Cytomegalovirus viral load kinetics in patients with HIV/AIDS admitted to a medical intensive care unit: A case for pre-emptive therapy

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Mayaphi, Simnikiwe H ^a   Brauer, Marieke ^a   Morobadi, Daniel M ^a   Mazanderani, Ahmad H ^a   Mafuyeka, Rendani T ^a   Olorunju, Steve A S ^b   Tintinger, Gregory R ^a   Stoltz, Anton ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; ANTIVIRUS AGENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; FEMALE; FOLLOW UP; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MICROBIAL KINETICS; MORTALITY; NONHUMAN; RETROSPECTIVE STUDY; SEROLOGY; TREATMENT OUTCOME; VIRUS DETECTION; VIRUS LOAD KINETICS; CYTOMEGALOVIRUS INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; ISOLATION AND PURIFICATION; MIDDLE AGED; VIROLOGY; VIRUS LOAD;

ADULT; ANTIVIRAL AGENTS; CD4 LYMPHOCYTE COUNT; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; GANCICLOVIR; HIV INFECTIONS; HUMANS; INTENSIVE CARE UNITS; MIDDLE AGED; VIRAL LOAD;

EID: 84899450656     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0093702     Document Type: Article

References (30)

1. Atkinson C, Emery VC (2011) Cytomegalovirus quantification: Where to next in optimising patient management? J Clin Virol 51: 223-8.
2. Sundar IK (2004) Update: cytomegalovirus infection in HIV-infected patients - a review. Clin Microbiol Newsl 26: 137-44.
3. Mocarski Jr ES, Shenk T, Pass RF (2007) Cytomegaloviruses. In: Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, et al, editors. Fields Virology. 5th ed. Philadelphia: Lippincot Williams & Wilkins, a Wolters Kluwer business. pp. 2701-72.
4. Barron MA, Weinberg A (2005) Common viral infections in transplant recipients, part 1. Herpesviruses. Clin Microbiol Newsl 27: 99-106. (Pubitemid 40835895)
5. De la Hoz RE, Stephens G, Sherlock C (2002) Diagnosis and treatment approaches of CMV infections in adult patients. J Clin Virol 25: 1-12.
6. Li H, Dummer JS, Estes WR, Meng S, Wright PF, et al. (2003) Measurement of Human Cytomegalovirus Loads by Quantitative Real-Time PCR for Monitoring Clinical Intervention in Tranplant Recipients. J Clin Microbiol 41: 187-91. (Pubitemid 36098574)
7. Halfon P, Berger P, Khiri H, Martineau A, Pénaranda G, et al. (2011) Algorithm based on CMV kinetics DNA viral load for preemptive therapy initiation after hematopoietic cell transplantation. J Med Virol 83: 490-5.
8. Martín-Gandul C, Pérez-Romero P, Sánchez M, Bernal G, Suárez G, et al. (2013) Determination, validation and standardization of a CMV DNA cut-off value in plasma for preemptive treatment of CMV infection in solid organ transplant recipients at lower risk for CMV infection. J Clin Virol 56: 13-18.
9. Robberts FJL, Liebowitz LD, Chalkley LJ (2007) Polymerase chain reaction detection of Pneumocystis jiroveci: evaluation of 9 assays. Diagn Microbiol Infect Dis 58: 385-92. (Pubitemid 47198402)
10. Ayoub T, Chow J (2008) The conventional autopsy in modern medicine. J R Soc Med 101: 177-181. (Pubitemid 351668975)
11. Bloch EM, Vermeulen M, Murphy E (2012) Blood Transfusion Safety in Africa: A Literature Review of Infectious Disease and Organizational Challenges. Transfus Med Rev 26: 164-80.
12. Preiser W, Bräuninger S, Schwerdtfeger R, Ayliffe U, Garson JA, et al. (2001) Evaluation of diagnostic methods for the detection of cytomegalovirus in recipients of allogeneic stem cell transplants. J Clin Virol 20: 59-70. (Pubitemid 32037152)
13. De Keyzer K, Van Laecke S, Peeters P, Vanholder R (2011) Human Cytomegalovirus and Kidney Transplantation: A Clinician's Update. Am J Kidney Dis 58: 118-26.
