; IVERMECTIN; MACROLIDES; MUSCLE CONTRACTION; MUSCLES; OSTERTAGIA;

EID: 84899483506     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S0031182013002291     Document Type: Article

References (32)

1. Anziani, O. S., Suarez, V. H., Guglielmone, A. A., Warnke, O., Grande, H. and Coles, G. C. (2004). Resistance to benzimidazole and macrocyclic lactone anthelmintics in cattle nematodes in Argentina. Veterinary Parasitology 122, 303-306.
2. Bennet, J. L. and Pax, R. A. (1987). Micromotility Meter: an instrumentation to analyse helminth motility. Parasitology Today 3, 159-160.
3. Conder, G. A., Thompson, D. P. and Johnson, S. S. (1993). Demonstration of co-resistance of Haemonchus contortus to ivermectin and moxidectin. Veterinary Record 132, 651-652.
4. Demeler, J., Van Zeveren, A. M., Kleinschmidt, N., Vercruysse, J., Hoglund, J., Koopmann, R., Cabaret, J., Claerebout, E., Areskog, M. and von Samson-Himmelstjerna, G. (2009). Monitoring the efficacy of ivermectin and albendazole against gastro intestinal nematodes of cattle in Northern Europe. Veterinary Parasitology 160, 109-115.
5. Demeler, J., Gill, J. H., von Samson-Himmelstjerna, G. and Sangster, N. C. (2013). The in vitro assay profile of macrocyclic lactone resistance in three species of sheep trichostrongyloids. International Journal for Parasitology-Drugs and Drug Resistance 3, 109-118.
6. Folz, S. D., Pax, R. A., Thomas, E. M., Bennett, J. L., Lee, B. L. and Conder, G. A. (1987a). Detecting in vitro anthelmintic effects with a micromotility meter. Veterinary Parasitology 24, 241-250.
7. Folz, S. D., Pax, R. A., Thomas, E. M., Bennett, J. L., Lee, B. L. and Conder, G. A. (1987b). Development and validation of an in vitro Trichostrongylus colubriformis motility assay. International Journal for Parasitology 17, 1441-1444.
8. Geary, T. G., Sims, S. M., Thomas, E. M., Vanover, L., Davis, J. P., Winterrowd, C. A., Klein, R. D., Ho, N. F. H. and Thompson, D. P. (1993). Haemonchus contortus: ivermectin-induced paralysis of the pharynx. Experimental Parasitology 77, 88-96.
9. Gill, J. H. and Lacey, E. (1998). Avermectin/milbemycin resistance in trichostrongyloid nematodes. International Journal for Parasitology 28, 863-877.
10. Gill, J. H., Redwin, J. M., Van Wyk, J. A. and Lacey, E. (1995). Avermectin inhibition of larval development in Haemonchus contortus-effects of ivermectin resistance. International Journal for Parasitology 25, 463-470.
11. Jackson, R., Rhodes, A. P., Pomroy, W. E., Leathwick, D. M., West, D. M., Waghorn, T. S. and Moffat, J. R. (2006). Anthelmintic resistance and management of nematode parasites on beef cattle-rearing farms in the North Island of New Zealand. New Zealand Veterinary Journal 54, 289-296.
12. Kass, I. S., Stretton, A. O.W. and Wang, C. C. (1984). The effects of avermectin and drugs related to acetylcholine and 4-aminobutyric acid on neurotransmission in Ascaris suum. Molecular and Biochemical Parasitology 13, 213-225.
13. Kohler, P. (2001). The biochemical basis of anthelmintic action and resistance. International Journal for Parasitology 31, 336-345.
14. Kotze, A. C., Hines, B. M. and Ruffell, A. P. (2012). A reappraisal of the relative sensitivity of nematode pharyngeal and somatic musculature to macrocyclic lactone drugs. International Journal for Parasitology: Drugs and Drug Resistance 2, 29-35.
15. Le Jambre, L., Geoghegan, J. and Lyndal-Murphy, M. (2005). Characterization of moxidectin resistant Trichostrongylus colubriformis and Haemonchus contortus. Veterinary Parasitology 128, 83-90.
16. Marks, N. J., Sangster, N. C., Maule, A. G., Halton, D.W., Thompson, D. P., Geary, T. G. and Shaw, C. (1999). Structural characterisation and pharmacology of KHEYLRamide (AF2) and KSAYMRFamide (PF3/AF8) from Haemonchus contortus. Molecular and Biochemical Parasitology 100, 185-194.
17. McCavera, S., Walsh, T. K. and Wolstenholme, A. J. (2007). Nematode ligand-gated chloride channels: an appraisal of their involvement in macrocyclic lactone resistance and prospects for developing molecular markers. Parasitology 134, 1111-1121.
18. Mejía, M. E., Fernandez Igartúa, B. M., Schmidt, E. E. and Cabaret, J. (2003). Multispecies and multiple anthelmintic resistance on cattle nematodes in a farm in Argentina: the beginning of high resistance. Veterinary Research 34, 461-467.
19. Moreno, Y., Nabhan, J. F., Solomon, J., Mackenzie, C. D. and Geary, T. G. (2010). Ivermectin disrupts the function of the excretorysecretory apparatus in microfilariae of Brugia malayi. Proceedings of the National Academy of Sciences USA 107, 20120-20125.
20. Portillo, V., Jagannathan, S. and Wolstenholme, A. J. (2003). Distribution of glutamate-gated chloride channel subunits in the parasitic nematode Haemonchus contortus. Journal of Comparative Neurology 462, 213-222.
21. Richards, J. C., Behnke, J. M. and Duce, I. R. (1995). In vitro studies on the relative sensitivity to ivermectin of Necator americanus and Ancylostoma ceylanicum. International Journal for Parasitology 25, 1185-1191.
22. Sangster, N. C. and Bjorn, H. (1995). Levamisole resistance in Haemonchus contortus selected at different stages of infection. International Journal for Parasitology 25, 343-348.
23. Sangster, N. C., Davis, C.W. and Collins, G. H. (1991). Effects of cholinergic drugs on longitudinal contraction in levamisole-susceptible andresistant Haemonchus contortus. International Journal for Parasitology 21, 689-695.
24. Sangster, N. C., Song, J. and Demeler, J. (2005). Resistance as a tool for discovering and understanding targets in parasite neuromusculature. Parasitology 131 (Suppl.), S179-190.
25. Sheriff, J. C., Kotze, A. C., Sangster, N. C. and Martin, R. J. (2002). Effects of macrocyclic lactone anthelmintics on feeding and pharyngeal pumping in Trichostrongylus colubriformis in vitro. Parasitology 125, 477-484.
26. Sheriff, J. C., Kotze, A. C., Sangster, N. C. and Hennessy, D. R. (2005). Effect of ivermectin on feeding by Haemonchus contortus in vivo. Veterinary Parasitology 128, 341-346.
27. Shoop,W. L. (1993). Ivermectin resistance. Parasitology Today 9, 154-159.
28. Soutello, R. V. G., Seno, M. C. Z. and Amarante, A. F. T. (2007). Anthelmintic resistance in cattle nematodes in northwestern São Paulo State, Brazil. Veterinary Parasitology 148, 360-364.
29. Suarez, V. H. and Cristel, S. L. (2007). Anthelmintic resistance in cattle nematode in the western Pampeana Region of Argentina. Veterinary Parasitology 144, 111-117.
30. Sutherland, I. A., Leathwick, D. M., Moen, I. C. and Bisset, S. A. (2002). Resistance to therapeutic treatment with macrocyclic lactones anthelmintic in Ostertagia circumscripta. Veterinary Parasitology 109, 91-99.
31. Waghorn, T. S., Leathwick, D. M., Rhodes, A. P., Jackson, R., Pomroy, W. E., West, D. M. and Moffat, J. R. (2006). Prevalence of anthelmintic resistance in 62 beef cattle farms in the North Island of New Zealand. New Zealand Veterinary Journal 54, 278-282.
32. Wolstenholme, A. J. and Rogers, A. T. (2005). Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. Parasitology 131 (Suppl.), S85-S95.