14. Griffiths PD (2012) Burden of disease associated with human cytomegalovirus and prospects for elimination by universal immunisation. Lancet Infect Dis 12:790-8.
15. Levitsky J, Freifeld AG, Puumala S, Bargenquast K, Hardiman P, et al. (2008) Cytomegalovirus viremia in solid organ transplantation: does the initial viral load correlate with risk factors and outcomes? Clin Transplant 22: 222-8. (Pubitemid 351420017)
16. Fielding K, Koba A, Grant AD, Charalambous S, Day J, et al. (2011) Cytomegalovirus Viremia as a Risk Factor for Mortality Prior to Antiretroviral Therapy among HIV-Infected Gold Miners in South Africa. PLoS One 6: e25571.
17. Boffi El Amari E, Combescure C, Yerly S, Calmy A, Kaiser L, et al. (2011) Clinical relevance of cytomegalovirus viraemia. HIV Med 12: 394-402.
18. Durier N, Ananworanich J, Apornpong T, Ubolyam S, Kerr SJ, et al. (2013) Cytomegalovirus Viremia in Thai HIV-Infected Patients on Antiretroviral Therapy: Prevalence and Associated Mortality. CID 57: 147-55.
19. Mizushima D, Nishijima T, Gatanaga H, Tsukada K, Teruya K, et al. (2013) Preemptive Therapy Prevents Cytomegalovirus End-Organ Disease in Treatment-Naive Patients with Advanced HIV-1 Infection in the HAART Era. PLoS One 8: e65348.
20. Spector SA, McKinley GF, Lalezari JP, Samo T, Andruczk R, et al. (1996) Oral Ganciclovir for the Prevention of Cytomegalovirus Disease in Persons with AIDS. N Engl J Med 334: 1491-7. (Pubitemid 26166891)
21. Ruell J, Barnes C, Mutton K, Foulkes B, Chang J, et al. (2007) Active CMV disease does not always correlate with viral load detection. Bone Marrow Transpl 40: 55-61. (Pubitemid 47018414)
22. Rasmussen L, Zipeto D, Wolitz RA, Dowling A, Efron B, et al. (1997) Risk for Retinitis in Patients with AIDS Can Be Assessed by Quantitation of Threshold Levels of Cytomegalovirus DNA Burden in Blood. JID 176: 1146-55. (Pubitemid 27460977)
23. Metras D, Viard L, Kreitmann B, Riberi A, Pannetier-Mille A, et al. (1999) Lung infections in pediatric lung transplantation: experience in 49 cases. Eur J Cardio-Thorac 15: 490-5. (Pubitemid 29210354)
24. Eid AJ, Arthurs SK, Deziel PJ, Wilhelm MP, Razonable RR (2010) Clinical Predictors of Relapse after Treatment of Primary Gastrointestinal Cytomegalovirus Disease in Solid Organ Transplant Recipients. Am J Transplant 10: 157-61.
25. Chemaly RF, Yen-Lieberman B, Castilla EA, Reilly A, Arrigain S, et al. (2004) Correlation between Viral Loads of Cytomegalovirus in Blood and Bronchoalveolar Lavage Specimens from Lung Transplant Recipients Determined by Histology and Immunohistochemistry. J Clin Microbiol 42: 2168-72. (Pubitemid 38637838)
26. Ganzenmueller T, Henke-Gendo C, Schlué J, Wedemeyer J, Huebner S, et al. (2009) Quantification of cytomegalovirus DNA levels in intestinal biopsies as a diagnostic tool for CMV intestinal disease. J Clin Virol 46: 254-8.
27. Henke-Gendo C, Ganzenmueller T, Kluba J, Harste G, Raggub L, et al. (2012) Improved Quantitative PCR Protocols for Adenovirus and CMV With an Internal Inhibition Control System and Automated Nucleic Acid Isolation. J Med Virol 84: 890-6.
28. Gallant JE, Moore RD, Richman DD, Keruly J, Chaisson RE, et al. (1992) Incidence and Natural History of Cytomegalovirus Disease in Patients with Advanced Human Immunodeficiency Virus Disease Treated with Zidovudine. JID 166; 1223-7.
29. Spector AS, Wong R, Hsia K, Pilcher M, Stempien MJ (1998) Plasma Cytomegalovirus (CMV) DNA Load Predicts CMV Disease and Survival in AIDS Patients. J Clin Invest 101: 497-502. (Pubitemid 28067348)
30. Laher F, Cullen C, Matlala JB (2012) Localised treatment and 6-month outcomes in patients with cytomegalovirus retinitis at a tertiary ophthalmology service in Ga-Rankuwa. S Afr J HIV Med 13: 68-71.